Results 151 to 160 of about 235,642 (386)

INCIPIENT AMYOTROPHIC LATERAL SCLEROSIS, WITH RECOVERY. [PDF]

, 1902
LEO M. CRAFTS
openalex   +1 more source

The reunification of amyotrophic lateral sclerosis [PDF]

Journal of Neurology, Neurosurgery & Psychiatry, 2018
Historically characterised as a neuromuscular disease involving progressive loss of both central and peripheral motor neurons, amyotrophic lateral sclerosis (ALS) now sits among the cerebral neurodegenerative syndromes, involving clinical, pathological and genetic overlap with frontotemporal dementia (FTD).
openaire   +2 more sources

Redox Cascade in Chicken Skeletal Muscle: SELENOT Suppression in Selenium Deficiency Triggers Disulfidptosis via mtROS‐NADPH Dysregulation

Advanced Science, EarlyView.
Se deficiency downregulates SELENOT, disrupting mitochondrial function and elevating mtROS to induce glucose metabolic reprogramming, NADPH depletion, cysteine accumulation, and disulfidptosis‐mediated actin cytoskeleton collapse in chicken skeletal muscle.
Huanyi Liu, Hao Wu, Ziyu Zhang, Shiwen Xu, Cong Zhou, Tong Xu   +5 more
wiley   +1 more source

An Investigation of Perspectives of Respite Admission Among People Living With Amyotrophic Lateral Sclerosis and the Hospitals That Support Them

Journal of Primary Care & Community Health, 2017
Background: Amyotrophic lateral sclerosis is a progressive disease with rapid degeneration. Respite care is an essential service for improving the well-being of both patients with this disease and their family caregivers, but accessibility of respite ...
Michiko Nakai, Yugo Narita, Hidekazu Tomimoto   +2 more
doaj   +1 more source

Etiogenic factors present in the cerebrospinal fluid from amyotrophic lateral sclerosis patients induce predominantly pro-inflammatory responses in microglia

Journal of Neuroinflammation, 2017
Background Microglial cell-associated neuroinflammation is considered as a potential contributor to the pathophysiology of sporadic amyotrophic lateral sclerosis.
Pooja-Shree Mishra, K. Vijayalakshmi, A. Nalini, T. N. Sathyaprabha, B. W. Kramer, Phalguni Anand Alladi, T. R. Raju   +6 more
doaj   +1 more source

Disrupted neuronal trafficking in amyotrophic lateral sclerosis

Acta Neuropathologica, 2019
Amyotrophic lateral sclerosis (ALS) is a progressive, adult-onset neurodegenerative disease caused by degeneration of motor neurons in the brain and spinal cord leading to muscle weakness.
K. Burk, R. Pasterkamp
semanticscholar   +1 more source

Dnmt1 Alleviates S1PR1‐Mediated Pyroptosis after Spinal Cord Injury through Regulating Pon3 Expression

Advanced Science, EarlyView.
This study systematically explores the action mechanism of Pon3 and its regulatory targets in spinal cord injury (SCI). It demonstrates that Dnmt1 regulates Pon3 expression by modulating methylation levels, thereby inhibiting S1PR1‐mediated pyroptosis and improving SCI prognosis.
Birong Peng, Haolong Lin, Mi Zhang, Wenhao Kuang, Jiaqi Zhang, Shuai Wang, Yuanfang Sun, Wenning Xu, Lixin Zhu   +8 more
wiley   +1 more source

Dimer‐Specific FokT‐seq Reveals DNA‐Binding Dimerization and Novel Genomic Targets of TDP‐43

Advanced Science, EarlyView.
Loss of TDP‐43 dimerization is implicated in ALS, yet its mechanistic role remains elusive. This study introduces FokT, a novel system that restores TDP‐43 dimerization to map its DNA targets via FokT‐seq. The findings uncover key binding sites and offer a versatile tool for exploring dimer‐dependent transcriptional regulation.
Mingming Yang, Qi Wang, Ruolan Yan, Xiaochuan Wang, Jianlan Gu   +4 more
wiley   +1 more source

Medico-pedological studies on endemics: Chemical composition of soils in relation to amyotrophic lateral sclerosis in Kii Peninsula, Japan [PDF]

, 1967
Shuji Morita, Tomoo Hattori, Akira Aoki
openalex   +1 more source

Biomarkers in amyotrophic lateral sclerosis

The Lancet Neurology, 2009
Amyotrophic lateral sclerosis (ALS; motor neuron disease) is a relentlessly progressive disorder. After half a century of trials, only one drug with modest disease-modifying potency--riluzole--has been developed. The diagnosis of this disorder is still clinical and there is a pronounced delay between the onset of symptoms and diagnosis, possibly beyond
Turner, M, Kiernan, M, Leigh, P, Talbot, K   +3 more
openaire   +3 more sources