Results 81 to 90 of about 235,642 (386)

Klotho pathways, myelination disorders, neurodegenerative diseases, and epigenetic drugs [PDF]

, 2020
In this review we outline a rationale for identifying neuroprotectants aimed at inducing endogenous Klotho activity and expression, which is epigenetic action, by definition. Such an approach should promote remyelination and/or stimulate myelin repair by
Chen, Xiaohong, Faller, Douglas V., Glavas, Ioannis P., Harpp, David N., Kanara, Iphigenia, Kodukula, Krishna, Mavrakis, Anastasios N., Moos, Walter H., Pernokas, Julie, Pernokas, Mark, Pinkert, Carl A., Powers, Whitney R., Sampani, Konstantina, Steliou, Kosta, Vavvas, Demetrios G., Zamboni, Robert J.   +15 more
core   +1 more source

Immunity in amyotrophic lateral sclerosis: blurred lines between excessive inflammation and inefficient immune responses

Brain Communications, 2020
Despite wide genetic, environmental and clinical heterogeneity in amyotrophic lateral sclerosis, a rapidly fatal neurodegenerative disease targeting motoneurons, neuroinflammation is a common finding.
Louis-Charles Béland, Andrea Markovinovic, H. Jakovac, F. De Marchi, E. Bilic, L. Mazzini, J. Kriz, Ivana Munitic   +7 more
semanticscholar   +1 more source

Mitochondria‐associated membranes (MAMs): molecular organization, cellular functions, and their role in health and disease

FEBS Open Bio, EarlyView.
Mitochondria‐associated membranes (MAMs) are contact sites between the endoplasmic reticulum and mitochondria that regulate calcium signaling, lipid metabolism, autophagy, and stress responses. This review outlines their molecular organization, roles in cellular homeostasis, and how dysfunction drives neurodegeneration, metabolic disease, cancer, and ...
Viet Bui, Maryline Santerre, Natalia Shcherbik, Bassel E Sawaya   +3 more
wiley   +1 more source

Practice Recommendations for Genetic Testing of Ataxias

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Over the past decade, significant advances in genetic testing for ataxia have improved diagnostic accuracy, informed clinical trial eligibility, guided treatment decisions, and enabled cascade testing of at‐risk relatives. While guidance exists for other neurogenetic conditions, there are no standardized guidelines on genetic ...
Sharan R. Srinivasan, Amy D. Mook, Michelle Rochman, Jin Yun Helen Chen, Weiyi Mu, George R. Wilmot, Liana S. Rosenthal, Wendy R. Uhlmann   +7 more
wiley   +1 more source

Resilience, anxiety, and depression in amyotrophic lateral sclerosis patients

Psychiatria i Psychologia Kliniczna, 2019
Introduction: Research into amyotrophic lateral sclerosis often focuses on the purely medical aspects of the disease, without paying attention to patient’s experience, suffering and difficulties they face on a daily basis.
Alessia Demuru, Claudio Longobardi, Laura Elvira Prino, Michele Settanni   +3 more
doaj   +1 more source

Amyotrophic lateral sclerosis patients show increased peripheral and intrathecal T-cell activation

Brain Communications, 2021
Several studies suggest a role for the peripheral immune system in the pathophysiology of amyotrophic lateral sclerosis. However, comprehensive studies investigating the intrathecal immune system in amyotrophic lateral sclerosis are rare.
L. Rolfes, A. Schulte-Mecklenbeck, S. Schreiber, S. Vielhaber, M. Herty, Anika Marten, S. Pfeuffer, T. Ruck, H. Wiendl, C. Gross, S. Meuth, M. Boentert, M. Pawlitzki   +12 more
semanticscholar   +1 more source

Nerve Excitability in Asymptomatic Carriers and Amyotrophic Lateral Sclerosis Patients With C9orf72

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective We investigated the effects of C9orf72 mutation carriership on peripheral nerve excitability in asymptomatic individuals from families with a history of C9orf72 amyotrophic lateral sclerosis (ALS) and patients. Methods We included 47 asymptomatic individuals from families with a history of C9orf72 ALS, of whom 23 were carriers (C9 ...
Diederik J. L. Stikvoort García, H. Stephan Goedee, Leonard H. van den Berg, Boudewijn T. H. M. Sleutjes   +3 more
wiley   +1 more source

ASSOCIATION OF SPORADIC AMYOTROPHIC LATERAL SCLEROSIS WITH HUMAN T LYMPHO-TROPIC VIRUS 1, HUMAN IMMUNODEFICIENCY VIRUS AND HUMAN HERPES VIRUS 8 [PDF]

Acta Medica Iranica, 2006
Amyotrophic lateral sclerosis is a progressive neurodegenerative disease with uncertain etiology. For many years, viruses have been suspected as causative agents. There are conflicting reports about the possible role of viruses such as human herpes virus
A. Tarazi, S. Nafissi, A. A. Amirzargar, P. Ayatollahi A. Soltanzadeh   +3 more
doaj   +2 more sources

Cerebellar pathology in motor neuron disease: neuroplasticity and neurodegeneration

Neural Regeneration Research, 2022
Amyotrophic lateral sclerosis is a relentlessly progressive multi-system condition. The clinical picture is dominated by upper and lower motor neuron degeneration, but extra-motor pathology is increasingly recognized, including cerebellar pathology. Post-
Rangariroyashe H Chipika, Grainne Mulkerrin, Pierre-François Pradat, Aizuri Murad, Fabrice Ango, Cédric Raoul, Peter Bede   +6 more
doaj   +1 more source

First-in-human trial of blood–brain barrier opening in amyotrophic lateral sclerosis using MR-guided focused ultrasound

Nature Communications, 2019
MR-guided focused ultrasound (MRgFUS) is an emerging technology that can accurately and transiently permeabilize the blood-brain barrier (BBB) for targeted drug delivery to the central nervous system.
A. Abrahão, Ying Meng, Maheleth Llinas, Yuexi Huang, C. Hamani, T. Mainprize, I. Aubert, C. Heyn, S. Black, K. Hynynen, N. Lipsman, L. Zinman   +11 more
semanticscholar   +1 more source