Results 231 to 240 of about 242,580 (385)

Human Cyclophilins—An Emerging Class of Drug Targets

Medicinal Research Reviews, EarlyView.
ABSTRACT Cyclophilins are a family of enzymes with peptidyl‐prolyl isomerase activity found in all cells of all organisms. To date, 17 cyclophilin isoforms have been identified in the human body, participating in diverse biological processes. Consequently, cyclophilins have emerged as promising targets for drug development to address a wide array of ...
Katarina Jurkova, Hana Navratilova, Kamil Musilek, Ondrej Benek   +3 more
wiley   +1 more source

New Hopes and Challenges for Treatment of Neurodegenerative Disorders: Great Opportunities for Young Neuroscientists

Basic and Clinical Neuroscience, 2013
Mahmoud Kiaei
doaj  

Unveiling the Genetic Association Between Hemoglobin Concentration and Amyotrophic Lateral Sclerosis. [PDF]

Brain Behav
Luo H, Yang Y, Cao X, Deng C, Chen H.
europepmc   +1 more source

Nerve Ultrasound in Patients With Friedreich Ataxia

Muscle &Nerve, EarlyView.
ABSTRACT Introduction/Aims Nerve enlargement has been reported in patients with Friedreich ataxia (FRDA). The underlying cause remains unclear, and both inflammatory processes and dysmyelination have been suggested as potential mechanisms. This study was aimed at assessing nerve morphology with high‐resolution ultrasound, to identify and describe ...
Katharina Kneer, Jan‐Hendrik Stahl, Natalie Winter, Julia Wittlinger, Stephanie Männlin, Toghrul Gasimli, Ludger Schöls, Zofia Fleszar, Stefanie Hayer, Alexander Grimm   +9 more
wiley   +1 more source

ABCA1 acts as a protective modulator in amyotrophic lateral sclerosis. [PDF]

iScience
Li Q, Zhang G, Zheng H, Zhao T, Zhang H, Zhang Y, Luo H, Xu Y.   +7 more
europepmc   +1 more source

The environment and amyotrophic lateral sclerosis: converging clues from epidemiologic studies worldwide.

, 2012
Marco Vinceti
openalex   +1 more source

MRI of Neurogenic Human Motor Units Following Poliomyelitis

Muscle &Nerve, EarlyView.
ABSTRACT Introduction/Aims Surviving motor units in neurogenic diseases demonstrate collateral reinnervation. Scanning electromyography (EMG) reveals normal motor unit corridor length, but with “silent regions,” suggesting that reinnervation does not result in increased motor unit size but may increase motor unit complexity.
Stuart Maitland, Matthew Birkbeck, Ian Schofield, Lawrence Best, James Scott, Andrew Blamire, Roger G. Whittaker   +6 more
wiley   +1 more source

Type I Vs. Type II Cytokine Levels as a Function of SOD1 G93A Mouse Amyotrophic Lateral Sclerosis Disease Progression [PDF]

, 2015
Amilia Jeyachandran, Benjamin Mertens, Eric A. McKissick, Cassie S. Mitchell   +3 more
openalex   +1 more source

Phase 3b Extension Study MT‐1186‐A04 to Evaluate the Continued Efficacy and Safety of Edaravone Oral Suspension for Up to an Additional 48 Weeks in Patients With Amyotrophic Lateral Sclerosis

Muscle &Nerve, EarlyView.
ABSTRACT Introduction/Aims An On/Off dosing regimen of intravenous (IV) edaravone and edaravone oral suspension is currently approved in the US for treatment of amyotrophic lateral sclerosis (ALS). Placebo‐controlled clinical trials showed that IV edaravone slows physical functional decline.
Angela Genge, Jeffrey Rothstein, Shari De Silva, Lorne Zinman, Marvin Chum, Adriano Chiò, Gen Sobue, Masashi Aoki, Hiide Yoshino, Manabu Doyu, Daniel Selness, Vesna Todorovic, Manabu Hirai, Nissim Sasson, Fumihiro Takahashi, Michelle Cecić, Art Wamil, Stephen Apple   +17 more
wiley   +1 more source

Recurarization after sugammadex reversal in a patient with amyotrophic lateral sclerosis: Case report. [PDF]

Medicine (Baltimore)
Wang YW, Zhang Y, Hu X, Li X, Han L, Wang DX, Ding T.   +6 more
europepmc   +1 more source