Results 51 to 60 of about 261,537 (268)

Pyruvate Kinase M2 and Cancer: The Role of PKM2 in Promoting Tumorigenesis

Frontiers in Oncology, 2020
Pyruvate kinase plays a pivotal role in regulating cell metabolism. The final and rate-limiting step of glycolysis is the conversion of Phosphoenolpyruvate (PEP) to Pyruvate, which is catalyzed by Pyruvate Kinase. There are four isomeric, tissue-specific
Kulsoom Zahra, Tulika Dey, Ashish, Surendra Pratap Mishra, Uma Pandey   +4 more
doaj   +1 more source

The role and mechanism of histone lactylation in health and diseases

Frontiers in Genetics, 2022
Whether under anaerobic or aerobic conditions, glycolysis results in production of lactate. Increasing evidence suggests that lactate serves as a multifunctional signaling molecule that develops non-metabolic activities in addition to serving as a key ...
Yumei Xie, Hongxia Hu, Maoting Liu, Tingting Zhou, Xi Cheng, Wei Huang, Ling Cao   +6 more
doaj   +1 more source

A Pathology‐Instructed Theranostic Platform with Mechanoadaptive and ROS‐Powered Nanobreathing Functions for Precision Myocardial Repair

Advanced Science, EarlyView.
We developed a pH responsive theranostic serum albumin hydrogel named BST, functionalized with MRI and CT probes and loaded with mitochondria targeted CAT‐SOD nanogels, that rapidly self repairs and mechanically stabilizes the infarcted myocardium, releases therapeutic nanogels and albumin under hypoxia induced acidosis to clear mitochondrial ROS ...
Zheng Luo, Cui Yang, Liuzhou Mao, Panqin Ma, Chiyu Jia, Karen Yuanting Tang, Xian Jun Loh, Yun‐Long Wu   +7 more
wiley   +1 more source

Peroxisomal Fatty Acid Oxidation and Glycolysis Are Triggered in Mouse Models of Lesional Atopic Dermatitis

JID Innovations, 2021
Alterations of the lipid profile of the stratum corneum have an important role in the pathogenesis of atopic dermatitis (AD) because they contribute to epidermal barrier impairment. However, they have not previously been envisioned as a cellular response
Petra Pavel, Géraldine Leman, Martin Hermann, Christian Ploner, Thomas O. Eichmann, Deborah Minzaghi, Franz P.W. Radner, Barbara Del Frari, Robert Gruber, Sandrine Dubrac   +9 more
doaj   +1 more source

Effect of barbiturates on anaerobic glycolysis

Folia Pharmacologica Japonica, 1970
As a basis for understanding the mechanism of action of barbiturates, a study of their inhibitory properties on anaerobic glycolysis was undertaken. In starved rats received single intraperitoneal injections of 50 mg/kg pentobarbital or of 100 mg/kg phenobarbital, there was observed a significant decrease in the blood levels of pyruvate and lactate at ...
openaire   +3 more sources

TRAF6 Lactylation in Glycolytic Macrophages Drives NF‐κB Signaling and M1 Polarization During Orthodontic Tooth Movement

Advanced Science, EarlyView.
Schematic diagram showing compressive stress triggers glycolytic reprogramming and lactate accumulation in macrophages. Lactate mediates TRAF6 lactylation at K171/K180 dual sites, which enhances its K63‐linked ubiquitination to activate the NF‑κB pathway and promote M1 polarization. This cascade drives orthodontic tooth movement (OTM) and alveolar bone
Xinyi He, Guodong Zhao, Yun Hu, Wenya Bai, Hao Tan, Shuai Yuan, Sihan Yang, Ye Zhu, Xiaohui Xu, Leilei Zheng   +9 more
wiley   +1 more source

Effect of ultrasonic, thermal and ozone pre-treatments on waste activated sludge solubilisation and anaerobic biodegradability [PDF]

, 2006
In order to enhance the efficiency of anaerobic digestion, the effects of ultrasounds, ozonation and thermal pre-treatment have been studied on waste activated sludge.
Xin Tian, Darmency, Henri, Bougrier, Claire, Delgenès, Jean-Philippe, Carrère, Hélène, Albasi, Claire, Tian, Xin, Henri Darmency   +7 more
core   +1 more source

Bifidobacterium- and Escherichia-dominant ecological guilds shape altered microbial metabolic capacity of the gut microbiome in tuberculosis patients

Frontiers in Cellular and Infection Microbiology
IntroductionThe gut microbial community plays a key role in maintaining the host immune homeostasis. However, current analytical approaches analyze individual taxa rather than gut communities, thereby missing community-level functions performed by units,
Milyausha Yunusbaeva, Dina Sabirova, Liliya Borodina, Karina Khasanova, Aliya Yunusbayeva, Aliya Yunusbayeva, Radick Altinbaev, Ildar Ganiev, Bayazit Yunusbayev, Bayazit Yunusbayev   +9 more
doaj   +1 more source

Mechanisms of adaptation to intensive loads of 400 meters’ hurdles runners at stage of initial basic training

Physical Education of Students, 2015
Purpose: is study of adaptation mechanisms of 400 meter’ hurdles-runners to intensive physical loads. Material: in the research 13 - 400 meters’ hurdles-runners and 13 - 400 meters’ runners participated.
A.S. Rovniy, V.M. Lastochkin
doaj   +1 more source

Warburg Effect, Glutamine, Succinate, Alanine, When Oxygen Matters

Biology, 2021
Cellular bioenergetics requires an intense ATP turnover that is increased further by hypermetabolic states caused by cancer growth or inflammation. Both are associated with metabolic alterations and, notably, enhancement of the Warburg effect (also known
Frédéric Bouillaud, Noureddine Hammad, Laurent Schwartz   +2 more
doaj   +1 more source