Results 161 to 170 of about 125,062 (284)
Zolpidem restores sleep and decreases amyloid in a mouse model
Alzheimer's &Dementia, Volume 22, Issue 3, March 2026.Abstract INTRODUCTION
Deficits in non–rapid eye movement (NREM) sleep facilitate Alzheimer's disease (AD) progression. Enhancing gamma‐aminobutyric acid‐ergic (GABAergic) signaling can restore sleep. Unbiased computational analysis identified zolpidem as high‐affinity GABA receptor modulator facilitating chloride transport that could slow AD.Lu Yu, Shinya Yokomizo, Tri H. Doan, Qiuchen Zhao, Akshatha Ganne, Meenakshisundaram Balasubramaniam, Ksenia V. Kastanenka +6 morewiley +1 more sourceTau PET overlap index correlation with neuropathological findings
Alzheimer's &Dementia, Volume 22, Issue 3, March 2026.Abstract INTRODUCTION
The tau positron emission tomography (PET) overlap index (OI) has shown promise in maximizing signal‐to‐noise for longitudinal tau PET imaging, particularly for early tau pathology, but requires validation against neuropathology.Seokbeen Lim, Jeyeon Lee, Paul H. Min, Christina M. Moloney, Carly T. Mester, Sujala Ghatamaneni, Matthew L. Senjem, Hugo Botha, David S. Knopman, Stuart J. McCarter, Vijay K. Ramanan, Rodolfo Savica, Julie A. Fields, Mary M. Machulda, Dennis W. Dickson, R. Ross Reichard, Aivi T. Nguyen, Jonathan Graff‐Radford, Christopher G. Schwarz, Jeffrey L. Gunter, Kejal Kantarci, Bradley Boeve, Prashanthi Vemuri, David T. Jones, Clifford R. Jack Jr., Ronald C. Petersen, Melissa E. Murray, Val J. Lowe +27 morewiley +1 more sourceObstructive sleep apnea severity, Alzheimer's disease plasma markers, and CSF brain amyloidosis and tau pathology
Alzheimer's &Dementia, Volume 22, Issue 3, March 2026.Abstract INTRODUCTION
We examined obstructive sleep apnea (OSA) severity's association with Alzheimer's disease (AD) plasma biomarkers, independent or synergistic with cerebrospinal fluid (CSF) amyloid, and as a proof of concept, whether plasma amyloid beta (Aβ)42/Aβ40 with OSA severity improves detection of amyloidosis and tau pathology.Omonigho Michael Bubu, Anna E. Mullins, Shreshtha Shah, Joshua L. Gills, Korey Kam, Ankit Parekh, Ogie Q. Umasabor‐Bubu, Arlener D. Turner, Mark Bernard, Anthony Briggs, Jaime Ramos‐Cejudo, Elena Valkanova, Alfred K. Mbah, Purbanka Pahari, Ludovic Debure, Mobeena Ghuman, Allal Boutajangout, Natasha J. Williams, Jeongyeon Hwang, Masrai K. Williams, David M. Rapoport, Indu Ayappa, Mony de Léon, Girardin Jean‐Louis, Andrew W. Varga, Ricardo S. Osorio +25 morewiley +1 more sourceGenetic correlation analysis identifies TMEM106B, ACE, and ERC2 as genetic loci shared between Alzheimer's disease and primary psychiatric disorders
Alzheimer's &Dementia, Volume 22, Issue 3, March 2026.Abstract INTRODUCTION
Neuropsychiatric symptoms (NPSs) occur in up to 85% of Alzheimer's disease (AD) cases. Current treatments – repurposed from psychiatric disorders despite limited understanding of etiologic overlap – are often ineffective. METHODS
To characterize the genetic overlap between AD and major psychiatric disorders and identify shared ...Ajneesh Kumar, Nicholas R. Ray, Jiji T. Kurup, Pamela Del Rosario, Masood Manoochehri, Colin Stein, Alyssa N. De Vito, Brenna Cholerton, Robert A. Sweet, Phil L. de Jager, Hans‐Ulrich Klein, Michael L. Cuccaro, Gary W. Beecham, Edward D. Huey, Christiane Reitz +14 morewiley +1 more sourceSex differences in neuromodulatory subcortical systems and their implications for Alzheimer's disease
Alzheimer's &Dementia, Volume 22, Issue 3, March 2026.Abstract
Neuromodulatory subcortical systems (NSSs) are uniquely susceptible to dementia‐related pathology, leading to frequent molecular and behavioral impairments associated with altered function of these nuclei. Some of these systems display clear sex‐specific cytoarchitecture and signaling leading to distinct physiology and behavioral outputs in ...Rosaria J. Rae, Jessica Marie Hunter Alberhasky, Marion Baillet, Debra A. Bangasser, Michael E. Belloy, Anne S. Berry, Chiara Berteotti, Hannah Bow, Rachel Buckley, Jessica Z. K. Caldwell, Matteo Carpi, Benjamin J. Clark, Claire J. Ciampa, Alexander C. Conley, Martin J. Dahl, Zoe R. Donaldson, Alexander J. Ehrenberg, Gillian Einstein, Neus Falgàs, Haley A. Fenlon, Megan C. Fitzhugh, Robert C. Froemke, Clara Gallay, Lea Tenenholz Grinberg, Derek A. Hamilton, Zia Hasan, Oihane Uriarte Huarte, Shaista Jabeen, Heidi I. L. Jacobs, Louis John Kolling, Elouise A. Koops, Sabrina Lenzoni, Claudio Liguori, Riccardo Manca, Catherine A. Marcinkiewcz, Tamunotonye Omoluabi, Rademene Oria, Caitlin A. Orsini, Nancy Elizabeth Ortega, Judy Pa, Nathan S. Pentkowski, Joana B. Pereira, Rhudovic Ramos, Derya Sargin, Abhijit Satpati, Maria Clara Selles, Mabel Seto, Shabana M. Shaik, Shireen Sindi, Gowoon Son, Valentine Ucheagwu, Maxime Van Egroo, Qi Yuan, Michael A. Kelberman +53 morewiley +1 more sourceCurrent Standards and Perspectives in Proteomics for Cardiac Amyloidosis. [PDF]
Anal ChemGreco F, McPhail E, Canetti D, Masri A, Ferrari Chen YF, Menichetti L, Aimo A, Franzini M, Ciccone L, Pucci A, Castiglione V, Limongelli G, Merlo M, Sinagra G, Basso C, Fontana M, Gillmore JD, McDonnell LA, Emdin M, Merlini G, Vergaro G. +20 moreeuropepmc +1 more source