Results 221 to 230 of about 235,642 (386)

Caspase-1 is activated in neural cells and tissue with amyotrophic lateral sclerosis-associated mutations in copper-zinc superoxide dismutase [PDF]

, 1998
Piera Pasinelli, David Borchelt, Megan K. Houseweart, Don W. Cleveland, Robert H. Brown   +4 more
openalex   +1 more source

Amyotrophic lateral sclerosis - frontotemporal spectrum disorder (ALS-FTSD): Revised diagnostic criteria

Amyotrophic Lateral Sclerosis and Frontotemporal Degeneration, 2017
M. Strong, S. Abrahams, L. Goldstein, S. Woolley, P. McLaughlin, J. Snowden, E. Mioshi, A. Roberts-South, M. Benatar, T. Hortobágyi, J. Rosenfeld, V. Silani, P. Ince, M. R. Turner   +13 more
semanticscholar   +1 more source

C9orf72 Repeat Expansion Induces Metabolic Dysfunction in Human iPSC‐Derived Microglia and Modulates Glial‐Neuronal Crosstalk

Glia, EarlyView.
C9orf72 microglia display heightened glycolysis and oxidative stress, driving astrocytic reprogramming that impacts motor neurons. iPSC tricultures uncover key glial–neuronal interactions in C9orf72 pathology. ABSTRACT The C9orf72 hexanucleotide repeat expansion mutation is the most common genetic cause of amyotrophic lateral sclerosis (ALS) and ...
Marika Mearelli, Insa Hirschberg, Christin Weissleder, Carmela Giachino, María José Pérez, Malvina Dubroux, Francesca Provenzano, Mafalda Rizzuti, Linda Ottoboni, Udit Sheth, Tania F. Gendron, Stefania Corti, Michela Deleidi   +12 more
wiley   +1 more source

Sleep alterations in amyotrophic lateral sclerosis. [PDF]

Curr Opin Neurol
Lang C.
europepmc   +1 more source

Altered Inflammatory Signature in a C9ORF72‐ALS iPSC‐Derived Motor Neuron and Microglia Coculture Model

Glia, EarlyView.
Established a C9ORF72 ALS microglia and motor neuron coculture model. Identified an altered inflammatory signature in C9ORF72 ALS microglia. Single‐cell RNA sequencing detected the removal of an LPS responsive microglia subpopulation. ABSTRACT Amyotrophic lateral sclerosis (ALS) is a complex neurodegenerative disorder involving multiple cell types in ...
Yujing Gao, Jessica L. Brothwood, Harpreet Saini, Gregory A. O'Sullivan, Carla F. Bento, James M. McCarthy, Nicola G. Wallis, Elena Di Daniel, Brent Graham, Daniel M. Tams   +9 more
wiley   +1 more source

Exome sequencing in amyotrophic lateral sclerosis identifies risk genes and pathways

Science, 2015
Elizabeth T. Cirulli, Brittany N. Lasseigne, S. Petrovski, P. Sapp, P. Dion, C. Leblond, Julien Couthouis, Yi-Fan Lu, Quanli Wang, Brian J. Krueger, Z. Ren, Jonathan E. M. Keebler, Yujun Han, S. Levy, B. Boone, Jack R. Wimbish, L. Waite, Angela L. Jones, J. Carulli, A. Day-Williams, J. Staropoli, W. Xin, A. Chesi, Alya R. Raphael, D. McKenna-Yasek, J. Cady, J. M. B. Vianney de Jong, K. Kenna, Bradley N. Smith, S. Topp, Jack W. Miller, A. Gkazi, A. Al-Chalabi, L. H. van den Berg, J. Veldink, V. Silani, N. Ticozzi, C. Shaw, R. Baloh, S. Appel, E. Simpson, C. Lagier-Tourenne, S. Pulst, S. Gibson, J. Trojanowski, L. Elman, L. McCluskey, M. Grossman, N. Shneider, W. Chung, J. Ravits, J. Glass, K. Sims, V. V. Van Deerlin, T. Maniatis, Sebastian Hayes, A. Ordureau, Sharan Swarup, J. Landers, F. Baas, A. Allen, R. Bedlack, J. Harper, A. Gitler, G. Rouleau, Robert H. Brown, M. Harms, G. Cooper, Tim Harris, R. Myers, D. Goldstein   +70 more
semanticscholar   +1 more source

Oligodendroglial Densities and Myelin Structure Are Altered in TDP‐43 Related Amyotrophic Lateral Sclerosis

Glia, EarlyView.
TDP‐43Q331K mice exhibit altered proliferative dynamics in oligodendrocytes and their precursors. Oligodendroglial cell death is evident in TDP‐43Q331K mice. TDP‐43Q331K mice display altered myelin reflectance and pathology in the spinal cord. ABSTRACT Amyotrophic Lateral Sclerosis (ALS) is a fatal neurodegenerative disease characterized by the ...
Katherine N. Lewis, Georgina A. Craig, Joel Mason, Doris Tomas, Brittany Cuic, Adam K. Walker, David G. Gonsalvez, Bradley J. Turner, Samantha K. Barton   +8 more
wiley   +1 more source

Macroglossia Caused by Venous Congestion in a Patient With Amyotrophic Lateral Sclerosis. [PDF]

Clin Case Rep
Hino S, Iijima Y, Nakayama N, Horie N, Kaneko T.   +4 more
europepmc   +1 more source

Novel lacto-ganglio type gangliosides with GM2-epitope in bovine brain which react with IgM from a patient of the amyotrophic lateral sclerosis-like disorder.

, 1993
T Nakao, Kazuo Kon, Shoichiro Ando, T. Miyatake, Nobuhiro Yuki, Y.T. Li, Shigeki Furuya, Yoshio Hirabayashi   +7 more
openalex   +1 more source

Analysis of chromosome 5q13 genes in amyotrophic lateral sclerosis: Homozygous naip deletion in a sporadic case [PDF]

, 1996
M. T. Jackson, Karen Morrison, Ammar Al‐Chalabi, Martijn Baldier, Peter Leigh   +4 more
openalex   +1 more source