Results 71 to 80 of about 314,893 (262)

Modelling energy metabolism dysregulations in neuromuscular diseases: A case study of calpainopathy

Heliyon
Biological modelling helps understanding complex processes, like energy metabolism, by predicting pathway compensations and equilibrium under given conditions.
Camille Siharath, Olivier Biondi, Sabine Peres   +2 more
doaj   +1 more source

Pyruvate Kinase M2 and Cancer: The Role of PKM2 in Promoting Tumorigenesis

Frontiers in Oncology, 2020
Pyruvate kinase plays a pivotal role in regulating cell metabolism. The final and rate-limiting step of glycolysis is the conversion of Phosphoenolpyruvate (PEP) to Pyruvate, which is catalyzed by Pyruvate Kinase. There are four isomeric, tissue-specific
Kulsoom Zahra, Tulika Dey, Ashish, Surendra Pratap Mishra, Uma Pandey   +4 more
doaj   +1 more source

Reduction of Intestinal Redox Potential by Coated Ferulic Acid Accelerates Microbial Restoration and Restricts Enterotoxigenic Escherichia coli Colonization in Weaned Piglets

Animal Research and One Health, EarlyView.
Schematic illustration showing the distinct microbe–host crosstalk patterns shaped by intestinal redox potential. The orange‐blue gradient indicated the redox potential transition from a low to a high potential microenvironment. Under low redox potential, Lactobacillus, Ligilactobacillus, Lachnospira, Roseburia, and Lachnoclostridium promoted ...
Ni Feng, Xin Guo, Changsong Fu, Weiyun Zhu, Yong Su   +4 more
wiley   +1 more source

Mechanisms of adaptation to intensive loads of 400 meters’ hurdles runners at stage of initial basic training

Physical Education of Students, 2015
Purpose: is study of adaptation mechanisms of 400 meter’ hurdles-runners to intensive physical loads. Material: in the research 13 - 400 meters’ hurdles-runners and 13 - 400 meters’ runners participated.
A.S. Rovniy, V.M. Lastochkin
doaj   +1 more source

An engineered non-oxidative glycolytic bypass based on Calvin-cycle enzymes enables anaerobic co-fermentation of glucose and sorbitol by Saccharomyces cerevisiae

Biotechnology for Biofuels and Bioproducts, 2022
Background Saccharomyces cerevisiae is intensively used for industrial ethanol production. Its native fermentation pathway enables a maximum product yield of 2 mol of ethanol per mole of glucose. Based on conservation laws, supply of additional electrons
Aafke C. A. van Aalst, Robert Mans, Jack T. Pronk   +2 more
doaj   +1 more source

Neurovascular coupling in bone regeneration: Mechanisms, advanced biomaterials and challenges

BMEMat, EarlyView.
This figure illustrates various material strategies for neurovascularized bone regeneration, including electroactive scaffolds, ion‐loaded materials, drug delivery systems, surface modifications, cells/cell products, growth factors, and peptides. These approaches aim to synergistically promote the regeneration of neural, vascular, and bone tissues ...
Yixin Ma, Nan Jiang, Liyuan Chen, He Zhang, Xinjia Cai, Karan Gulati, Danqing He, Zhigang Cai, Yan Liu   +8 more
wiley   +1 more source

Transcriptomic signature of Leishmania infected mice macrophages: a metabolic point of view.

PLoS Neglected Tropical Diseases, 2012
We analyzed the transcriptional signatures of mouse bone marrow-derived macrophages at different times after infection with promastigotes of the protozoan parasite Leishmania major.
Imen Rabhi, Sameh Rabhi, Rym Ben-Othman, Axel Rasche, Adriani Daskalaki, Bernadette Trentin, David Piquemal, Béatrice Regnault, Albert Descoteaux, Lamia Guizani-Tabbane, Sysco Consortium   +10 more
doaj   +1 more source

ANAEROBIC GLYCOLYSIS IN AMPHIBIAN DEVELOPMENT

The Biological Bulletin, 1962
1. R. pipiens embryos, and gastrula-arrested hybrid embryos obtained by fertilizing R. pipiens eggs with R. sylvatica sperm, begin to produce lactic acid, without initial lag, as soon as they are deprived of oxygen.2. Provided that they are younger than about 72 hours (18° C.), embryos of both types are able to sustain the initial rate of glycolysis ...
openaire   +2 more sources

Beyond antimicrobials: Ecological nano‐strategies for rebalancing dysbiotic oral microbial homeostasis

BMEMat, EarlyView.
Oral microbial homeostasis, a dynamic host‐microbe balance, is vital in infectious diseases. Conventional antibiotics often disrupt this homeostasis, spurring interest in nanomaterials for oral microbial homeostasis rebalancing. This review outlines nanomaterial strategies across three ecological levels (population/community, ecosystem, and cross ...
Chen Hu, Aohan Luan, Yujun Yang, Linlin Wang, Huilin Wang, Ning Wang, Guixin He, Yajie Yang, Rabiya Noor, Jawad Hussain, Longquan Shao   +10 more
wiley   +1 more source

Thiamine Diphosphate‐Dependent Biocatalysis in the 21st Century

Chemistry – A European Journal, EarlyView.
This account summarizes the major discoveries and recent advances, highlighting the biocatalytic abilities, mechanistic studies, and feature‐based classification that are shaping emerging perspectives on thiamine diphosphate (ThDP)‐dependent catalysis.
Lucrezia Lanza, Daniela Bjarnesen, Michael Müller   +2 more
wiley   +1 more source