Results 61 to 70 of about 181,705 (382)

Diagnosis and treatment of cardiac amyloidosis: position statement of the German Cardiac Society (DGK)

Clinical Research in Cardiology, 2021
Systemic forms of amyloidosis affecting the heart are mostly light-chain (AL) and transthyretin (ATTR) amyloidoses. The latter is caused by deposition of misfolded transthyretin, either in wild-type (ATTRwt) or mutant (ATTRv) conformation.
Yilmaz, Bauersachs, Bengel, Büchel, Kindermann, Klingel, Knebel, Meder, Morbach, Nagel, Schulze ‐ Bahr, Siepen, Frey   +12 more
semanticscholar   +1 more source

Senile Systemic Amyloidosis: Clinical Features at Presentation and Outcome [PDF]

, 2013
Background Cardiac amyloidosis is a fatal disease whose prognosis and treatment rely on identification of the amyloid type. In our aging population transthyretin amyloidosis (ATTRwt) is common and must be differentiated from other amyloid types.
Banypersad, SM, Dungu, J, Gibbs, SD, Gilbertson, JA, Gillmore, JD, Hawkins, PN, Lachmann, HJ, McCarthy, CA, Petrie, A, Pinney, JH, Rowczenio, D, Sattianayagam, P, Venner, CP, Wassef, N, Wechalekar, A, Whelan, CJ   +15 more
core   +1 more source

Systemic amyloidosis from A (AA) to T (ATTR): a review

Journal of Internal Medicine, 2020
Systemic amyloidosis is a rare protein misfolding and deposition disorder leading to progressive organ failure. There are over 15 types of systemic amyloidosis, each caused by a different precursor protein which promotes amyloid formation and tissue ...
Eli Muchtar, A. Dispenzieri, H. Magen, M. Grogan, M. Mauermann, E. McPhail, Paul J. Kurtin, N. Leung, F. Buadi, D. Dingli, S. Kumar, M. Gertz   +11 more
semanticscholar   +1 more source

Dataset on the use of 3D speckle tracking echocardiography in light-chain amyloidosis [PDF]

, 2018
The dataset presented in this article is related to the research article entitled “Biventricular assessment of light-chain amyloidosis using 3D speckle tracking echocardiography: Differentiation from other forms of myocardial hypertrophy” (Vitarelli et ...
Antonio Vitarelli, Carlo Gaudio, Enrico Mangieri, Federico Vozella, Giovanni Truscelli, Lidia Capotosto, Maria Teresa Petrucci, Mario Sergio Pergolini, Serafino Ricci, Silvia Lai, Simone De Sio   +10 more
core   +2 more sources

A retrospective study of isatuximab-pomalidomide-dexamethasone in relapsed/refractory systemic AL amyloidosis

Haematologica
Not available.
Sargam Rachit Vohra, Sriram Ravichandran, Darren Foard, Ana Martinez-Naharro, Lucia Venneri, Marianna Fontana, Carol J. Whelan, Philip N. Hawkins, Julian Gillmore, Helen J. Lachmann, Shameem Mahmood, Ashutosh D. Wechalekar   +11 more
doaj   +1 more source

Dissecting the Molecular Features of Systemic Light Chain (AL) Amyloidosis: Contributions from Proteomics

Medicina, 2021
Amyloidoses are characterized by aggregation of proteins into highly ordered amyloid fibrils, which deposit in the extracellular space of tissues, leading to organ dysfunction.
Paola Rognoni, Giulia Mazzini, Serena Caminito, Giovanni Palladini, Francesca Lavatelli   +4 more
doaj   +1 more source

Amyloid nomenclature 2018: recommendations by the International Society of Amyloidosis (ISA) nomenclature committee

Amyloid: Journal of Protein Folding Disorders, 2018
The nomenclature committee of the International Society of Amyloidosis (ISA) meets every second year to discuss and formulate recommendations. The conclusions from the discussion at the XVI International Symposium on Amyloidosis in Kumamoto, Japan, 25–29
M. Benson, J. Buxbaum, D. Eisenberg, G. Merlini, M. Saraiva, Y. Sekijima, J. Sipe, P. Westermark   +7 more
semanticscholar   +1 more source

A common beta-sheet architecture underlies in vitro and in vivo beta(2)-microglobulin amyloid fibrils [PDF]

, 2008
Misfolding and aggregation of normally soluble proteins into amyloid fibrils and their deposition and accumulation underlies a variety of clinically significant diseases.
Jahn, T.R., Radford, S.E., Tennent, G.A.
core   +2 more sources

Cardiac transplantation in transthyretin amyloid cardiomyopathy: Outcomes from three decades of tertiary center experience

Frontiers in Cardiovascular Medicine, 2023
AimsTransthyretin cardiac amyloidosis (ATTR-CM) is a progressive and fatal cardiomyopathy. Treatment options in patients with advanced ATTR-CM are limited to cardiac transplantation (CT).
Yousuf Razvi, Aldostefano Porcari, Aldostefano Porcari, Concetta Di Nora, Rishi K. Patel, Adam Ioannou, Muhammad U. Rauf, Ambra Masi, Steven Law, Liza Chacko, Tamer Rezk, Sriram Ravichandran, Janet Gilbertson, Dorota Rowczenio, Iona J. Blakeney, Nandita Kaza, David F. Hutt, Helen Lachmann, Ashutosh Wechalekar, William Moody, Sern Lim, Colin Chue, Carol Whelan, Lucia Venneri, Ana Martinez-Naharro, Marco Merlo, Gianfranco Sinagra, Ugolino Livi, Philip Hawkins, Marianna Fontana, Julian D. Gillmore   +30 more
doaj   +1 more source

Inotersen Treatment for Patients with Hereditary Transthyretin Amyloidosis

New England Journal of Medicine, 2018
BACKGROUND Hereditary transthyretin amyloidosis is caused by pathogenic single‐nucleotide variants in the gene encoding transthyretin (TTR) that induce transthyretin misfolding and systemic deposition of amyloid. Progressive amyloid accumulation leads to
M. Benson, M. Waddington-Cruz, J. Berk, M. Polydefkis, P. Dyck, Annabel K. Wang, V. Planté-Bordeneuve, F. Barroso, G. Merlini, L. Obici, M. Scheinberg, T. Brannagan, W. Litchy, C. Whelan, B. Drachman, D. Adams, S. Heitner, I. Conceição, H. Schmidt, G. Vita, J. Campistol, J. Gámez, P. Gorevic, E. Gane, A. Shah, S. Solomon, B. Monia, S. Hughes, J. Kwoh, B. McEvoy, Shiangtung W. Jung, B. Baker, E. Ackermann, M. Gertz, T. Coelho   +34 more
semanticscholar   +1 more source