Results 171 to 180 of about 235,642 (386)
m6A Methylation‐Induced Autophagy Impairment by TFEB Regulation in SOD1‐G93A ALS Cell Model
American Journal of Medical Genetics Part B: Neuropsychiatric Genetics, EarlyView.ABSTRACT We investigate the role of m6A RNA methylation in regulating transcription factor EB (TFEB) and its contribution to mitochondrial autophagy (mitophagy) dysfunction in amyotrophic lateral sclerosis (ALS). ALS cell models were used to analyse mitophagy markers and TFEB expression under METTL3 and TFEB modulation, using RT‐qPCR, Western blot ...
Di An +7 more
wiley +1 more source
Kinesitherapy In Amyotrophic Lateral Sclerosis
Journal of Education, Health and Sport, 2017 summary in the ...
openaire +3 more sources
Construction of pathogenic Sec16a mutation mouse model using CRISPR/Cas9
Animal Models and Experimental Medicine, EarlyView.Yaqiang Hu et al. engineered a pathogenic Sec16a mutant mouse model using CRISPR/Cas9 technology. They observed that the Sec16a mutant mice displayed diminished learning and memory capabilities, along with a limb‐clasping phenotype upon tail suspension.
Yaqiang Hu +6 more
wiley +1 more source
Language impairments in ALS/MND (Amyotrophic Lateral Sclerosis/Motor Neuron Disease) [PDF]
, 2002 Paolo Bongioanni §, Giancarlo Buoiano C§, Marzia Magoni § § Neuroscience Dpt., Univ. Of Pisa, Italy c Corresponding author: Giancarlo Buoiano Via del Morello 8 Bargecchia I-55040 Corsanico (LU) email: giancarlo@neurolinguistics.0catch.com Language ...
Bongioanni, Dr. Paolo +2 more
core
Toward Natural Limb Function: A New Era in Prosthetic Innovation
Annals of Neurology, EarlyView.The past decade has witnessed groundbreaking clinical implementation of neuroprosthetic limbs driven by signals from peripheral targets (eg, nerves and muscle) and the brain to restore limb function for individuals with limb loss or impairment. In this review, we highlight recent key clinical trials in peripheral neuroprosthetic interfaces directly ...
Yucheng Tian +4 more
wiley +1 more source
Amyotrophic Lateral Sclerosis: From Disease Mechanisms to Therapies
BioTechniques, 2002 Lucie I. Bruijn
doaj +1 more source
Annals of Neurology, EarlyView.Objective Biomarkers of disease pathogenesis are critically needed for amyotrophic lateral sclerosis (ALS) to facilitate diagnosis and patient stratification into appropriate therapeutic trials. Proteomic studies offer significant potential to advance this, but reproducibility across laboratories is a key component toward identifying protein changes ...
Gabrielle L. Adler +2 more
wiley +1 more source
Amyotrophic lateral sclerosis as a synaptopathy
Neural Regeneration Research, 2019 The synapse is an incredibly specialized structure that allows for the coordinated communication of information from one neuron to another. When assembled into circuits, steady streams of excitatory and inhibitory synaptic activity shape neural outputs.
openaire +5 more sources
Annals of Neurology, EarlyView.Objective Despite its clinical heterogeneity, amyotrophic lateral sclerosis is unified by early and prominent alterations in cortical excitability, increasingly recognized as contributors to disease progression. This study assessed whether the ratio between motor evoked potential (MEP) amplitude, reflecting upper motor neuron integrity, and compound ...
Federico Ranieri +41 more
wiley +1 more source