Results 221 to 230 of about 335,029 (357)

The Ever‐Expanding Influence of the Endothelial Nitric Oxide Synthase

Basic &Clinical Pharmacology &Toxicology, Volume 136, Issue 5, May 2025.
ABSTRACT Nitric oxide (NO) generated by the endothelial NO synthase (eNOS) plays an essential role in the maintenance of vascular homeostasis and the prevention of vascular inflammation. There are a myriad of mechanisms that regulate the activity of the enzyme that may prove to represent interesting therapeutic opportunities.
Riham Rafea, Mauro Siragusa, Ingrid Fleming   +2 more
wiley   +1 more source

Low oxygen tension during IVM improves bovine oocyte competence and enhances anaerobic glycolysis.

Reproductive Biomedicine Online, 2010
P. Bermejo-Álvarez, Patrick Lonergan, D. Rizos, Alfonso Gutiérrez-Adán   +3 more
semanticscholar   +1 more source

Fecal Secretory Immunoglobulin A and Lactate Level as a Biomarker of Mucosal Immune Dysfunction in Horses With Colic

Journal of Veterinary Internal Medicine, Volume 39, Issue 3, May/June 2025.
ABSTRACT Background Colic‐related obstructions can reduced intestinal mucosa function and cause dysbiosis in horses, but it is unclear how defense barrier and secretory immunoglobulin A (SIgA) secretion is disrupted. Objectives The aim of the study is to evaluate the effect of severity of colic signs and treatments on fecal SIgA and fecal lactate in ...
Agnieszka Żak‐Bochenek, Zuzana Drábková, Vaiva Sergedaite, Natalia Siwińska, Joanna Bajzert, Dominika Pasak, Anna Chełmońska‐Soyta   +6 more
wiley   +1 more source

Nudix Hydrolase 13 Impairs the Initiation of Colorectal Cancer by Inhibiting PKM1 ADP‐Ribosylation

Advanced Science, Volume 12, Issue 13, April 3, 2025.
This study identified NUDT13 as a roadblock in the progression from colorectal adenoma to CRC, and revealed that NUDT13 stabilizes PKM1 protein by reducing the PARylation that is catalyzed by PARP1, thereby reprogramming the metabolic propensity of CRC cells.
Jinlong Lin, Yixin Yin, Jinghua Cao, Bingxu Zou, Kai Han, Yufan Chen, Siyu Li, Cijun Huang, Jiewei Chen, Yongrui Lv, Shuidan Xu, Dan Xie, Fengwei Wang   +12 more
wiley   +1 more source

Brain‐Wide Neuroregenerative Gene Therapy Improves Cognition in a Mouse Model of Alzheimer's Disease

Advanced Science, Volume 12, Issue 14, April 10, 2025.
NeuroD1 mediates brain‐wide astrocyte‐to‐neuron gene therapy conversion in 5xFAD mouse brain. Regenerated neurons can fire action potentials and integrate into pre‐existing neural networks, ultimately improving cognition in AD mice. Abstract Alzheimer's disease (AD) is a progressive and irreversible brain disorder with extensive neuronal loss in the ...
Zheng Wu, Liang Xu, Yu Xie, Abhijeet Sambangi, Shreya Swaminathan, Zifei Pei, Wenyu Ji, Zeru Li, Yaowei Guo, Zhifei Li, Gong Chen   +10 more
wiley   +1 more source

A Feedback Loop Driven by H4K12 Lactylation and HDAC3 in Macrophages Regulates Lactate‐Induced Collagen Synthesis in Fibroblasts Via the TGF‐β Signaling

Advanced Science, Volume 12, Issue 13, April 3, 2025.
Low concentrations of lactate are transported to macrophages via MCT1, which upregulates the levels of histone H4K12la and promotes the transcription and secretion of TGF‐β in macrophages. TGF‐β subsequently enters fibroblasts through TGF‐β receptors, stimulating collagen synthesis.
Ying Zou, Mibu Cao, Meiling Tai, Haoxian Zhou, Li Tao, Shu Wu, Kaiye Yang, Youliang Zhang, Yuanlong Ge, Hao Wang, Shengkang Luo, Zhenyu Ju   +11 more
wiley   +1 more source

Additional file 2 of Enforcing ATP hydrolysis enhanced anaerobic glycolysis and promoted solvent production in Clostridium acetobutylicum

, 2021
Zongjie Dai, Yan Zhu, Hongjun Dong, Chunhua Zhao, Yanping Zhang, Yin Li   +5 more
openalex   +2 more sources

ACAT1‐Mediated ME2 Acetylation Drives Chemoresistance in Ovarian Cancer by Linking Glutaminolysis to Lactate Production

Advanced Science, Volume 12, Issue 14, April 10, 2025.
Chemotherapy reduces glucose transporter expression and glucose uptake in cancer cells, leading to decreased pyruvate levels. This decline prompts ACAT1‐mediated acetylation of ME2 at Lys156, enhancing ME2 activity and promoting lactate production from glutamine.
Cuimiao Zheng, Hao Tan, Gang Niu, Xi Huang, Jingyi Lu, Siqi Chen, Haoyuan Li, Jiayu Zhu, Zhou Zhou, Manman Xu, Chaoyun Pan, Junxiu Liu, Jie Li   +12 more
wiley   +1 more source

Bufalin-Loaded Multifunctional Photothermal Nanoparticles Inhibit the Anaerobic Glycolysis by Targeting SRC-3/HIF-1α Pathway for Improved Mild Photothermal Therapy in CRC. [PDF]

Int J Nanomedicine
Shang J, Xia Q, Sun Y, Wang H, Chen J, Li Y, Gao F, Yin P, Yuan Z.   +8 more
europepmc   +1 more source

Prophylactic Fetal Creatine Supplementation Improves Post‐Asphyxial EEG Recovery and Reduces Seizures in Fetal Sheep: Implications for Hypoxic–Ischemic Encephalopathy

Annals of Neurology, Volume 97, Issue 4, Page 673-687, April 2025.
Objective Hypoxic–ischemic encephalopathy (HIE) is a major cause of perinatal brain injury. Creatine is a dietary supplement that can increase intracellular phosphocreatine to improve the provision of intracellular adenosine triphosphate (ATP) to meet the increase in metabolic demand of oxygen deprivation.
Nhi T. Tran, Stacey J. Ellery, Sharmony B. Kelly, Juliane Sévigny, Madeleine Chatton, Hui Lu, Graeme R. Polglase, Rod J. Snow, David W. Walker, Robert Galinsky   +9 more
wiley   +1 more source