Results 131 to 140 of about 235,642 (386)

Difficulties in diagnosing amyotrophic lateral sclerosis in a HIV-Positive Patient

Журнал инфектологии, 2018
We described a case of amyotrophic lateral sclerosis (ALS) with comorbid HIV infection. The diagnosis was confirmed by genetic tests. The difficulty of the differential diagnosis between amyotrophic lateral sclerosis and HIV-associated ALS syndrome is ...
T. M. Alekseeva, N. V. Skripchenko, S. V. Lobzin, V. S. Demeshonok, E. A. Yurkina, V. D. Nazarov, S. V. Lapin   +6 more
doaj   +1 more source

RNA Dysregulation in Amyotrophic Lateral Sclerosis

Frontiers in Genetics, 2019
Amyotrophic lateral sclerosis (ALS) is the most common adult-onset motor neuron disease and is characterized by the degeneration of upper and lower motor neurons.
Zoé Butti, S. A. Patten
semanticscholar   +1 more source

ATXN1 repeat expansions confer risk for amyotrophic lateral sclerosis and contribute to TDP-43 mislocalization

Brain Communications, 2020
Increasingly, repeat expansions are being identified as part of the complex genetic architecture of amyotrophic lateral sclerosis. To date, several repeat expansions have been genetically associated with the disease: intronic repeat expansions in C9orf72,
Gijs H. P. Tazelaar, S. Boeynaems, Mathias De Decker, J. V. van Vugt, L. Kool, H. S. Goedee, R. Mclaughlin, W. Sproviero, A. Iacoangeli, M. Moisse, M. Jacquemyn, D. Daelemans, Annelot M. Dekker, Rick A. A. van der Spek, H. Westeneng, K. Kenna, A. Assialioui, Nica Da Silva, M. Povedano, J. M. Pardina, O. Hardiman, F. Salachas, S. Millecamps, P. Vourc'h, P. Corcia, P. Couratier, K. Morrison, P. Shaw, C. Shaw, R. Pasterkamp, J. Landers, L. Van Den Bosch, W. Robberecht, A. Al-Chalabi, L. H. van den Berg, P. van Damme, J. Veldink, M. V. van Es   +37 more
semanticscholar   +1 more source

Polyhalogenated Carbazole Impairs Dopaminergic Neurons through Dysregulation of Liquid–Liquid Phase Separation in Caenorhabditis elegans

Advanced Science, EarlyView.
Polyhalogenated carbazoles (PHCZ), persistent environmental contaminants, preferentially accumulate in neuronal tissues. Studies using Caenorhabditis elegans and human neuronal cell lines reveal that PHCZ induce dopaminergic neurodegeneration by promoting liquid–liquid phase separation of α‐synuclein, reducing condensate fluidity, impairing ...
Yuhang Luo, Hongbo Xu, Pei Peng, Xinhe Lu, Qian Zhou, Ziqing Gao, Cheng Tang, Hongyan Yin, Ying Cai, Gaga Mahai, Zhiqiang Zhu, Zuojun Liu, Hanzeng Li, Shunqing Xu   +13 more
wiley   +1 more source

Exploring platelet metabolomics and fatty acid profiles for ALS prognosis and diagnosis

Scientific Reports
Amyotrophic lateral sclerosis (ALS) is a fatal neurodegenerative disease with heterogeneous clinical progression, reflecting distinct underlying pathological mechanisms.
Pascual Torres, Irene Pradas, Anna Fernàndez-Bernal, Mònica Povedano, Raul Dominguez, Mariona Jové, Cristina Gonzalez-Mingot, Victòria Ayala, Isidre Ferrer, Reinald Pamplona, Manuel Portero-Otin   +10 more
doaj   +1 more source

Dietary BMAA exposure in an amyotrophic lateral sclerosis cluster from southern France.

PLoS ONE, 2013
BackgroundDietary exposure to the cyanotoxin BMAA is suspected to be the cause of amyotrophic lateral sclerosis in the Western Pacific Islands. In Europe and North America, this toxin has been identified in the marine environment of amyotrophic lateral ...
Estelle Masseret, Sandra Banack, Farid Boumédiène, Eric Abadie, Luc Brient, Fabrice Pernet, Raoul Juntas-Morales, Nicolas Pageot, James Metcalf, Paul Cox, William Camu, French Network on ALS Clusters Detection and Investigation   +11 more
doaj   +1 more source

C9orf72 repeat expansions cause neurodegeneration in Drosophila through arginine-rich proteins [PDF]

, 2014
An expanded GGGGCC repeat in C9orf72 is the most common genetic cause of frontotemporal dementia and amyotrophic lateral sclerosis. A fundamental question is whether toxicity is driven by the repeat RNA itself and/or by dipeptide repeat proteins ...
Cabecinha, M, Clayton, EL, Cleverley, K, Devoy, A, Dols, J, Fisher, EMC, Fratta, P, Grönke, S, Hendrich, O, Isaacs, AM, Mizielinska, S, Moens, T, Niccoli, T, Nicoll, AJ, Norona, FE, Partridge, L, Pickering-Brown, S, Pietrzyk, J, Ridler, CE, Woollacott, IOC   +19 more
core   +1 more source

Targeting Multilayered Metabolic Networks in Brain Diseases: Emerging Perspectives on Nanodelivery Strategies

Advanced Science, EarlyView.
Brain diseases involve multilayered metabolic disruptions that reshape cellular interactions and microenvironments. This review outlines core metabolic features across disease states and presents emerging nanodelivery strategies as precision tools to reprogram pathological metabolism.
Jingyi Zhou, Chen Jiang
wiley   +1 more source

A Case of Amiotrophic Lateral Sclerosis Presenting with Daytime Excessive Sleepiness

Türk Uyku Tıbbı Dergisi, 2019
Amyotrophic lateral sclerosis is a neurodegenerative disease with progressive motor neuron degeneration in primary motor cortex, corticospinal pathways, brain stem and spinal cord.
Turgay Demir, Kezban Aslan, Mehmet Balal, Şebnem Bıçakcı   +3 more
doaj   +1 more source

Regulation of Neuroinflammation by Microglial DUBA‐IRAK1‐IKKβ Signaling Loop

Advanced Science, EarlyView.
The protein levels of deubiquitinating enzyme A (DUBA) are rapidly upregulated in microglia after activation of Toll‐like receptor 4 (TLR4). In turn, DUBA potentiates TLR4‐induced proinflammatory signal transduction in microglia by stabilizing interleukin‐1 receptor activated kinase 1 (IRAK1) through K48 deubiquitination.
Zhenhu Zhu, Zhongding Li, Kate Lykke Lambertsen, Zijun Cao, Meng Chen, Yanqi Xu, Bettina Hjelm Clausen, Keshuo Jin, Yiting Lu, Fuqi Mei, Xue Du, Kangmin Chen, Huiyuan Bai, Xian Su, Bincheng Zhou, Baohua Liu, Ran Li, Chaoqun Wang, Yuhua Li, Xiang Cai, Dirk Schlüter, Weihong Song, Xu Wang   +22 more
wiley   +1 more source