Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease, 2023 Background Transthyretin cardiac amyloidosis (ATTR‐CM), found in 6% to 15% of cohorts with heart failure with preserved ejection fraction, has long been considered a rare disease with poor prognosis.
Morris M. Kim +7 more
doaj +1 more source
Blood Reviews, 1988 Amyloidosis is a disorder of protein folding in which normally soluble proteins are deposited in the interstitial space as insoluble and remarkably stable fibrils that progressively disrupt tissue structure and function of organs throughout the body.
openaire +5 more sources
Nonbiopsy Diagnosis of Cardiac Transthyretin Amyloidosis
Circulation, 2016 Background— Cardiac transthyretin (ATTR) amyloidosis is a progressive and fatal cardiomyopathy for which several promising therapies are in development. The diagnosis is frequently delayed or missed because of the limited specificity of echocardiography ...
J. Gillmore +31 more
semanticscholar +1 more source
Senile Systemic Amyloidosis: Clinical Features at Presentation and Outcome [PDF]
, 2013 Background Cardiac amyloidosis is a fatal disease whose prognosis and treatment rely on identification of the amyloid type. In our aging population transthyretin amyloidosis (ATTRwt) is common and must be differentiated from other amyloid types.
Banypersad, SM +15 more
core +1 more source
High-precision plasma β-amyloid 42/40 predicts current and future brain amyloidosis
Neurology, 2019 Objective We examined whether plasma β-amyloid (Aβ)42/Aβ40, as measured by a high-precision assay, accurately diagnosed brain amyloidosis using amyloid PET or CSF p-tau181/Aβ42 as reference standards.
S. Schindler +11 more
semanticscholar +1 more source
Surgical treatment of a rare case of bilateral ptosis due to localized ocular amyloidosis [PDF]
, 2016 We describe a rare case of a 31-year old woman with bilateral ptosis due to localized amyloidosis. She referred a nine-year history of ptosis and surgical treatment with frontalis suspension three years previously.
ABDOLRAHIMZADEH, SOLMAZ +4 more
core +1 more source
Case Report and Literature Review of Cardiac Amyloidosis: A Not-So-Rare Cause of Heart Failure [PDF]
, 2023 Restrictive cardiomyopathy secondary to cardiac amyloidosis is an underdiagnosed cause of heart failure and it is associated with significant morbidity and mortality.
Alexandre, André +3 more
core +1 more source
The prevalence and distribution of the amyloidogenic transthyretin (TTR) V122I allele in Africa [PDF]
, 2016 Transthyretin (TTR) pV142I (rs76992529-A) is one of the 113 variants in the human TTR gene associated with systemic amyloidosis. It results from a G to A transition at a CG dinucleotide in the codon for amino acid 122 of the mature protein (TTR V122I ...
Alexander, Alice A +10 more
core +1 more source
Localised oral amyloidosis in the context of oral epithelial dysplasia:Literature review and report of two cases [PDF]
, 2022 Amyloidosis is a group of rare progressive diseases that occur as a result of abnormal protein folding and aggregation. Systemic amyloidosis is a serious disease with high mortality, and prompt diagnosis is key to improving prognosis.
Dobson, Marianne L. +3 more
core +1 more source
Light chain systemic amyloidosis manifested as liver failure complicated with fatal spontaneous splenic rupture: A case report [PDF]
arXiv, 2021 For a patient with manifestations of nausea, abdominal distension, spontaneous splenic rupture, obvious liver enlargement, low red blood cells and platelets, yellow sclera, and spider angioma, Congo red staining of liver and spleen tissues indicated amyloidosis.
arxiv