Results 11 to 20 of about 148,501 (250)

Creatine kinase in the diagnosis and prognostic prediction of amyotrophic lateral sclerosis: a retrospective case-control study

Neural Regeneration Research, 2021
Creatine kinase is a muscle enzyme that has been reported at various levels in different studies involving patients with amyotrophic lateral sclerosis.
Xue-Ping Chen, Qian-Qian Wei, Ru-Wei Ou, Yan-Bing Hou, Ling-Yu Zhang, Xiao-Qin Yuan, Yun-Qian Yao, De-Sheng Jia, Qian Zhang, Wei-Xue Li, Hui-Fang Shang   +10 more
doaj   +1 more source

Common and rare variant association analyses in amyotrophic lateral sclerosis identify 15 risk loci with distinct genetic architectures and neuron-specific biology

Nature Genetics, 2021
Amyotrophic lateral sclerosis (ALS) is a fatal neurodegenerative disease with a lifetime risk of one in 350 people and an unmet need for disease-modifying therapies.
W. V. Rheenen, Rick A. A. van der Spek, Mark K. Bakker, J. Vugt, P. Hop, R. Zwamborn, N. D. Klein, H. Westra, O. Bakker, Patrick Deelen, Gemma L Shireby, E. Hannon, M. Moisse, D. Baird, Restuadi Restuadi, E. Dolzhenko, Annelot M. Dekker, Klara Gawor, H. Westeneng, Gijs H. P. Tazelaar, K. V. van Eijk, M. Kooyman, Ross P. Byrne, Mark A. Doherty, M. Heverin, A. A. Khleifat, A. Iacoangeli, A. Shatunov, N. Ticozzi, Johnathan Cooper-Knock, Bradley N. Smith, M. Gromicho, S. Chandran, S. Pal, K. Morrison, P. Shaw, J. Hardy, R. Orrell, M. Sendtner, Thomas Meyer, Nazlı A Başak, A. J. van der Kooi, A. Ratti, I. Fogh, C. Gellera, Giuseppe Lauria Pinter, S. Corti, Cristina Cereda, D. Sproviero, S. D'alfonso, G. Soraru', G. Siciliano, M. Filosto, A. Padovani, A. Chiò, A. Calvo, C. Moglia, M. Brunetti, A. Canosa, M. Grassano, E. Beghi, E. Pupillo, G. Logroscino, B. Nefussy, Alma Osmanovic, Angelica Nordin, Y. Lerner, Michal Zabari, M. Gotkine, R. Baloh, S. Bell, P. Vourc'h, P. Corcia, P. Couratier, S. Millecamps, V. Meininger, F. Salachas, J. M. Pardina, A. Assialioui, R. Rojas‐García, P. Dion, J. Ross, A. Ludolph, Jochen H Weishaupt, David Brenner, A. Freischmidt, G. Bensimon, A. Brice, A. Dürr, C. Payan, Safa Saker-Delye, N. Wood, S. Topp, R. Rademakers, L. Tittmann, W. Lieb, A. Franke, S. Ripke, A. Braun, J. Kraft, D. Whiteman, C. Olsen, A. Uitterlinden, A. Hofman, M. Rietschel, S. Cichon, M. Nöthen, P. Amouyel, B. Traynor, A. Singleton, Miguel Mitne Neto, Ruben J. Cauchi, R. Ophoff, M. Wiedau-Pazos, C. lomen-Hoerth, V. V. Van Deerlin, J. Grosskreutz, A. Rödiger, N. Gaur, Alexander Jörk, Tabea Barthel, Erik Theele, B. Ilse, B. Stubendorff, O. Witte, R. Steinbach, C. Hübner, C. Graff, L. Brylev, V. Fominykh, V. Demeshonok, A. Ataulina, B. Rogelj, B. Koritnik, J. Zidar, M. Ravnik-Glavač, D. Glavač, Z. Stevic, V. Drory, M. Povedano, I. Blair, M. Kiernan, Beben Benyamin, R. Henderson, S. Furlong, S. Mathers, P. Mccombe, M. Needham, S. Ngo, G. Nicholson, R. Pamphlett, D. Rowe, F. Steyn, K. Williams, K. Mather, P. Sachdev, A. Henders, L. Wallace, M. Carvalho, S. Pinto, S. Petri, Markus Weber, G. Rouleau, V. Silani, C. Curtis, G. Breen, J. Glass, Robert H. Brown, J. Landers, C. Shaw, P. Andersen, E. Groen, M. A. Es, R. Pasterkamp, Dongsheng Fan, F. Garton, A. McRae, G. Davey Smith, T. Gaunt, M. Eberle, J. Mill, R. Mclaughlin, O. Hardiman, K. Kenna, N. Wray, E. Tsai, H. Runz, L. Franke, A. Al-Chalabi, P. Damme, L. H. van den Berg, J. Veldink   +191 more
semanticscholar   +1 more source

Amyotrophic Lateral Sclerosis

, 2020
Chapter to be included in the volume Pragmatic Language Disorders: Complex and Underserved Populations, Ed. Louise Cummings, Springer, 2020. It reviews findings that have contributed to our understanding of pragmatic impairment in ALS.
Ceroni, Mauro, Bambini , Valentina
openaire   +6 more sources

Lower and upper motor neuron involvement and their impact on disease prognosis in amyotrophic lateral sclerosis

Neural Regeneration Research, 2022
Amyotrophic lateral sclerosis is a fatal neurodegenerative disease characterized by progressive muscle wasting, breathing and swallowing difficulties resulting in patient’s death in two to five years after disease onset. In amyotrophic lateral sclerosis,
Maria N Zakharova, Anna A Abramova
doaj   +1 more source

Early Referral to an ALS Center Reduces Several Months the Diagnostic Delay: A Multicenter-Based Study

Frontiers in Neurology, 2020
Objective: To analyze those factors contributing to the diagnostic delay in ALS.Methods: Consecutive ALS patients were categorized as those studied in departmental hospitals and those studied in a referral ALS center.
Marina Martínez-Molina, Marina Martínez-Molina, Herminia Argente-Escrig, Herminia Argente-Escrig, Margarita F. Polo, David Hervás, Marina Frasquet, Marina Frasquet, Victoria Cortés, Teresa Sevilla, Teresa Sevilla, Teresa Sevilla, Teresa Sevilla, Juan F. Vázquez-Costa, Juan F. Vázquez-Costa, Juan F. Vázquez-Costa, Juan F. Vázquez-Costa   +16 more
doaj   +1 more source

Amyotrophic lateral sclerosis: a clinical review

European Journal of Neurology, 2020
Amyotrophic lateral sclerosis (ALS) is a neurodegenerative disorder affecting primarily the motor system, but in which extra‐motor manifestations are increasingly recognized.
Pegah Masrori, P. van Damme
semanticscholar   +1 more source

Altered SOD1 maturation and post-translational modification in amyotrophic lateral sclerosis spinal cord

Brain : a journal of neurology, 2022
Aberrant self-assembly and toxicity of wild-type and mutant superoxide dismutase 1 (SOD1) has been widely examined in silico, in vitro and in transgenic animal models of amyotrophic lateral sclerosis.
B. G. Trist, Sian Genoud, Stéphane Roudeau, Alexander Rookyard, Amr H. Abdeen, Veronica Cottam, D. Hare, Melanie Y. White, Jens Altvater, J. Fifita, A. Hogan, N. Grima, I. Blair, K. Kysenius, P. Crouch, A. Carmona, Yann Rufin, S. Claverol, Stijn J. M. Van Malderen, G. Falkenberg, D. Paterson, Bradley N. Smith, C. Troakes, C. Vance, C. Shaw, S. Al-Sarraj, S. Cordwell, G. Halliday, R. Ortega, K. Double   +29 more
semanticscholar   +1 more source

Amyotrophic lateral sclerosis

The Lancet, 2011
Amyotrophic lateral sclerosis (ALS) is an idiopathic, fatal neurodegenerative disease of the human motor system. In this Seminar, we summarise current concepts about the origin of the disease, what predisposes patients to develop the disorder, and discuss why all cases of ALS are not the same.
Kiernan, M, Vucic, S, Cheah, B, Turner, M, Eisen, A, Hardiman, O, Burrell, JR, Zoing, M   +7 more
openaire   +5 more sources

[Amyotrophic lateral sclerosis]. [PDF]

Nederlands tijdschrift voor tandheelkunde, 2010
Amyotrophic lateral sclerosis is one of the most severe and disabling diseases of the nervous system. Amyotrophic lateral sclerosis leads to the progressive weakening of the muscles in the arms, legs, face, mouth and trunk. The onset of the disease is insidious, starting with weakness in the hands or feet or with slurred speech.
Veldink, J.H., Weikamp, J.G., Schelhaas, H.J., Berg, L.H. van den   +3 more
  +8 more sources

Amyotrophic lateral sclerosis viewed from a patient’s perspective

Monaldi Archives for Chest Disease, 2016
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M. Melazzini
doaj   +1 more source