Sequences from the Low Density Lipoprotein Receptor-related Protein (LRP) Cytoplasmic Domain Enhance Amyloid β Protein Production via the β-Secretase Pathway without Altering Amyloid Precursor Protein/LRP Nuclear Signaling [PDF]
, 2005 Il‐Sang Yoon +3 more
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Impacts of membrane biophysics in Alzheimer’s disease: from amyloid precursor protein processing to Aβ peptide-induced membrane changes [PDF]
, 2011 An increasing amount of evidence supports the notion that cytotoxic effects of amyloid-β peptide (Aβ), the main constituent of senile plaques in Alzheimer’s disease (AD), are strongly associated with its ability to interact with membranes of neurons and
Askarova, Sholpan +2 more
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The Role of Presenilin-1 in the γ-Secretase Cleavage of the Amyloid Precursor Protein of Alzheimer's Disease [PDF]
, 2000 Jean‐Noël Octave +5 more
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Activity of α‐Secretase as the Common Final Effector of Protein Kinase C‐Dependent and ‐Independent Modulation of Amyloid Precursor Protein Metabolism [PDF]
, 1999 Marco Racchi +3 more
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Is anti-cholinesterase therapy of Alzheimer's disease delaying progression? [PDF]
, 2018 During the last decade, a systematic effort to develop a pharmacological treatment for Alzheimer's disease (AD) resulted in three drugs being registered for the first time in the US and Europe.
Giacobini, E.
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The Role of BIN1 in Alzheimer’s Disease [PDF]
, 2015 阿尔茨海默症（Alzheimer’sdisease,AD）是与年龄相关的神经退行性疾病，其主要的病理学特征为由β-淀粉样蛋白(-amyloid,Aβ)聚集产生的老年斑（senileplaues,SP）以及由异常磷酸化的tau蛋白组成的神经纤维缠结（neurofibrillarytangles,NFTs）。Aβ是由淀粉样前体蛋白（-amyloidprecursorprotein,APP）经过β-分泌酶和γ-分泌酶的依次顺序剪切而产生 ...
牛萌萌
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Presenilin‐dependent γ‐secretase processing of β‐amyloid precursor protein at a site corresponding to the S3 cleavage of Notch [PDF]
, 2001 Magdalena Sastre +7 more
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Evidence of endothelial dysfunction in the development of Alzheimer's disease : Is Alzheimer's a vascular disorder? [PDF]
, 2013 Acknowledgements Dr Soiza is funded by an NRS Career Research Fellowship.
Kelleher, Rory J., Soiza, Roy L
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β Subunits of Voltage-gated Sodium Channels Are Novel Substrates of β-Site Amyloid Precursor Protein-cleaving Enzyme (BACE1) and γ-Secretase [PDF]
, 2005 Hon Kit Wong +9 more
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The adipocyte differentiation protein APMAP is an endogenous suppressor of Aβ production in the brain [PDF]
, 2017 The deposition of amyloid-beta (Aβ) aggregates in the brain is a major pathological hallmark of Alzheimer's disease (AD). Aβ is generated from the cleavage of C-terminal fragments of the amyloid precursor protein (APP-CTFs) by γ-secretase, an ...
Alattia, Jean-René +6 more
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