Results 131 to 140 of about 242,580 (385)

Targeting Microglial CD49a Inhibits Neuroinflammation and Demonstrates Therapeutic Potential for Parkinson's Disease

Advanced Science, EarlyView.
This study shows that integrin receptor CD49a (Itga1 gene) is significantly upregulated in hyperactivated microglia and microglia‐specific knockdown of Itga1 rescues neuroinflammation and neurodegeneration in a chronic Parkinson's disease (PD) model by targeting PGAM5‐mediated mitochondrial dysfunction and NLRP3 activation. Targeted inhibition of CD49a
Huanpeng Lu, Yunmin Zhu, Xi Wang, Zelin Wu, Zijian Xu, Rongqing Chen, Yanwu Guo   +6 more
wiley   +1 more source

Identification of potential drug targets for amyotrophic lateral sclerosis by Mendelian randomization analysis based on brain and plasma proteomics

Experimental Gerontology
Amyotrophic lateral sclerosis as a fatal neurodegenerative disease currently lacks effective therapeutic agents. Thus, finding new therapeutic targets to drive disease treatment is necessary.
Ni Yang, Liangyuan Shi, Pengfei Xu, Fang Ren, Chunlin Li, Xianghua Qi   +5 more
doaj   +1 more source

Increased in vivo glial activation in patients with amyotrophic lateral sclerosis: Assessed with [11C]-PBR28

NeuroImage: Clinical, 2015
Evidence from human post mortem, in vivo and animal model studies implicates the neuroimmune system and activated microglia in the pathology of amyotrophic lateral sclerosis.
Nicole R. Zürcher, Marco L. Loggia, Robert Lawson, Daniel B. Chonde, David Izquierdo-Garcia, Julia E. Yasek, Oluwaseun Akeju, Ciprian Catana, Bruce R. Rosen, Merit E. Cudkowicz, Jacob M. Hooker, Nazem Atassi   +11 more
doaj   +1 more source

Neuroprotective efficacy of aminopropyl carbazoles in a mouse model of amyotrophic lateral sclerosis [PDF]

, 2012
Rachel Tesla, Hamilton Parker Wolf, Pin Xu, Jordan Drawbridge, Sandi Jo Estill, Paula Huntington, Latisha McDaniel, Whitney Knobbe, Aaron Burket, Stephanie Tran, Ruth Starwalt, Lorraine Morlock, Jacinth Naidoo, Noelle S. Williams, Joseph M. Ready, Steven L. McKnight, Andrew A. Pieper   +16 more
openalex   +1 more source

Disrupted neuronal trafficking in amyotrophic lateral sclerosis

Acta Neuropathologica, 2019
Amyotrophic lateral sclerosis (ALS) is a progressive, adult-onset neurodegenerative disease caused by degeneration of motor neurons in the brain and spinal cord leading to muscle weakness.
K. Burk, R. Pasterkamp
semanticscholar   +1 more source

AI‐Driven Acceleration of Fluorescence Probe Discovery

Advanced Science, EarlyView.
We present PROBY, an AI model trained on large‐scale datasets to predict key photophysical properties and accelerate the discovery of target‐specific fluorescent probes. By screening a target‐annotated library, PROBY identifies candidate probes for diverse targets and could guide probe optimization, enabling a range of in vitro and in vivo imaging ...
Xuefeng Jiang, Yanbo Li, Xue Tian, Sen Yang, Ruina Luo, Cenxing Zhou, Yuxuan Liu, Jingying Hu, Sen Feng, Lu Gan, Chongzhao Ran, Kun‐Hsing Yu, Junhan Zhao, Xiao Han, Xuan Zhai, Yuntao Jia, Jiapei Dai, Xiyue Wang, Biyue Zhu   +18 more
wiley   +1 more source

An Investigation of Perspectives of Respite Admission Among People Living With Amyotrophic Lateral Sclerosis and the Hospitals That Support Them

Journal of Primary Care & Community Health, 2017
Background: Amyotrophic lateral sclerosis is a progressive disease with rapid degeneration. Respite care is an essential service for improving the well-being of both patients with this disease and their family caregivers, but accessibility of respite ...
Michiko Nakai, Yugo Narita, Hidekazu Tomimoto   +2 more
doaj   +1 more source

Shared polygenic risk and causal inferences in amyotrophic lateral sclerosis

Annals of Neurology, 2019
To identify shared polygenic risk and causal associations in amyotrophic lateral sclerosis (ALS).
S. Bandres-Ciga, A. Noyce, G. Hemani, A. Nicolas, A. Calvo, G. Mora, Alessandro Marco Ilaria Stefania Michele Giuseppe Maura Andre Arosio Barberis Bartolomei Battistini Benigni Borg, A. Arosio, M. Barberis, I. Bartolomei, S. Battistini, Michele Benigni, G. Borghero, M. Brunetti, A. Calvo, S. Cammarosano, A. Cannas, A. Canosa, M. Capasso, C. Caponnetto, Carla Caredda, Paola Carrera, F. Casale, S. Cavallaro, A. Chiò, T. Colletti, F. Conforti, A. Conte, L. Corrado, E. Costantino, S. D'alfonso, Antonio Fasano, C. Femiano, C. Ferrarese, N. Fini, G. Floris, G. Fuda, F. Giannini, M. Grassano, A. Ilardi, V. La Bella, S. Lattante, G. Logroscino, F. Logullo, D. Loi, C. Lunetta, G. Mancardi, P. Mandich, J. Mandrioli, U. Manera, G. Marangi, Kalliopi Marinou, G. Marrali, M. Marrosu, L. Mazzini, M. Melis, S. Messina, C. Moglia, M. Monsurrò, G. Mora, L. Mosca, Patrizia Occhineri, P. Origone, C. Pani, S. Penco, A. Petrucci, G. Piccirillo, A. Pirisi, Fabrizio Pisano, M. Pugliatti, G. Restagno, C. Ricci, Maria Rita Murru, N. Riva, M. Sabatelli, Fabrizio Salvi, M. Santarelli, Riccardo Sideri, I. Simone, R. Spataro, R. Tanel, G. Tedeschi, S. Tranquilli, L. Tremolizzo, F. Trojsi, P. Volanti, M. Zollino, Yevgeniya Sampath Robert H. Robert Christopher B. Alexis Jam Abramzon Arepalli Baloh Bowser Brady Brice Broach , Yevgeniya A. Abramzon, S. Arepalli, R. Baloh, R. Bowser, C. Brady, A. Brice, J. Broach, R. H. Campbell, W. Camu, Ruth Chia, Johnathan Cooper-Knock, D. Cusi, Jinhui Ding, C. Drepper, V. Drory, T. Dunckley, J. Eicher, F. Faghri, E. Feldman, Mary Kay Floeter, P. Fratta, Joshua T. Geiger, Glenn Gerhard, J. R. Gibbs, S. Gibson, J. Glass, J. Hardy, M. Harms, T. Heiman-Patterson, D. Hernandez, Lilja Jansson, F. Kamel, J. Kirby, N. Kowall, Hannu Laaksovirta, F. Landi, I. Le Ber, S. Lumbroso, D. Macgowan, N. Maragakis, K. Mouzat, N. Murphy, L. Myllykangas, M. Nalls, A. Nicolas, R. Orrell, L. Ostrow, R. Pamphlett, S. Pickering-Brown, E. Pioro, Hannah A. Pliner, S. Pulst, J. Ravits, A. Renton, Alberto M. Rivera, W. Robbrecht, E. Rogaeva, S. Rollinson, J. Rothstein, E. Salvi, Sonja W. Scholz, M. Sendtner, P. Shaw, K. Sidle, Z. Simmons, Andrew B. Singleton, David C. Stone, R. Sulkava, P. Tienari, B. Traynor, J. Trojanowski, J. Troncoso, P. van Damme, V. V. Van Deerlin, L. Van Den Bosch, L. Zinman, P. Tienari, David J. Stone, M. Nalls, Andrew B. Singleton, A. Chiò, B. Traynor   +169 more
semanticscholar   +1 more source

Alphaviral Capsid Proteins Inhibit Stress Granule Assembly via Competitive RNA Binding With G3BP1

Advanced Science, EarlyView.
Stress granules exert antiviral functions. This study illustrates a conserved function of alphaviral capsid proteins in modulating stress granules. Oligomerization mediated by a helical motif coupled with a positively charged intrinsically disordered region (IDR) directly competes with G3BP1 for RNA binding, thereby disrupting G3BP1‐RNA liquid–liquid ...
Yun Zhang, Yi Liu, Zhiying Yao, Haolong Lai, Xiaoxin Chen, Ziqiu Wang, Yiqiong Bao, Tingting Li, Xiaoming Zhou, Xiabin Chen, Peiguo Yang   +10 more
wiley   +1 more source

Etiogenic factors present in the cerebrospinal fluid from amyotrophic lateral sclerosis patients induce predominantly pro-inflammatory responses in microglia

Journal of Neuroinflammation, 2017
Background Microglial cell-associated neuroinflammation is considered as a potential contributor to the pathophysiology of sporadic amyotrophic lateral sclerosis.
Pooja-Shree Mishra, K. Vijayalakshmi, A. Nalini, T. N. Sathyaprabha, B. W. Kramer, Phalguni Anand Alladi, T. R. Raju   +6 more
doaj   +1 more source