Results 81 to 90 of about 41,612 (257)

Enhancers regulate anaerobic glycolysis in old cardiomyocytes

, 2019
Heart failure is a typical age-associated pathology with high rates of mortality and morbidity. Age-related cardiac malfunctioning is multifactorial and cardiac remodelling contributes to this.
Pierluigi Carullo, Nadia Corrado, Papait Roberto, Gianluigi Condorelli, Christina Pagiatakis, Simone Serio   +5 more
core  

Aliphatic Poly(Carbonate)s with Acid Responsive Release Mechanisms for Micellar Anti‐Tumor Drug Delivery

Macromolecular Rapid Communications, EarlyView.
Micellar systems based on biodegradable aliphatic polycarbonates and acid‐responsive triggers enhance drug solubility, stability, and tumor‐selective release. This review covers micelles with acid‐cleavable drug linkages and those that disassemble via acid‐sensitive functionalities.
Adrian V. Hauck, Lutz Nuhn
wiley   +1 more source

LKB1 Loss Sensitizes Lung Tumor Spheres to Mitomet‐Induced Ferroptosis, and These Effects are Enhanced by mTOR Inhibition

Molecular Carcinogenesis, EarlyView.
ABSTRACT Owing to their robust antioxidant defense mechanisms, cancer stem‐like cells (CSCs) maintain a low level of oxidative stress, which is crucial for preserving stemness and pluripotency. Therefore, agents that either directly generate reactive oxygen species (ROS) or inhibit the antioxidant defense systems can selectively induce oxidative cell ...
Xueqing Liang, Ali Nakhi, Peter I. Dosa, Gunda I. Georg, Fekadu Kassie   +4 more
wiley   +1 more source

ANAEROBIC GLYCOLYSIS IN AMPHIBIAN DEVELOPMENT. HOMOGENATES

The Biological Bulletin, 1964
1. Freshly prepared homogenates of R. pipiens embryos contain considerable amounts of lactic acid, aerobically produced from an unknown source. The amount present is an increasing function of the age of the embryos from which the homogenates are made.2. In the presence of suitable exogenous substrates, anaerobic homogenates of R.
Gregg, John R, Macisaac, Jane J, Parker, Mary Ann   +2 more
openaire   +2 more sources

Biosurfactant production by Pseudomonas aeruginosa isolated from mining waste: From genomic analysis to development of a polymeric composite for removal of hexavalent chromium

Polymer International, EarlyView.
Biosurfactant was produced by Pseudomonas aeruginosa using andiroba waste from Amazonia. A biosurfactant–alginate composite (Alg/BioS) was successfully synthesized via ionotropic gelation, and achieved up to 70% Cr6+ removal from water. Abstract Environmental contamination by heavy metals represents a significant challenge due to their persistence in ...
Paulo Diniz Austriaco, Emilly Cruz da Silva, Glenda Sores Gomes, Joane Almeida Alves, Amanda Vidal, Leandro Argolo, Rafaela Ribeiro, Luciana Souza, José Augusto Pires Bitencourt, Leonardo Brasil Felipe, Leonie Asfora Sarubbo, Sidnei Cerqueira dos Santos   +11 more
wiley   +1 more source

Thermogenic protein UCP1 and UCP3 expression in non-small cell lung cancer: relation with glycolysis and anaerobic metabolism

Cancer Biology & Medicine, 2017
Uncoupling protein 1 (UCP1) is a proton transporter/channel residing on the inner mitochondrial membrane and is involved in cellular heat production. Using immunohistochemistry, we investigated the expression of UCP1 and UCP3 in a series of 98 patients ...
Alexandra Giatromanolaki, Konstantina Balaska, Dimitra Kalamida, Christos Kakouratos, Efthimios Sivridis, Michael I. Koukourakis   +5 more
doaj   +1 more source

Modeling the lung‒brain axis in critical illness: Multifactorial crosstalk through organoids and organ‐on‐a‐chip system

VIEW, EarlyView.
Patients in intensive care units often experience lung injuries, complicated by brain problems. Advanced laboratory tools, organoids, and organs‐on‐chips facilitated the study of multiorgan interactions, help us understand the communication between the lungs and brain.
Wanyi Zhang, Ting Wang, Mengying Yao, Longxiang Su, Lixin Xie, Pan Pan   +5 more
wiley   +1 more source

Abstract 4663: Markers of anaerobic glycolysis as predictive factor in neoadjuvant chemoradiotherapy of rectal cancer

, 2010
Background: Growing tumors adapt to a hypoxic environment and increase anaerobic glycolysis. This metabolic switch is related to resistance of radiotherapy and chemotherapy.
Hyung Jin Kim, Hyun Min Cho, Sook Hee Hong, Ji Han Jung, Hoon-Kyo Kim, Kang-Moon Lee, ByoungYong Shim, Sung Whan Kim, Der Sheng Sun   +8 more
core   +1 more source

Not Available

, 2021
Not AvailableThe ongoing pandemic of novel coronavirus disease (COVID-19) has killed millions across the globe. This paper hypothesizes anaerobic glycolysis and dehydrogenase enzymes as the focal points of SARS-CoV-2 pathogenesis that ensure virus ...
Sanjib Kumar Manna
core   +1 more source

Comparison of Three Sympatric Desert Lizards: Digestive Tract Structure, Digestive Enzyme Activities, Gut Microbiota, and Metabolites

Integrative Zoology, EarlyView.
We performed 16S rDNA sequencing and metabolite profiling for three sympatric lizard species—Teratoscincus roborowskii, Phrynocephalus axillaris, and Eremias roborowskii—and compared their goblet cell and enzyme activities in the digestive tract. Our study suggests that the dietary niche may promote divergence or convergence of microbiota across host ...
Yi Yang, Ziyi Wang, Ruichen Wu
wiley   +1 more source