Results 31 to 40 of about 334,223 (370)

ANAEROBIC GLYCOLYSIS OF THE BRAIN IN EXPERIMENTAL POLIOMYELITIS [PDF]

Journal of Experimental Medicine, 1945
The rate of anaerobic glycolysis of brain tissue was compared for normal animals and animals with experimentally induced poliomyelitis, using two different strains of mice and two different procedures. The report of interference of poliomyelitis with anaerobic glycolysis of brain was not confirmed.
John M. Reiner, Irving I. Rusoff, Harland G. Wood   +2 more
openaire   +3 more sources

How germline genes promote malignancy in cancer cells

BioEssays, Volume 45, Issue 1, January 2023., 2023
We hypothesize that activation of a “germline program” promotes oncogenesis. Expression of otherwise germline specific genes may result in pseudomeiotic activity, thereby promoting oncogenesis through genomic instability. Other processes that are differentially regulated in the germline, such as migration and epigenetic – and metabolic plasticity, may ...
Jan Willem Bruggeman, Jan Koster, Ans M. M. van Pelt, Dave Speijer, Geert Hamer   +4 more
wiley   +1 more source

Metabolic Switch and Cytotoxic Effect of Metformin on Burkitt Lymphoma

Frontiers in Oncology, 2021
Altered cellular energetic metabolism has recently emerged as important feature of neoplastic cells. Indeed, interfering with cancer cell metabolism might represent a suitable therapeutic strategy.
Irene Bagaloni, Axel Visani, Sara Biagiotti, Annamaria Ruzzo, Mohsen Navari, Mohsen Navari, Mohsen Navari, Maryam Etebari, Maryam Etebari, Lucia Mundo, Lucia Mundo, Massimo Granai, Massimo Granai, Stefano Lazzi, Alessandro Isidori, Federica Loscocco, Jiejin Li, Lorenzo Leoncini, Giuseppe Visani, Mauro Magnani, Pier Paolo Piccaluga, Pier Paolo Piccaluga, Pier Paolo Piccaluga, Pier Paolo Piccaluga   +23 more
doaj   +1 more source

Notch signaling regulates metabolic heterogeneity in glioblastoma stem cells. [PDF]

, 2017
Glioblastoma (GBM) stem cells (GSCs) reside in both hypoxic and vascular microenvironments within tumors. The molecular mechanisms that allow GSCs to occupy such contrasting niches are not understood.
Barcellos-Hoff, Mary Helen, Bayin, N Sumru, Chesler, Mitch, Chiriboga, Luis, Dolgalev, Igor, Doyle, Werner, Frenster, Joshua D, Galifianakis, Nataliya, Golfinos, John G, Heguy, Adriana, Illa-Bochaca, Irineu, Khahera, Anadjeet, Modrek, Aram S, Ortenzi, Valerio, Placantonakis, Dimitris G, Sen, Rajeev, Serrano, Jonathan, Si, Sheng, Snuderl, Matija, Tsirigos, Aristotelis, Zagzag, David   +20 more
core   +5 more sources

Synaptic modifications transform neural networks to function without oxygen

BMC Biology, 2023
Background Neural circuit function is highly sensitive to energetic limitations. Much like mammals, brain activity in American bullfrogs quickly fails in hypoxia.
Lara Amaral-Silva, Joseph M. Santin
doaj   +1 more source

Explicit consideration of topological and parameter uncertainty gives new insights into a well-established model of glycolysis [PDF]

, 2013
Previous models of glycolysis in the sleeping sickness parasite Trypanosoma brucei assumed that the core part of glycolysis in this unicellular parasite is tightly compartimentalized within an organelle, the glycosome, which had previously been shown to ...
Achcar, Albert, Bakker, Bakker, Bakker, Bakker, Blattner, Chevalier, Clarkson, Clarkson, Cronín, Fairlamb, Fairlamb, Gualdron-López, Gualdrón-López, Guerra-Giraldez, Haanstra, Haanstra, Hammond, Helfert, Häusler, Michels, Miškovíc, Murabito, Opperdoes, Rizk, Satish Kumar, Steiger, Tran, Visser, Wang   +30 more
core   +1 more source

Sugarcane mosaic virus orchestrates the lactate fermentation pathway to support its successful infection

Frontiers in Plant Science, 2023
Viruses often establish their own infection by altering host metabolism. How viruses co-opt plant metabolism to support their successful infection remains an open question.
Tong Jiang, Tong Jiang, Kaitong Du, Pei Wang, Xinhai Wang, Lianyi Zang, Dezhi Peng, Xi Chen, Geng Sun, Hao Zhang, Zaifeng Fan, Zhiyan Cao, Tao Zhou   +12 more
doaj   +1 more source

Mutated FANCA Gene Role in the Modulation of Energy Metabolism and Mitochondrial Dynamics in Head and Neck Squamous Cell Carcinoma

Cells, 2022
Fanconi Anaemia (FA) is a rare recessive genetic disorder characterized by a defective DNA repair mechanism. Although aplastic anaemia is the principal clinical sign in FA, patients develop a head and neck squamous cell carcinoma (HNSCC) with a frequency
Nadia Bertola, Paolo Degan, Enrico Cappelli, Silvia Ravera   +3 more
doaj   +1 more source

Heterogeneity and proliferation of invasive cancer subclones in game theory models of the Warburg effect [PDF]

, 2015
OBJECTIVES: The Warburg effect, the switch from aerobic energy production to anaerobic glycolysis, promotes tumour proliferation and motility by inducing acidification of the tumour microenvironment.
Archetti, Archetti, Archetti, Archetti, Archetti, Archetti, Bach, Basanta, Basanta, Basanta, Bergers, Bhujwalla, Buchler, Casciari, Feron, Gambhir, Gatenby, Gatenby, Gatenby, Gatenby, Gillies, Griffiths, Hanahan, He, Ibrahim Hashim, Ibrahim Hashim, Kelloff, Kianercy, Kunkel, Lardner, Martin, Martin, Maynard Smith, Mochiki, Park, Patel, Pauwels, Perc, Postovit, Postovit, Rajendran, Robey, Rohzin, Rubin, Schornack, Semenza, Shi, Silva, Smallbone, Smallbone, Sonveaux, Tomlinson, Tomlinson, Warburg, Williams, Wojtkowiak   +55 more
core   +1 more source

Impact of Salmonella genome rearrangement on gene expression

Evolution Letters, Volume 6, Issue 6, Page 426-437, December 2022., 2022
Abstract In addition to nucleotide variation, many bacteria also undergo changes at a much larger scale via rearrangement of their genome structure (GS) around long repeat sequences. These rearrangements result in genome fragments shifting position and/or orientation in the genome without necessarily affecting the underlying nucleotide sequence.
Emma V. Waters, Liam A. Tucker, Jana K. Ahmed, John Wain, Gemma C. Langridge   +4 more
wiley   +1 more source