Results 91 to 100 of about 41,612 (257)

Pasteur effect in leukocyte energy metabolism of patients with mild, moderate, and severe COVID-19

Türk Biyokimya Dergisi
The Pasteur effect in cellular energy metabolism is defined as the switch to anaerobic glycolysis due to alterations in ambient oxygen concentration or inhibition of the electron transport chain (ETC) and oxidative phosphorylation.
Ortatatli Mesut, Sengul Goksemin Fatma, Fatsa Tugba, Sertoglu Erdim, Boyunaga Hakan, Kenar Levent   +5 more
doaj   +1 more source

High‐Altitude Adaptation of Frogs (Case Study: Nanorana parkeri): From Physiological Phenotypes to AltitudeOmics

Integrative Zoology, EarlyView.
High altitudes are challenging for the animals that inhabit these environments. The Xizang plateau frog (Nanorana parkeri) survives in high‐altitude environments through a synergistic strategy of metabolic remodeling and protein expression adjustment to optimize energy efficiency and enhance cellular protection.
Xuejing Zhang, Yonggang Niu, Shengkang Men, Yanghuilin Zhang, Xiaolong Tang, Kenneth B. Storey, Qiang Chen   +6 more
wiley   +1 more source

Notch signaling regulates metabolic heterogeneity in glioblastoma stem cells [PDF]

, 2017
Glioblastoma (GBM) stem cells (GSCs) reside in both hypoxic and vascular microenvironments within tumors. The molecular mechanisms that allow GSCs to occupy such contrasting niches are not understood.
Galifianakis, Nataliya, Luis Chiriboga, Zagzag, David, Adriana Heguy, Dolgalev, Igor, Khahera, Anadjeet, Matija Snuderl, Jonathan Serrano, Serrano, Jonathan, Anadjeet Khahera, Sheng Si, Illa-Bochaca, Irineu, Placantonakis, Dimitris G, Nataliya Galifianakis, Frenster, Joshua D, Sen, Rajeev, Ortenzi, Valerio, Chesler, Mitch, Joshua D. Frenster, Valerio Ortenzi, Snuderl, Matija, Heguy, Adriana, Irineu Illa-Bochaca, Mary Helen Barcellos-Hoff, Chiriboga, Luis, Barcellos-Hoff, Mary Helen, Si, Sheng, Igor Dolgalev, Doyle, Werner, Bayin, N Sumru, Golfinos, John G, Modrek, Aram S, Tsirigos, Aristotelis, Dimitris G. Placantonakis, David Zagzag, John G. Golfinos, Rajeev Sen, N. Sumru Bayin, Aram S. Modrek, Aristotelis Tsirigos, Mitch Chesler, Werner Doyle   +41 more
core   +1 more source

Kaempferol Protects Intestinal Health in Chinese Forest Musk Deer Possibly by Regulating Intestinal Microbiota and Inhibiting the NF‐κB/NLRP3 Signaling Pathway

Integrative Zoology, EarlyView.
Kaempferol modulates the tryptophan metabolism pathway by increasing the abundances of Christensenellaceae R7 group, Bacteroides, and Blautia and reducing that of Rikenellaceae RC9 gut group, thereby significantly increasing the levels of ILA and IAA. This process inhibits the activation of NF‐κB/NLRP3 signaling pathway, reduces pro‐inflammatory factor
Xiangyu Liu, Zhanjun Ren, Xiuzhu Sun, Shuhui Wang   +3 more
wiley   +1 more source

Factors affecting the anaerobic glycolysis of brain tissue and the effects of sodium and potassium on brain metabolism.

, 1956
The experiments to be presented consist of an attempt to extend the observations of Dickens and Greville on the effects of anoxia and lack of substrate on the subsequent carbohydrate metabolism of brain tissue.
Rosenfeld, Michael. W.
core  

Iron Physiology and Its Impact on Atopic Diseases: An EAACI Taskforce Report

Allergy, EarlyView.
ABSTRACT Iron is essential for oxygen transport, energy metabolism, and immune regulation. Yet iron deficiency is the most common micronutrient disorder across all age groups, affecting nearly one quarter of the global population. Iron deficiency triggers nutritional immunity, a host defense mechanism that withholds and redistributes iron, contributing
Franziska Roth‐Walter, Ioana Agache, Beatriz Cabanillas, Roberto Berni Canani, Pasquale Comberiati, Holger Garn, Cristina Gomez‐Casado, Karin Hufnagl, Ekaterina Khaleva, Gregorio P. Milani, Daniel Munblit, Nikolaos Douladiris, Liam O'Mahony, Frank Redegeld, Carmen Riggioni, Peter K. Smith, Betty van Esch, Emilia Vassilopoulou, Carina Venter, Diego G. Peroni   +19 more
wiley   +1 more source

NAD Metabolism in Cancer Therapeutics

Frontiers in Oncology, 2018
Cancer cells have a unique energy metabolism for sustaining rapid proliferation. The preference for anaerobic glycolysis under normal oxygen conditions is a unique trait of cancer metabolism and is designated as the Warburg effect.
Keisuke Yaku, Keisuke Okabe, Keisuke Okabe, Keisuke Hikosaka, Takashi Nakagawa, Takashi Nakagawa   +5 more
doaj   +1 more source

Dendritic Cell α‐Ketoglutarate Regulates Tfh Polarization in Allergy

Allergy, EarlyView.
Allergen induces a dendritic cell metabolism shift toward glutaminolysis with α‐ketoglutarate as a regulator of Tfh subset polarization. Glutaminolysis is required for DC allergen uptake, co‐stimulatory molecule expression, and CLR expression. Modulation of glutaminolysis, JmjD3 histone demethylation, or HIF‐1α degradation alters Tfh polarization and ...
Anuj Tharakan, Xufeng Qu, Carmen Camarena, Araba Abaidoo‐Myles, Parth Naik, Jeremy Allegood, Ankit Kumar, Mihir Pokhriyal, Joseph C. Lownik, Matthew P. Zellner, Grayson W. Way, Jinze Liu, Lauren Ashley Cowart, Stephanie C. Eisenbarth, Joseph W. Landry, Daniel H. Conrad, Rebecca K. Martin   +16 more
wiley   +1 more source

Lactate activates HIF-1 in oxidative but not in Warburg-phenotype human tumor cells.

PLoS ONE, 2012
Cancer can be envisioned as a metabolic disease driven by pressure selection and intercellular cooperativeness. Together with anaerobic glycolysis, the Warburg effect, formally corresponding to uncoupling glycolysis from oxidative phosphorylation ...
Christophe J De Saedeleer, Tamara Copetti, Paolo E Porporato, Julien Verrax, Olivier Feron, Pierre Sonveaux   +5 more
doaj   +1 more source

A Four‐Week Treatment With Dapagliflozin Is Associated With a Reduction in Insulin‐Stimulated Renal Cortical Glucose Uptake: A Post Hoc Analysis From a Pilot Study

Diabetes, Obesity and Metabolism, EarlyView.
ABSTRACT Introduction and Objective Treatment with sodium‐glucose cotransporter‐2 inhibitors (SGLT‐2i) reduces the risk of both cardiovascular and renal outcomes in type 2 diabetes (T2D). The specific mechanism by which this happens has not yet been clarified.
Shawn Gugliandolo, Cassandra Morciano, Andrea Guarneri, Gian Pio Sorice, Marta Giaccari, Luigi Cappannoli, Umberto Capece, Amelia Splendore, Adriana Avolio, Lorenzo Diego Greco, Patricia Iozzo, Rossana Moroni, Alfredo Pontecorvi, Maria Lucia Calcagni, Francesco Burzotta, Domenico D'Amario, Filippo Crea, Lucia Leccisotti, Francesca Cinti   +18 more
wiley   +1 more source