Results 171 to 180 of about 242,580 (385)

A Novel Acetylcholine Nanosensor for Single Vesicle Storage and Sub‐Quantal Exocytosis in Living Neurons and Organoids

Angewandte Chemie, EarlyView.
Schematic representation of M@E@CF nanosensors for detecting vesicular storage and release in cholinergic neurons and brain organoids. (A) Nano‐tip microelectrodes modification via molds fabricated through 3D printing. (B) the reaction mechanism for acetylcholine detection at the electrode interface.
Wanying Zhu, Yufan Zhang, Hanwen Yu, Da Wang, Xinyue Zhang, Xiaowen Du, Shanshan Wu, Bingzhi Li, Yizhou Zhang, Hongliang Xin, Xing Guo, Yan Liu   +11 more
wiley   +2 more sources

Anatomical Associations Between Focal Mitochondrial Metabolism and Patterns of Neurodegeneration in Amyotrophic Lateral Sclerosis

Annals of Neurology, EarlyView.
Objective Amyotrophic lateral sclerosis (ALS) has a very specific neuroimaging signature, but the molecular underpinnings of the strikingly selective anatomic involvement have not elucidated to date. Accordingly, a large neuroimaging study was conducted with 258 participants to evaluate associations between patterns of neurodegeneration and focal ...
Marlene Tahedl, We Fong Siah, Efstratios Karavasilis, Jennifer C. Hengeveld, Mark A. Doherty, Russell L. McLaughlin, Orla Hardiman, Ee Ling Tan, Foteini Christidi, Jana Kleinerova, Peter Bede   +10 more
wiley   +1 more source

Administration of 4-(α-L-Rhamnosyloxy)-benzyl Isothiocyanate Delays Disease Phenotype in SOD1^G93ARats: A Transgenic Model of Amyotrophic Lateral Sclerosis [PDF]

, 2015
Maria Galuppo, Sabrina Giacoppo, Renato Iori, Gina Rosalinda De Nicola, Placido Bramanti, Emanuela Mazzon   +5 more
openalex   +1 more source

TDP-43 Mutations in Familial and Sporadic Amyotrophic Lateral Sclerosis

Science, 2008
J. Sreedharan, I. Blair, V. Tripathi, Xun Hu, C. Vance, B. Rogelj, S. Ackerley, S. Ackerley, J. Durnall, K. Williams, E. Buratti, F. Baralle, J. Belleroche, J. Mitchell, P. Leigh, A. Al-Chalabi, C. Miller, C. Miller, Garth A. Nicholson, Garth A. Nicholson, C. Shaw   +20 more
semanticscholar   +1 more source

The Epidemiology of Primary Lateral Sclerosis: Results from a Population‐Based Cohort

Annals of Neurology, EarlyView.
Objective In this population‐based study, we described the epidemiology of primary lateral sclerosis (PLS) in northern Italy and compared the clinical characteristics of patients with PLS to those with predominant upper motor neuron (PUMN) involvement and classic amyotrophic lateral sclerosis (ALS).
Rosario Vasta, Enrico Matteoni, Giorgio Pellegrino, Antonio Canosa, Umberto Manera, Francesca Palumbo, Maurizio Grassano, Sara Cabras, Alessandra Maccabeo, Fabrizio D'Ovidio, Gabriele Mora, Salvatore Gallone, Elisa D'Angelo, Letizia Mazzini, Fabiola De Marchi, Cristina Moglia, Adriano Chiò, Andrea Calvo   +17 more
wiley   +1 more source

Mortality associated with periodic limb movements during sleep in amyotrophic lateral sclerosis patients

Einstein (São Paulo)
OBJECTIVE: To describe the prevalence and severity of periodic limb movements during sleep in amyotrophic lateral sclerosis patients and to explore this fact as a predictor of severity of the condition with respect to mortality.
Alexander Joseph Moszczynski, Anu Tandon, Fernando Morgadinho Santos Coelho, Lorne Zinman, Brian Murray   +4 more
doaj   +1 more source

CSF and blood biomarkers in amyotrophic lateral sclerosis: protocol for a systematic review and meta-analysis [PDF]

, 2018
Elmira Agah, Fatemeh Saleh, Hossein Sanjari Moghaddam, Amene Saghazadeh, Abbas Tafakhori, Nima Rezaei   +5 more
openalex   +1 more source

Electronic Health Records to Test Multimorbidity Influences to Plasma Biomarker Interpretation for Alzheimer's Disease

Annals of Neurology, EarlyView.
Objective Plasma biomarkers of Alzheimer's disease (AD) pathology are frequently tested in specialized research settings, which limits the generalizability of findings. Using electronic health records and banked plasma, we evaluated plasma biomarkers—phosphorylated tau 217 (p‐tau217), β‐amyloid 1–42/1–40 (Aβ42/Aβ40) and p‐tau217/Aβ42—in a real‐world ...
Katheryn A.Q. Cousins, Rory Boyle, Colleen Morse, Anurag Verma, Christopher A. Brown, Kyra S. O'Brien, Marina Serper, Nadia Dehghani, Penn Medicine BioBank, Corey T. McMillan, Edward B. Lee, Leslie M. Shaw, David A. Wolk   +12 more
wiley   +1 more source

A new zebrafish model produced by TILLING of SOD1-related amyotrophic lateral sclerosis replicates key features of the disease and represents a tool for in vivo therapeutic screening

, 2013
Marc Da Costa, Claire Allen, Adrian Higginbottom, Tennore Ramesh, Pamela J. Shaw, Christopher McDermott   +5 more
openalex   +1 more source

Mutations in FUS, an RNA Processing Protein, Cause Familial Amyotrophic Lateral Sclerosis Type 6

Science, 2009
C. Vance, B. Rogelj, T. Hortobágyi, K. D. Vos, A. Nishimura, J. Sreedharan, Xun Hu, Bradley N. Smith, D. Ruddy, Paul Wright, J. Ganesalingam, K. Williams, V. Tripathi, Safa Al-Saraj, A. Al-Chalabi, P. Leigh, I. Blair, Garth A. Nicholson, Garth A. Nicholson, J. Belleroche, J. Gallo, C. Miller, C. Miller, C. Shaw   +23 more
semanticscholar   +1 more source