Results 91 to 100 of about 341,458 (322)

An engineered non-oxidative glycolytic bypass based on Calvin-cycle enzymes enables anaerobic co-fermentation of glucose and sorbitol by Saccharomyces cerevisiae

Biotechnology for Biofuels and Bioproducts, 2022
Background Saccharomyces cerevisiae is intensively used for industrial ethanol production. Its native fermentation pathway enables a maximum product yield of 2 mol of ethanol per mole of glucose. Based on conservation laws, supply of additional electrons
Aafke C. A. van Aalst, Robert Mans, Jack T. Pronk   +2 more
doaj   +1 more source

WTAP Mediated m6A Modification Stabilizes PDIA3P1 and Promotes Tumor Progression Driven by Histone Lactylation in Esophageal Squamous Cell Carcinoma

Advanced Science, EarlyView.
This study reveals a new mechanism by which PDIA3P1 regulates the progression of esophageal squamous cell carcinoma (ESCC). PDIA3P1 upregulates the expression of GLUT1 and HK2, promoting glycolysis and lactate production. Lactate upregulates the lactylation level of histone H4K8 and activates the transcription of target gene BMP7, ultimately ...
Tao Huang, Qi You, Jiawei Liu, Xuguang Shen, Dengjun Huang, Xinlu Tao, Zhijie He, Chengwei Wu, Xinran Xi, Shouqiang Yu, Feng Liu, Zhihao Wu, Wenjun Mao, Shaojin Zhu   +13 more
wiley   +1 more source

The Prolyl Hydroxylase Domain 2 (PHD2) Deficiency Enhances Maximal Exercise Capacity [PDF]

운동과학
PURPOSE Hypoxic training is beneficial for improving endurance performance. Hypoxia-inducible factor (HIF) is a key transcription factor that regulates the hypoxic-responsive pathway. Stabilization of HIF by inactivating prolyl hydroxylase domain protein
Junchul Shin
doaj   +1 more source

Glycolysis-related gene expression profiling serves as a novel prognosis risk predictor for human hepatocellular carcinoma

Scientific Reports, 2021
Metabolic pattern reconstruction is an important factor in tumor progression. Metabolism of tumor cells is characterized by abnormal increase in anaerobic glycolysis, regardless of high oxygen concentration, resulting in a significant accumulation of ...
Lingyu Zhang, Yu Li, Yibei Dai, Danhua Wang, Xuchu Wang, Ying Cao, Weiwei Liu, Zhihua Tao   +7 more
doaj   +1 more source

Model evaluation for glycolytic oscillations in yeast biotransformations of xenobiotics [PDF]

, 2004
Anaerobic glycolysis in yeast perturbed by the reduction of xenobiotic ketones is studied numerically in two models which possess the same topology but different levels of complexity. By comparing both models' predictions for concentrations and fluxes as
Beaudoin, Berridge, Bertau, Bertau, Bertau, Brusch, Cabon, Calabrese, Dahl, Danø, Davoli, Doedel, Fall, François, G. Cuniberti, Gonzalez, Guet, Hauser, Heinrich, Hynne, Kaplan, Kar, Kometani, Kummer, L. Brusch, Lazar, Lee, M. Bertau, Mendes, Miklos, Mochizuki, North, Oliver, Olsen, Ostergaard, Reijenga, Richter, Rizzi, Schuster, Sonnleitner, Strogatz, Sybesma, Teusink, Tyson, Voit, von Dassow, Westerhoff, Wolf, Wolf   +48 more
core   +2 more sources

EGFR‐TKIs Induced DPP4 Drives Metabolic Reprogramming of Persister Cells in Lung Cancer

Advanced Science, EarlyView.
Drug‐tolerant persister (DTP) cells emerge early during EGFR‐TKI treatment, preceding the development of acquired resistance. Elevated DPP4 in DTP cells drives metabolic reprogramming and antioxidant adaptation, promoting cell survival under drug pressure.
Yuanzhou Zhang, Xiaojun Zhang, Xupeng Yang, Xingshi Chen, Yuehong Wang, Jingying Hu, Rui Liu, Xiaoying Luo   +7 more
wiley   +1 more source

Phosphoproteomic Analysis of Xenopus laevis Reveals Expression and Phosphorylation of Hypoxia-Inducible PFKFB3 during Dehydration

iScience, 2020
Summary: Xenopus laevis tolerate dehydration when their environments evaporate during summer months. Protein phosphorylation has previously shown to regulate important adaptations in X. laevis, including the transition to anaerobic metabolism.
Liam J. Hawkins, Xiaoshuang Wang, Xiaomin Xue, Hui Wang, Kenneth B. Storey   +4 more
doaj  

Inhibition of eIF5A hypusination reprogrammes metabolism and glucose handling in mouse kidney

Cell Death and Disease, 2021
Inhibition of the eukaryotic initiation factor 5A activation by the spermidine analogue GC7 has been shown to protect proximal cells and whole kidneys against an acute episode of ischaemia.
Marc Cougnon, Romain Carcy, Nicolas Melis, Isabelle Rubera, Christophe Duranton, Karine Dumas, Jean-François Tanti, Catherine Pons, Nicolas Soubeiran, Marina Shkreli, Thierry Hauet, Luc Pellerin, Sébastien Giraud, Nicolas Blondeau, Michel Tauc, Didier F. Pisani   +15 more
doaj   +1 more source

Is Lactate an Oncometabolite? Evidence Supporting a Role for Lactate in the Regulation of Transcriptional Activity of Cancer-Related Genes in MCF7 Breast Cancer Cells. [PDF]

, 2019
Lactate is a ubiquitous molecule in cancer. In this exploratory study, our aim was to test the hypothesis that lactate could function as an oncometabolite by evaluating whether lactate exposure modifies the expression of oncogenes, or genes encoding ...
Brooks, George A, Julian, Colleen G, Martinez, Janel, Matarazzo, Christopher, San-Millán, Iñigo   +4 more
core   +1 more source

Aberrant Glycosylation of IgG in Children With Active Lupus Nephritis Alters Podocyte Metabolism and Causes Podocyte Injury

Arthritis &Rheumatology, EarlyView.
Objective Podocytes are integral to the maintenance of the glomerular filtration barrier. Their injury results in proteinuria and disease progression in lupus nephritis (LN). Aberrant IgG glycosylation drives podocyte injury in LN and leads to cytoskeletal rearrangement, motility changes, and decreased nephrin production.
Rhea Bhargava, Rohit Upadhyay, Cong Zhao, Prasad Katakam, Scott Wenderfer, Jing Chen, Hua He, Richard Cummings, Maria G. Tsokos, George C. Tsokos   +9 more
wiley   +1 more source