Results 151 to 160 of about 242,580 (385)
Construction of pathogenic Sec16a mutation mouse model using CRISPR/Cas9
Animal Models and Experimental Medicine, EarlyView.Yaqiang Hu et al. engineered a pathogenic Sec16a mutant mouse model using CRISPR/Cas9 technology. They observed that the Sec16a mutant mice displayed diminished learning and memory capabilities, along with a limb‐clasping phenotype upon tail suspension.
Yaqiang Hu +6 more
wiley +1 more source
Frontostriatal deficit in Motor Neuron Disease/Amyotrophic Lateral Sclerosis (MND/ALS) [PDF]
, 2003 So far, cognitive derangements in MND/ALS have not been widely studied. Nevertheless, it seems that in subgroups of patients cognitive functions are impaired in different degree, so that often at least two sub-types of the syndrome are reported: Motor ...
Bongioanni, Dr. P +4 more
core
Espiritualidade e estratégias de coping religioso em um paciente com Esclerose Lateral Amiotrófica – Um relato de caso / Spirituality and Religious Coping Strategies in a Patient with Amyotrophic Lateral Sclerosis - A Case Report [PDF]
, 2021 Liliane Mary Andrade Silva +2 more
openalex +1 more source
Animal Models and Experimental Medicine, EarlyView.The increasing prevalence of dementia and related neurodegenerative diseases—including Alzheimer's disease, Parkinson's disease, multiple sclerosis, and amyotrophic lateral sclerosis—poses a growing public health challenge. These conditions have traditionally been studied as isolated central nervous system disorders, but emerging evidence points to ...
Osayd Zohud +3 more
wiley +1 more source
Annals of Neurology, EarlyView.Objective Mutations in TARDBP (encoding TDP‐43) are associated with the neurodegenerative disease amyotrophic lateral sclerosis (ALS) and include familial missense mutations where there are a lack of models and mechanisms examining how they are pathogenic.
Ziyaan A. Harji +10 more
wiley +1 more source
POSB356 Health-Related Quality of Life across King's and Mitos Stages Among Amyotrophic Lateral Sclerosis Patients: Results from a Real-World Point-in-Time Survey [PDF]
, 2022 K. Stenson +8 more
openalex +1 more source
Recent advances in the diagnosis and prognosis of amyotrophic lateral sclerosis
Lancet Neurology, 2022 Stephen A. Goutman +6 more
semanticscholar +1 more source
Annals of Neurology, EarlyView.Objective Biomarkers with clear contexts of use are important tools for amyotrophic lateral sclerosis (ALS) therapy development. Understanding their longitudinal trajectory in the untreated state is key to their use as potential markers of pharmacodynamic response.
Oleksandr Dergai +16 more
wiley +1 more source