Results 61 to 70 of about 128,055 (353)
Solvent and mutation effects on the nucleation of amyloid $β$-protein folding [PDF]
Experimental evidence suggests that the folding and aggregation of the amyloid $\beta$-protein (A$\beta$) into oligomers is a key pathogenetic event in Alzheimer's disease (AD). Inhibiting the pathologic folding and oligomerization of A$\beta$ could be effective in the prevention and treatment of AD.
arxiv +1 more source
Branching Ionizable Lipids Can Enhance the Stability, Fusogenicity, and Functional Delivery of mRNA
Branched‐tail lipids are commonly used for the delivery of messenger RNA (mRNA). However, the exact role of the branched chains remains unclear. To address this, a lipid library is developed containing 32 different types of α‐branched tails. This library enables a systematic comparison and demonstrates that branched chains can enhance the stability ...
Kazuki Hashiba+9 more
wiley +1 more source
Transthyretin Cardiac Amyloidosis: A Cardio-Orthopedic Disease
Orthopaedic manifestations of wild-type transthyretin amyloidosis are frequent and characteristic, including idiopathic bilateral carpal tunnel syndrome, idiopathic lumbar canal stenosis, atraumatic rupture of the brachial biceps tendon, and, more rarely,
Federico Perfetto+9 more
doaj +1 more source
Aspects of structural landscape of human islet amyloid polypeptide [PDF]
The human islet amyloid polypeptide (hIAPP) co-operates with insulin to maintain glycemic balance. It also constitutes the amyloid plaques that aggregate in the pancreas of type-II diabetic patients. We have performed extensive in silico investigations to analyse the structural landscape of monomeric hIAPP, which is presumed to be intrinsically ...
arxiv +1 more source
Sex-specific effects of microbiome perturbations on cerebral Aβ amyloidosis and microglia phenotypes. [PDF]
We demonstrated that an antibiotic cocktail (ABX)-perturbed gut microbiome is associated with reduced amyloid-β (Aβ) plaque pathology and astrogliosis in the male amyloid precursor protein (APP)SWE /presenilin 1 (PS1)ΔE9 transgenic model of Aβ ...
Baufeld, Caroline+10 more
core +1 more source
Multimodal MRI-based Imputation of the Aβ+ in Early Mild Cognitive Impairment. [PDF]
ObjectiveTo identify brain atrophy from structural-MRI and cerebral blood flow(CBF) patterns from arterial spin labeling perfusion-MRI that are best predictors of the Aβ-burden, measured as composite 18F-AV45-PET uptake, in individuals with early mild ...
Joshi, Sarang+3 more
core +1 more source
Cell Membrane‐Coated Lipid Nanoparticles for Drug Delivery
This review highlights recent progress in cell membrane‐coated lipid nanoparticles (CMC‐LNPs), focusing on their design, preparation methods, functional integration, and biomedical applications. It discusses various types of LNPs and coating strategies, characterization techniques, therapeutic functions, and applications.
Moataz B. Zewail+5 more
wiley +1 more source
The complementary role of histology and proteomics for diagnosis and typing of systemic amyloidosis
The tissue diagnosis of amyloidosis and confirmation of fibril protein type, which are crucial for clinical management, have traditionally relied on Congo red (CR) staining followed by immunohistochemistry (IHC) using fibril protein specific antibodies ...
Tamer Rezk+12 more
doaj +1 more source
Background Idiopathic recurrent pericarditis (IRP) is an orphan disease that carries significant morbidity, partly driven by corticosteroid dependence.
Claire J. Peet+7 more
doaj +1 more source
Localised Laryngeal Amyloidosis Endoscopic Excision -A Case Report [PDF]
:We report a case of primary laryngeal amyloidosis in a 35 year old adult patient who presented with hoarseness of voice for 6 months duration with no other symptoms.
Sundhar Krishnan, Gurunathan+2 more
core +1 more source