Results 241 to 250 of about 14,023 (271)

Using an Amyloid Precursor Protein (APP) Reporter to Characterize α-Secretase

2003
Human genetic studies suggest decreasing amyloid peptide (Aβ) levels in the brain could alter the course of Alzheimer's disease (AD) (1 -4). Proteolytic cleavages govern the level of Aβ generated from the amyloid precursor protein (APP). β- and γ-cleavages at the amino and carboxyl termini of Aβ produce amyloidogenic peptides; in contrast, α-cleavage ...
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Blood brain barrier endothelial cells express candidate amyloid precursor protein-cleaving secretases

Amyloid, 1998
Proteolytic cleavage of the amyloid precursor protein (A beta PP) results in the generation of the amyloidogenic fragment known as amyloid beta peptide (A beta). Deposition of A beta in the brain parenchyma and cerebrovasculature is a feature of Alzheimer's disease (AD). To date, the process whereby A beta is generated and deposited remains unclear. We
E R, Simons, D C, Marshall, H J, Long, K, Otto, A, Billingslea, H, Tibbles, J, Wells, P, Eisenhauer, R E, Fine, D H, Cribbs, T A, Davies, C R, Abraham   +11 more
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Angiotensin-converting enzyme and the amyloid precursor protein secretases

Biochemical Society Transactions, 1999
N M, Hooper, S, Parvathy, E H, Karran, A J, Turner   +3 more
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Molecular characterisation of the alzheimer's amyloid precursor protein secretases

Biochemical Society Transactions, 1998
S L, Houldsworth, A J, Trew, N M, Hooper, A J, Turner   +3 more
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Specificity of the Alzheimer's amyloid precursor protein α-secretase

Trends in Biochemical Sciences, 1995
N M, Hooper, A J, Turner
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The contemporary management of cancers of the sinonasal tract in adults

Ca-A Cancer Journal for Clinicians, 2023
Rajat Thawani
exaly  

Highly accurate protein structure prediction with AlphaFold

Nature, 2021
John M Jumper, Richard Evans, Alexander Pritzel   +2 more
exaly  

Amyloid Oligomers: A Joint Experimental/Computational Perspective on Alzheimer’s Disease, Parkinson’s Disease, Type II Diabetes, and Amyotrophic Lateral Sclerosis

Chemical Reviews, 2021
Phuong H Nguyen, Ayyalusamy Ramamoorthy, Bikash Sahoo   +2 more
exaly  

Accurate prediction of protein structures and interactions using a three-track neural network

Science, 2021
Minkyung Baek, Frank DiMaio, Ivan Anishchenko   +2 more
exaly  

γ-Secretase; amyloid-β precursor protein (APP)

Science-Business eXchange, 2009
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