Results 71 to 80 of about 235,642 (386)

Molecular Mechanisms of TDP-43 Misfolding and Pathology in Amyotrophic Lateral Sclerosis

Frontiers in Molecular Neuroscience, 2019
TAR DNA binding protein 43 (TDP-43) is a versatile RNA/DNA binding protein involved in RNA-related metabolism. Hyper-phosphorylated and ubiquitinated TDP-43 deposits act as inclusion bodies in the brain and spinal cord of patients with the motor neuron ...
A. Prasad, Vidhya Bharathi, V. Sivalingam, A. Girdhar, B. Patel   +4 more
semanticscholar   +1 more source

Longitudinal biomarkers in amyotrophic lateral sclerosis

Annals of Clinical and Translational Neurology, 2020
To investigate neurodegenerative and inflammatory biomarkers in people with amyotrophic lateral sclerosis (PALS), evaluate their predictive value for ALS progression rates, and assess their utility as pharmacodynamic biomarkers for monitoring treatment ...
F. Huang, Yuda Zhu, Jennifer Hsiao‐Nakamoto, Xinyan Tang, J. Dugas, M. Moscovitch-Lopatin, J. Glass, Robert H. Brown, S. Ladha, D. Lacomis, Jeffrey M Harris, K. Scearce-Levie, Carole Ho, R. Bowser, J. Berry   +14 more
semanticscholar   +1 more source

Screening of the transcriptional regulatory regions of vascular endothelial growth factor receptor 2 (VEGFR2) in amyotrophic lateral sclerosis [PDF]

, 2007
Background Vascular endothelial growth factor (VEGF) has neurotrophic activity which is mediated by its main agonist receptor, VEGFR2. Dysregulation of VEGF causes motor neurone degeneration in a mouse model of amyotrophic lateral sclerosis (ALS), and
Brockington, A., Hartley, J., Nixon, H., Shaw, P.J., Wokke, B.   +4 more
core   +3 more sources

Real-world evidence of riluzole effectiveness in treating amyotrophic lateral sclerosis

Amyotrophic Lateral Sclerosis and Frontotemporal Degeneration, 2020
Objective To compare the effect of riluzole on median survival in population studies of patients with amyotrophic lateral sclerosis (ALS) with that observed in clinical trials.
Jinsy A. Andrews, C. Jackson, T. Heiman-Patterson, P. Bettica, B. Brooks, E. Pioro   +5 more
semanticscholar   +1 more source

Report on the 2nd MObility for Vesicle research in Europe (MOVE) symposium—2024

FEBS Open Bio, EarlyView.
The 2nd MObility for Vesicle research in Europe (MOVE) Symposium in Belgrade brought over 280 attendees from 28 countries to advance extracellular vesicle (EV) research. Featuring keynotes, presentations, and industry sessions, it covered EV biogenesis, biomarkers, therapies, and manufacturing.
Dorival Mendes Rodrigues‐Junior, Michaela Kocholata, Marilena E. Lekka, Olga Janouskova, Moran Yadid, Maja Kosanovic   +5 more
wiley   +1 more source

Promoting Independence Through Effective Interventions For Adults With ALS [PDF]

, 2020
PICO Question What are effective occupational therapy interventions for adults with ALS to improve participation in ADLs/IADLs? Objectives Define amyotrophic lateral sclerosis (ALS) and recognize the prevalence Identify and describe evidence-based ...
Gluchowski, OTS, Renee, Harris, OTS, Hannah, Heineman, OTS, Jaclyn, Kendro, OTS, Kimberly, Malosky, OTS, Heather   +4 more
core   +1 more source

Epidemiology of amyotrophic lateral sclerosis: an update of recent literature

Current Opinion in Neurology, 2019
Purpose of review The cause of amyotrophic lateral sclerosis (ALS) remains unknown for most of the patients with the disease. Epidemiologic studies can help describe disease burden and examine its potential risk factors, providing thereby evidence base ...
Elisa Longinetti, F. Fang
semanticscholar   +1 more source

TDP-43 real-time quaking induced conversion reaction optimization and detection of seeding activity in CSF of amyotrophic lateral sclerosis and frontotemporal dementia patients

Brain Communications, 2020
The pathological deposition of the transactive response DNA-binding protein of 43 kDa occurs in the majority (∼97%) of amyotrophic lateral sclerosis and in around 45% of frontotemporal lobar degeneration cases.
C. Scialò, Thanh Hoa Tran, Giulia Salzano, G. Novi, C. Caponnetto, A. Chiò, A. Calvo, A. Canosa, F. Moda, P. Caroppo, V. Silani, N. Ticozzi, A. Ratti, B. Borroni, L. Benussi, R. Ghidoni, G. Furlanis, P. Manganotti, B. Senigagliesi, P. Parisse, R. Brasselet, E. Buratti, G. Legname   +22 more
semanticscholar   +1 more source

The impact of Hnrnpl deficiency on transcriptional patterns of developing muscle cells

FEBS Open Bio, EarlyView.
We performed nanopore whole‐transcriptome sequencing comparing RNA from Hnrnpl‐knockdown versus control C2C12 myoblasts to investigate the contributions of Hnrnpl to muscle development. Our results indicate that Hnrnpl regulates the expression of genes involved with Notch signaling and skeletal muscle, particularly splicing patterns of specific muscle ...
Hannah R. Littel, Mekala Gunasekaran, Audrey L. Daugherty, Natalya M. Wells, Johnnie Turner, Christine C. Bruels, Christina A. Pacak, Isabelle Draper, Peter B. Kang   +8 more
wiley   +1 more source

OSMR is a potential driver of inflammation in amyotrophic lateral sclerosis

Neural Regeneration Research
Amyotrophic lateral sclerosis is a neurodegenerative disease, and the molecular mechanism underlying its pathology remains poorly understood. However, inflammation is known to play an important role in the development of this condition.
Wenzhi Chen, Shishi Jiang, Shu Li, Cheng Li, Renshi Xu   +4 more
doaj   +1 more source