Discovery and Targeted Proteomic Studies Reveal Striatal Markers Validated for Huntington's Disease
Annals of Clinical and Translational Neurology, EarlyView.ABSTRACT Objective Clinical trials for Huntington's disease (HD) enrolling persons before clinical motor diagnosis (CMD) lack validated biomarkers. This study aimed to conduct an unbiased discovery analysis and a targeted examination of proteomic biomarkers scrutinized by clinical validation. Methods Cerebrospinal fluid was obtained from PREDICT‐HD and
Daniel Chelsky +8 more
wiley +1 more source
ASSOCIATION OF SPORADIC AMYOTROPHIC LATERAL SCLEROSIS WITH HUMAN T LYMPHO-TROPIC VIRUS 1, HUMAN IMMUNODEFICIENCY VIRUS AND HUMAN HERPES VIRUS 8 [PDF]
Acta Medica Iranica, 2006 Amyotrophic lateral sclerosis is a progressive neurodegenerative disease with uncertain etiology. For many years, viruses have been suspected as causative agents. There are conflicting reports about the possible role of viruses such as human herpes virus
A. Tarazi +3 more
doaj +2 more sources
Resilience, anxiety, and depression in amyotrophic lateral sclerosis patients
Psychiatria i Psychologia Kliniczna, 2019 Introduction: Research into amyotrophic lateral sclerosis often focuses on the purely medical aspects of the disease, without paying attention to patient’s experience, suffering and difficulties they face on a daily basis.
Alessia Demuru +3 more
doaj +1 more source
Single copy/knock-in models of ALS SOD1 in C. elegans suggest loss and gain of function have different contributions to cholinergic and glutamatergic neurodegeneration [PDF]
, 2018 Mutations in Cu/Zn superoxide dismutase 1 (SOD1) lead to Amyotrophic Lateral Sclerosis (ALS), a neurodegenerative disease that disproportionately affects glutamatergic and cholinergic motor neurons.
Baskoylu, Saba N +10 more
core +3 more sources
Klotho pathways, myelination disorders, neurodegenerative diseases, and epigenetic drugs [PDF]
, 2020 In this review we outline a rationale for identifying neuroprotectants aimed at inducing endogenous Klotho activity and expression, which is epigenetic action, by definition. Such an approach should promote remyelination and/or stimulate myelin repair by
Chen, Xiaohong +15 more
core +1 more source
Nature Communications, 2019 MR-guided focused ultrasound (MRgFUS) is an emerging technology that can accurately and transiently permeabilize the blood-brain barrier (BBB) for targeted drug delivery to the central nervous system.
A. Abrahão +11 more
semanticscholar +1 more source
Effectiveness and Safety of Nusinersen and Risdiplam in Spinal Muscular Atrophy: A Systematic Review
Annals of Clinical and Translational Neurology, EarlyView.ABSTRACT Objective Spinal Muscular Atrophy (SMA) is a rare genetic disorder marked by progressive muscle weakness and mobility loss. It has a profound physical, emotional and social impact on patients and caregivers, requiring comprehensive medical and supportive care.
Amin Mehrabian +9 more
wiley +1 more source
Peroxynitrite activates the NLRP3 inflammasome cascade in SOD1(G93A) mouse model of amyotrophic lateral sclerosis [PDF]
, 2017 Neuroinflammation, characterized by the appearance of reactive microglial and astroglial cells, is one of the several pathogenic mechanisms of amyotrophic lateral sclerosis (ALS), a fast-progressing and fatal neurodegenerative disease.
Adamo, Sergio +10 more
core +1 more source
Tideglusib, a Non-ATP Competitive Inhibitor of GSK-3β as a Drug Candidate for the Treatment of Amyotrophic Lateral Sclerosis [PDF]
, 2021 Loreto Martínez‐González +6 more
openalex +1 more source
Brain Communications, 2020 Despite wide genetic, environmental and clinical heterogeneity in amyotrophic lateral sclerosis, a rapidly fatal neurodegenerative disease targeting motoneurons, neuroinflammation is a common finding.
Louis-Charles Béland +7 more
semanticscholar +1 more source