Results 161 to 170 of about 350,338 (294)

Human hypoxia models in aerospace medicine: Potential applications for human pharmacological research

British Journal of Clinical Pharmacology, EarlyView.
Aerospace medicine required controlled terrestrial models to investigate influences of altered atmosphere conditions, such as hypoxia, on human health and performance. These models could potentially be expanded to encompass disease conditions or treatment targets regulated through hypoxia or hypercapnia.
Titiaan E. Post, Cayla Denney, Adam Cohen, Jens Jordan, Ulrich Limper   +4 more
wiley   +1 more source

Glucose deprivation activates a metabolic and signaling amplification loop leading to cell death. [PDF]

, 2012
The altered metabolism of cancer can render cells dependent on the availability of metabolic substrates for viability. Investigating the signaling mechanisms underlying cell death in cells dependent upon glucose for survival, we demonstrate that glucose ...
Graeber, Thomas G, Graham, Nicholas A, Kohli, Bitika, Komisopoulou, Evangelia, Lo, Roger S, Mellinghoff, Ingo K, Mischel, Paul S, Ribas, Antoni, Tahmasian, Martik, Teitell, Michael A, Vivanco, Igor, Wu, Hong, Zhu, Maggie   +12 more
core  

The impact of Foxp3+ regulatory T‐cells on CD8+ T‐cell dysfunction in tumour microenvironments and responses to immune checkpoint inhibitors

British Journal of Pharmacology, EarlyView.
Immune checkpoint inhibitors (ICIs) have been a breakthrough in cancer therapy, inducing durable remissions in responding patients. However, they are associated with variable outcomes, spanning from disease hyperprogression to complete responses with the onset of immune‐related adverse events.
Mikhaël Attias, Ciriaco A. Piccirillo
wiley   +1 more source

Katarak Diabetes

JKS (Jurnal Kedokteran Syiah Kuala), 2011
Abstrak. Sebagian besar  (78%) pemecahan glukosa didalam lensa melalui jalur glikolisis anaerobik, 14% melalui jalur pentosa fosfat, sekitar 5% melalui jalur poliol.
Arti Lukitasari
doaj  

Insulin-like growth factor (IGF-I) induces myotube hypertrophy associated with an increase in anaerobic glycolysis in a clonal skeletal-muscle cell model [PDF]

, 1999
Christopher SEMSARIAN, Pramod SUTRAVE, David R. RICHMOND, Robert M. GRAHAM   +3 more
openalex   +1 more source

Paradoxical mitochondrial effects of nitric oxide synthase inhibition following oxygen–glucose deprivation–reoxygenation (OGD/R) in endothelial cells and neurons

British Journal of Pharmacology, EarlyView.
Background and Purpose Current dogma in stroke is that neuronal nitric oxide synthase (NOS1) exacerbates ischaemic brain injury, while endothelial nitric oxide synthase (NOS3) is protective. However, oxidative stress from ischaemia–reperfusion and oxygen–glucose deprivation‐reoxygenation (OGD/R) is known to uncouple NOS, leading to increased production
Venkata N. Sure, Siva S. V. P. Sakamuri, Lokanatha Orgunati, Raed Ageeli, Walter L. Murfee, Prasad V. G. Katakam   +5 more
wiley   +1 more source

Comparative metabolomic and transcriptomic analysis of 2D and 3D mesenchymal stem cell cultures for improved therapeutic applications

British Journal of Pharmacology, EarlyView.
Comparative metabolomic and transcriptomic profiling reveals distinct metabolic shifts and reduced proliferation in 3D MSC spheroids, providing insights to optimise MSC‐based therapies. Abstract Background and Purpose Mesenchymal stem cells (MSCs) are used widely in regenerative medicine due to their multipotency and immunomodulatory properties ...
Manju Shrestha, Yun‐Seo Kil, Yunju Jo, Simmyung Yook, Ki Hyun Kim, Dongryeol Ryu, Joo‐Won Nam, Jee‐Heon Jeong   +7 more
wiley   +1 more source

Anaerobic Glycolysis is the Main Pathway for Energy Generation in Hl-60 Acute Promyelocytic Leukemia Cells

, 2010

openalex   +2 more sources

Microbial and Metabolic Disorders in Cervical Cancer: Structural Insights, Biomarkers, Mechanisms, and Therapeutic Strategies

Cancer Science, EarlyView.
We unravel synergistic mechanisms by which microbial‐host metabolic networks regulate the tumor immune microenvironment and therapy resistance, bridging gaps between microbiota research and cancer metabolism. Identified biomarkers (e.g., Lactobacillus, C8‐ceramide‐1‐phosphate) and therapeutic approaches (e.g., FMT combined with immune checkpoint ...
Hong Tao, Luyu Wang, Yi Ding, Lixian Yi, Mutian Han, Mengmeng Gu, Jian Wu   +6 more
wiley   +1 more source

FAM111B Suppression Enhances Sensitivity to Gemcitabine in Pancreatic Cancer Through Intracellular pH Regulation

Cancer Science, EarlyView.
Family with Sequence Similarity 111 Member B (FAM111B), cysteine/serine peptidase with molecular targets, are upregulated under acidic conditions. FAM111B suppression increased the sensitivity to gemcitabine through intracellular pH regulation. Moreover, FAM111B expression is correlated with poorer overall survival in pancreatic cancer patients ...
Motonobu Nishimura, Masaki Sunagawa, Toshio Kokuryo, Junpei Yamaguchi, Taisuke Baba, Takashi Mizuno, Shunsuke Onoe, Nobuyuki Watanabe, Shoji Kawakatsu, Tomoki Ebata   +9 more
wiley   +1 more source