Results 161 to 170 of about 99,289 (260)

Cardinal lessons in cardiac amyloidosis: diagnostic pitfalls across three cases-a case report. [PDF]

Eur Heart J Case Rep
Saleh G, Abou Ezzeddine O, Adel F.
europepmc   +1 more source

Molecular Mobility of N‐Acetylgalactosamine‐Modified Cyclodextrins on a Polyrotaxane for Highly Efficient Liver Targeting of Antibody Chimeras and Genome‐Editing Ribonucleoproteins

Advanced Science, Volume 13, Issue 49, 3 September 2026.
Monovalent N‐acetylgalactosamine (GalNAc)‐modified polyrotaxane enables efficient liver targeting by utilizing ligand mobility. The sliding and rotating cyclic components i.e., cyclodextrin in the polyrotaxane dynamically cluster GalNAc moieties, thereby mimicking trivalent interactions with asialoglycoprotein receptors.
Toru Taharabaru, Keiichi Motoyama, Yuting Wen, Zhongxing Zhang, Xuehao Tian, Jun Li, Taishi Higashi   +6 more
wiley   +1 more source

Amyloidosis & Advanced Heart Failure: When to Consider Cardiac Transplantation and What are the Results? [PDF]

Curr Heart Fail Rep
Hamilton S, Patolia H, Hanna M.
europepmc   +1 more source

Left Atrioventricular Coupling for Predicting Incident Atrial Fibrillation in Cardiac Amyloidosis

openABSTRACT BACKGROUND: Amyloidosis is a heterogeneous group of infiltrative diseases characterized by protein misfolding and extracellular deposition of insoluble amyloid fibrils. When the heart is involved, cardiac amyloidosis (CA) occurs.
LASTEI, SOFIA
core  

Clinical and Laboratory Characterization of Acquired Von Willebrand Syndrome

American Journal of Hematology, Volume 101, Issue 9, Page 2147-2156, September 2026.
ABSTRACT Acquired von Willebrand Syndrome (AVWS) is a rare bleeding disorder characterized by quantitative or qualitative defects of von Willebrand factor (VWF) in patients without a personal or family history of bleeding. It is frequently associated with systemic diseases, particularly lymphoproliferative disorders (LPDs) and myeloproliferative ...
Alessandro Ciavarella, Luciano Baronciani, Omid Seidizadeh, Paola Colpani, Elio Ingenito, Daniele Cattaneo, Maria Teresa Pagliari, Addolorata Truma, Alessandra Iurlo, Simona Maria Siboni, Flora Peyvandi   +10 more
wiley   +1 more source

Daratumumab monotherapy for relapsed AL amyloidosis: a single center retrospective analysis. [PDF]

Blood Res
Yi JH, Yoon SE, Kim SJ, Kim D, Choi JO, Min JH, Kim BJ, Kim JS, Lee JE, Jeon J, Choi JY, Kim K.   +11 more
europepmc   +1 more source

Cross‐tissue immune profiling of APOE ε4 reveals early dysregulation in Alzheimer's disease

Alzheimer's &Dementia, Volume 22, Issue 9, September 2026.
Abstract INTRODUCTION Apolipoprotein E (APOE) ε4 is the strongest genetic risk factor for late‐onset Alzheimer's disease (AD), but its contribution to disease pathogenesis remains incompletely understood. METHODS Here, we integrate proteomic profiling of plasma (n = 9028), cerebrospinal fluid (n = 1099), dorsolateral prefrontal cortex (n = 720), and ...
Artur Shvetcov, Shannon Thomson, Mark E. Graham, Brittany Hauger, Jessica E. Keller, Christine J. Smoyer, Sarah E. Tague, Ann‐Na Cho, Farhad B. Imam, Varsha Krish, Global Neurodegeneration Proteomics Consortium (GNPC), Matthew K. Taylor, Jonathan D. Mahnken, Debra K. Sullivan, Joanne H. Reed, Jeffrey M. Burns, Chad Slawson, Russell H. Swerdlow, Heather M. Wilkins, Caitlin A. Finney   +19 more
wiley   +1 more source

Extracellular matrix remodeling upregulates hippocampal neurogenic niche stiffness and impairs neurogenesis in Alzheimer's disease

Alzheimer's &Dementia, Volume 22, Issue 9, September 2026.
Abstract INTRODUCTION Preserving adult hippocampal neurogenesis alleviates cognitive deficits in Alzheimer's disease (AD), yet how biophysical alterations in such as stiffness in the neurogenic niche regulate neurogenesis remains unclear. METHODS Stiffness in the hippocampal dentate gyrus subgranular cell zone (SGZ) of 5×FAD mice was measured using ...
Weiqi Sun, Biyu Yang, Hanyuan Zheng, Qi Wang, Yajiao Shi, Gandig Wang, Wang Yin, Hui Wang, Xuetao Qi, Yun Yao, Jiaxin Wang, Shuang Cui, Kun Cui, Jian Mao, Yiyuan Xia, Jianwen Deng, Siyuan Zhao, Zhihao Wang, Fengyu Liu, Ming Yi, Jiuyang Ding, Weidong Le, Xinyan Li, Junliang Yuan, You Wan, Jie Zheng   +25 more
wiley   +1 more source

Neurobiological mechanisms of 40‐Hz stimulation in Alzheimer's disease: evidence, heterogeneity, and constraints

Alzheimer's &Dementia, Volume 22, Issue 9, September 2026.
Abstract Early disruption of gamma oscillations is increasingly recognized as a contributor to neurodegeneration and cognitive decline in Alzheimer's disease (AD), positioning 40‐Hz stimulation as a promising neuromodulatory strategy. However, its neurophysiological and cognitive effects remain highly variable across studies, underscoring the need for ...
Lin Qi, Weiye Wang, Reema Abdullah, Yilei Zhao, Zhibin Wang, Yi Tang, Benyan Luo, Guoping Peng   +7 more
wiley   +1 more source

Chemoenzymatic Synthesis of Well‐Defined α(2,8)‐ and α(2,9)‐Linked Oligosialosides

Angewandte Chemie, Volume 138, Issue 36, 1 September 2026.
Well‐defined α(2,8)‐ and α(2,9)‐linked oligosialic acids of different lengths can be prepared by employing recombinant bacterial polysialyltransferases in combination with chemically modified CMP‐Neu5Ac derivatives. After transfer, a sialoside is formed bearing an artificial entity, which blocks further glycosylation.
Jelle A. Fok, Keshav Kishor, Mehman I. Bunyatov, Gerlof P. Bosman, Geert‐Jan Boons   +4 more
wiley   +2 more sources