Results 11 to 20 of about 235,642 (386)

Amyloid Oligomers: A Joint Experimental/Computational Perspective on Alzheimer’s Disease, Parkinson’s Disease, Type II Diabetes, and Amyotrophic Lateral Sclerosis

Chemical Reviews, 2021
Protein misfolding and aggregation is observed in many amyloidogenic diseases affecting either the central nervous system or a variety of peripheral tissues.
Ayyalusamy Ramamoorthy, Jie Zheng, Peter Faller   +2 more
exaly   +2 more sources

A patient with amyotrophic lateral sclerosis and atypical clinical and electrodiagnostic features: a case report [PDF]

Journal of Medical Case Reports, 2011
Introduction Amyotrophic lateral sclerosis is a rapidly progressive, fatal neurodegenerative disorder for which there is no effective treatment. The diagnosis is dependent on the clinical presentation and consistent electrodiagnostic studies.
Venizelos Alexander, Park Youngsook, Fisher Morris A   +2 more
doaj   +3 more sources

Amyotrophic lateral sclerosis [PDF]

Nature Reviews Disease Primers, 2022
Amyotrophic lateral sclerosis (ALS), also known as motor neuron disease, is characterized by the degeneration of both upper and lower motor neurons, which leads to muscle weakness and eventual paralysis. Until recently, ALS was classified primarily within the neuromuscular domain, although new imaging and neuropathological data have indicated the ...
E. Feldman, Stephen A. Goutman, S. Petri, L. Mazzini, M. G. Savelieff, P. Shaw, G. Sobue   +6 more
semanticscholar   +10 more sources

Amyotrophic Lateral Sclerosis [PDF]

, 2019
The word amyotrophic is derived from Greek, and means “without nourishment to muscles”, lateral means to the sides and sclerosis means hardened (“What is ALS?,” n.d.).
Georgetson, Anastasia M.
core   +4 more sources

Cervical Spondylotic Myelopathy Mimicking ALS [PDF]

Indian Journal of Physical Medicine & Rehabilitation, 2008
Cervical spondylotic myelopathy presenting with muscle wasting in upper extremities and insignificantsensory loss has been termed as cervical spondylotic amyotrophy. This condition has to be differentiatedfrom Amyotrophic lateral sclerosis which also has
Subramaniam PC, Kumar R, Biswas A
doaj   +2 more sources

Amyotrophic Lateral Sclerosis. [PDF]

New England Journal of Medicine, 2017
Amyotrophic lateral sclerosis is characterised by the progressive loss of motor neurons in the brain and spinal cord. This neurodegenerative syndrome shares pathobiological features with frontotemporal dementia and, indeed, many patients show features of both diseases. Many different genes and pathophysiological processes contribute to the disease, and
Robert H. Brown, A. Al-Chalabi
semanticscholar   +13 more sources

G-CSF Prevents the Progression of Structural Disintegration of White Matter Tracts in Amyotrophic Lateral Sclerosis: A Pilot Trial [PDF]

, 2011
Background: The hematopoietic protein Granulocyte-colony stimulating factor (G-CSF) has neuroprotective and regenerative properties. The G-CSF receptor is expressed by motoneurons, and G-CSF protects cultured motoneuronal cells from apoptosis.
A Nitkunan, A Schneider, AA Gouw, AA Gouw, Agnes Floel, Armin Schneider, B Nefussy, BR Brooks, BR Brooks, BR Stanton, C Pitzer, C Tarella, Christoph Kleinschnitz, D Le Bihan, DM Mezzapesa, E Canu, F Agosta, F Agosta, F Schiavone, G Alon, G Fein, Hagen Schiffbauer, Harald Kugel, J Grosskreutz, J Minnerup, J Phukan, J Senda, JD Mitchell, JS Henkel, Katja Kolpatzik, M Deppe, M Filippi, M Mascalchi, M O'Sullivan, M Sach, M Swash, M Tanaka, MC Ng, MD Lezak, Michael Deppe, MJ Muller, MM van der Graaff, MR Turner, MT Giordana, N Cashman, NK Iwata, R Dengler, R Yamasaki, RA Charlton, RA Charlton, RG Miller, S Abrahams, S Zoccolella, SH Kim, Siawoosh Mohammadi, SM Smith, Stefan Knecht, T Duning, T Pyra, Thomas Duning, Tobias Warnecke, V Kavcic, Wolf Rüdiger Schäbitz, WR Schabitz, Y Zhang   +64 more
core   +20 more sources

Limits of and Alternatives to Conventional Medicine in the Context of Terminal Illness (e.g., Palliative Care)

Ethics in Progress, 2022
This paper aims at analysing the evolution of palliative care in the international context and their role in the path of care for the patient and the family.
Stefania Bastianello, Daniela Antonella Cattaneo   +1 more
doaj   +1 more source

The experience of children with a parent suffering from Amyotrophic Lateral Sclerosis during the COVID-19 pandemic

Scientific Reports, 2021
Children that have a parent with Amyotrophic Lateral Sclerosis (ALS) suffer from the progressive loss of their beloved ones. During the COVID-19 pandemic, the difficulties faced by these children have increased.
Ines Testoni, Lorenza Palazzo, Lucia Ronconi, Gabriella Rossi, Jenny Ferizoviku, Jose Ramon Pernia Morales   +5 more
doaj   +1 more source

Amyotrophic lateral sclerosis: a neurodegenerative disorder poised for successful therapeutic translation

Nature reviews. Drug discovery, 2022
Amyotrophic lateral sclerosis (ALS) is a devastating disease caused by degeneration of motor neurons. As with all major neurodegenerative disorders, development of disease-modifying therapies has proven challenging for multiple reasons. Nevertheless, ALS
R. Mead, N. Shan, H. Reiser, F. Marshall, P. Shaw   +4 more
semanticscholar   +1 more source