Results 141 to 150 of about 235,642 (386)

Early exposure to environmental toxin contributes to neuronal vulnerability and axonal pathology in a model of familial ALS [PDF]

, 2011
Adult onset amyotrophic lateral sclerosis (ALS) arises due to progressive and irreversible functional deficits to the central nervous system, specifically the loss of motor neurons.
Christopher A. Shaw, Grace Lee
core   +1 more source

Structural and Functional Versatility of the Amyloidogenic Non‐Amidated Variant of the Antimicrobial Peptide Citropin 1.3

Advanced Science, EarlyView.
Citropin 1.3 is an antimicrobial peptide derived from amphibians that forms amyloid structures. Here, the structural and functional properties of citropin 1.3 are characterized. Using high‐resolution imaging approaches, a variety of canonical and undescribed fibril morphologies are identified.
Fabio Strati, Mariana Pigozzi Cali, Yehudi Bloch, Siavash Mostafavi, Jim Monistrol, Aleksandr Golubev, Bader Rayan, Emil Gustavsson, Meytal Landau   +8 more
wiley   +1 more source

Review of Prognostic Testing for Amyotrophic Lateral Sclerosis and Frontotemporal Dementia

Neurologijos seminarai
Frontotemporal dementia and amyotrophic lateral sclerosis are neurodegenerative diseases with distinc clinical presentation, but interconnected with each other.
Donata Pakeltytė, Birutė Burnytė
doaj   +1 more source

Increased in vivo glial activation in patients with amyotrophic lateral sclerosis: Assessed with [11C]-PBR28

NeuroImage: Clinical, 2015
Evidence from human post mortem, in vivo and animal model studies implicates the neuroimmune system and activated microglia in the pathology of amyotrophic lateral sclerosis.
Nicole R. Zürcher, Marco L. Loggia, Robert Lawson, Daniel B. Chonde, David Izquierdo-Garcia, Julia E. Yasek, Oluwaseun Akeju, Ciprian Catana, Bruce R. Rosen, Merit E. Cudkowicz, Jacob M. Hooker, Nazem Atassi   +11 more
doaj   +1 more source

Lactylation of HMGB1 at K177 Drives Nuclear Export of TIAR to Promote Hypoxia‐Induced Stress Granule Formation

Advanced Science, EarlyView.
This study uncovers a novel mechanism in which p300‑catalyzed lactylation of HMGB1 triggers nuclear export of the HMGB1‐TIAR complex, driving TIAR‐dependent SGs formation in the cytoplasm. Mass spectrometry and mutagenesis reveals that K177 lactylation is essential for this export and subsequent SGs formation.
Chengyu Li, Zhaojun Liu, Linjie Zhu, Gang Wu, Chen Fu, Hongmin Li, Tong He, Ming Shen, Honglin Liu   +8 more
wiley   +1 more source

BLOC1S1 Attenuates B. Melitensis 16M LPS‐Triggered Autophagy by Spatial Confinement of TDP‐43

Advanced Science, EarlyView.
This study explores how B. melitensis 16M LPS and BLOC1S1 regulate autophagy in goat spermatogonial stem cells. The 16M LPS is activating AMPK‐dependent autophagy, increasing LC3B‐II/I ratios and lysosomal genes, while Escherichia coli LPS shows no effect.
Shicheng Wan, Miao Han, Mengfei Zhang, Wenbo Chen, Fangde Xie, Xuan Luo, Wenping Wu, Congliang Wang, Donghui Yang, Bin Han, Haijing Zhu, Haisheng Yu, Na Li, Jinlian Hua   +13 more
wiley   +1 more source

INFANTILE AMYOTROPHIC LATERAL SCLEROSIS OF THE FAMILY TYPE [PDF]

, 1894
C. Brown
openalex   +1 more source

Understanding Disease Heterogeneity and Patient Characteristics in Patients with Amyotrophic Lateral Sclerosis (ALS) [PDF]

, 2019
Background: Amytrophic lateral sclerosis (ALS) is a fatal neurologic disease that is projected to double in worldwide incidence in the next 20 years.
Mathew, Veena
core  

Chronically Stable, High‐Resolution Micro‐Electrocorticographic Brain‐Computer Interfaces for Real‐Time Motor Decoding

Advanced Science, EarlyView.
A high‐resolution micro‐electrocorticographic (µECoG) brain‐computer interface (BCI) for real‐time motor decoding is reported. The application of flexible, scalable µECoG electrode arrays overcomes the insufficient spatial resolution in conventional ECoG BCIs.
Erda Zhou, Xiner Wang, Jizhi Liang, Yang Liu, Qinrong Yang, Xingchen Ran, Lei Xia, Xiang Zou, Changjiang Liu, Liuyang Sun, Lei Peng, Liang Chen, Ying Mao, Zehan Wu, Tiger H. Tao, Zhitao Zhou   +15 more
wiley   +1 more source

Identification of potential drug targets for amyotrophic lateral sclerosis by Mendelian randomization analysis based on brain and plasma proteomics

Experimental Gerontology
Amyotrophic lateral sclerosis as a fatal neurodegenerative disease currently lacks effective therapeutic agents. Thus, finding new therapeutic targets to drive disease treatment is necessary.
Ni Yang, Liangyuan Shi, Pengfei Xu, Fang Ren, Chunlin Li, Xianghua Qi   +5 more
doaj   +1 more source