Results 61 to 70 of about 341,458 (322)

The role and mechanism of histone lactylation in health and diseases

Frontiers in Genetics, 2022
Whether under anaerobic or aerobic conditions, glycolysis results in production of lactate. Increasing evidence suggests that lactate serves as a multifunctional signaling molecule that develops non-metabolic activities in addition to serving as a key ...
Yumei Xie, Hongxia Hu, Maoting Liu, Tingting Zhou, Xi Cheng, Wei Huang, Ling Cao   +6 more
doaj   +1 more source

Interrelationship between contractility, protein synthesis and metabolism in mantle of juvenile cuttlefish (Sepia officinalis) [PDF]

, 2019
Young juvenile cuttlefish (Sepia officinalis) can grow at rates as high as 12% body weight per day. How the metabolic demands of such a massive growth rate impacts muscle performance that competes for ATP is unknown.
Bamford, Bartol, Biolo, Capaz, Carter, Dizon, Driedzic, Forsythe, Fraser, Gibala, Grieshaber, Gäde, Johansen, Kitasato, Lamarre, Lamarre, Lamarre, Langer, Layland, Lewbart, Losito, Martínez-Quintana, McCully, Melzner, Milligan, Moltschaniwskyj, Nakamura, Okamoto, O’Dor, O’Dor, Phillips, Pörtner, Ruff, Sandow, Seibel, Seibel, Sepp, Shiels, Short, Speers-Roesch, Storey, Sykes, Sykes, Sykes, Sykes, Trueman, van Os, Wong, Wong, Xu   +49 more
core   +1 more source

Glycolytic reprograming in Salmonella counters NOX2-mediated dissipation of ΔpH. [PDF]

, 2020
The microbial adaptations to the respiratory burst remain poorly understood, and establishing how the NADPH oxidase (NOX2) kills microbes has proven elusive. Here we demonstrate that NOX2 collapses the ΔpH of intracellular Salmonella Typhimurium.
Chakraborty, Sangeeta, Desai, Prerak, Fitzsimmons, Liam, Kim, Ju-Sim, Liu, Lin, McClelland, Michael, Porwollik, Steffen, Vazquez-Torres, Andres   +7 more
core  

Effect of anhydrous betaine and hydrochloride betaine on growth performance, meat quality, postmortem glycolysis, and antioxidant capacity of broilers

Poultry Science, 2022
: This study was conducted to investigate the effect of anhydrous betaine and hydrochloride betaine on growth performance, meat quality, relaxometry, postmortem glycolysis, and antioxidant capacity of partridge shank broiler chickens.
R. Chen, M. Yang, Y.D. Song, R.X. Wang, C. Wen, Q. Liu, Y.M. Zhou, S. Zhuang   +7 more
doaj  

Mechanisms of adaptation to intensive loads of 400 meters’ hurdles runners at stage of initial basic training

Physical education of students, 2015
Purpose: is study of adaptation mechanisms of 400 meter’ hurdles-runners to intensive physical loads. Material: in the research 13 - 400 meters’ hurdles-runners and 13 - 400 meters’ runners participated.
A.S. Rovniy, V.M. Lastochkin
doaj   +1 more source

Pyruvate Kinase M2 and Cancer: The Role of PKM2 in Promoting Tumorigenesis

Frontiers in Oncology, 2020
Pyruvate kinase plays a pivotal role in regulating cell metabolism. The final and rate-limiting step of glycolysis is the conversion of Phosphoenolpyruvate (PEP) to Pyruvate, which is catalyzed by Pyruvate Kinase. There are four isomeric, tissue-specific
Kulsoom Zahra, Tulika Dey, Ashish, Surendra Pratap Mishra, Uma Pandey   +4 more
doaj   +1 more source

CO2 fixation by anaerobic non-photosynthetic mixotrophy for improved carbon conversion

Nature Communications, 2016
Microbial fermentation yield is limited by CO2 loss in glycolysis. Here, the authors engineered Clostridium ljungdahlii for the anaerobic, non-photosynthetic mixotrophy production of acetone, increasing carbon product yield while reducing CO2emissions ...
Shawn W. Jones, Alan G. Fast, Ellinor D. Carlson, Carrissa A. Wiedel, Jennifer Au, Maciek R. Antoniewicz, Eleftherios T. Papoutsakis, Bryan P. Tracy   +7 more
doaj   +1 more source

Warburg Effect, Glutamine, Succinate, Alanine, When Oxygen Matters

Biology, 2021
Cellular bioenergetics requires an intense ATP turnover that is increased further by hypermetabolic states caused by cancer growth or inflammation. Both are associated with metabolic alterations and, notably, enhancement of the Warburg effect (also known
Frédéric Bouillaud, Noureddine Hammad, Laurent Schwartz   +2 more
doaj   +1 more source

Protonophore activity of short‐chain fatty acids induces their intracellular accumulation and acidification

FEBS Letters, EarlyView.
The protonated form of butyrate, as well as other short‐chain fatty acids (SCFAs), is membrane permeable. In acidic extracellular environments, this can lead to intracellular accumulation of SCFAs and cytosolic acidification. This phenomenon will be particularly relevant in acidic environments such as the large intestine or tumor microenvironments ...
Muwei Jiang, Frans Bianchi, Geert van den Bogaart   +2 more
wiley   +1 more source

Transcriptomic signature of Leishmania infected mice macrophages: a metabolic point of view.

PLoS Neglected Tropical Diseases, 2012
We analyzed the transcriptional signatures of mouse bone marrow-derived macrophages at different times after infection with promastigotes of the protozoan parasite Leishmania major.
Imen Rabhi, Sameh Rabhi, Rym Ben-Othman, Axel Rasche, Adriani Daskalaki, Bernadette Trentin, David Piquemal, Béatrice Regnault, Albert Descoteaux, Lamia Guizani-Tabbane, Sysco Consortium   +10 more
doaj   +1 more source