Results 81 to 90 of about 334,223 (370)

Interrelationship between contractility, protein synthesis and metabolism in mantle of juvenile cuttlefish (Sepia officinalis) [PDF]

, 2019
Young juvenile cuttlefish (Sepia officinalis) can grow at rates as high as 12% body weight per day. How the metabolic demands of such a massive growth rate impacts muscle performance that competes for ATP is unknown.
Bamford, Bartol, Biolo, Capaz, Carter, Dizon, Driedzic, Forsythe, Fraser, Gibala, Grieshaber, Gäde, Johansen, Kitasato, Lamarre, Lamarre, Lamarre, Langer, Layland, Lewbart, Losito, Martínez-Quintana, McCully, Melzner, Milligan, Moltschaniwskyj, Nakamura, Okamoto, O’Dor, O’Dor, Phillips, Pörtner, Ruff, Sandow, Seibel, Seibel, Sepp, Shiels, Short, Speers-Roesch, Storey, Sykes, Sykes, Sykes, Sykes, Trueman, van Os, Wong, Wong, Xu   +49 more
core   +1 more source

Polyplex Nanomicelle‐Mediated Pgc‐1α4 mRNA Delivery Via Hydrodynamic Limb Vein Injection Enhances Damage Resistance in Duchenne Muscular Dystrophy Mice

Advanced Science, EarlyView.
This study presents a novel approach for treating Duchenne muscular dystrophy using mRNA encoding PGC‐1α4. Nanomicelle‐delivered Pgc‐1α4 mRNA enhances muscle damage resistance and mitochondrial activity in dystrophic muscles. This study demonstrates the potential of mRNA therapy for neuromuscular diseases like Duchenne muscular dystrophy and highlights
Xuan Du, Hideyuki Nakanishi, Takashi Yamada, Yooksil Sin, Katsura Minegishi, Norio Motohashi, Yoshitsugu Aoki, Keiji Itaka   +7 more
wiley   +1 more source

Effect of anhydrous betaine and hydrochloride betaine on growth performance, meat quality, postmortem glycolysis, and antioxidant capacity of broilers

Poultry Science, 2022
: This study was conducted to investigate the effect of anhydrous betaine and hydrochloride betaine on growth performance, meat quality, relaxometry, postmortem glycolysis, and antioxidant capacity of partridge shank broiler chickens.
R. Chen, M. Yang, Y.D. Song, R.X. Wang, C. Wen, Q. Liu, Y.M. Zhou, S. Zhuang   +7 more
doaj  

Pyruvate Kinase M2 and Cancer: The Role of PKM2 in Promoting Tumorigenesis

Frontiers in Oncology, 2020
Pyruvate kinase plays a pivotal role in regulating cell metabolism. The final and rate-limiting step of glycolysis is the conversion of Phosphoenolpyruvate (PEP) to Pyruvate, which is catalyzed by Pyruvate Kinase. There are four isomeric, tissue-specific
Kulsoom Zahra, Tulika Dey, Ashish, Surendra Pratap Mishra, Uma Pandey   +4 more
doaj   +1 more source

Minimizing acetate formation in E. coli fermentations [PDF]

, 2007
Escherichia coli remains the best established production organisms in industrial biotechnology. However, during aerobic fermentation runs at high growth rates, considerable amounts of acetate are accumulated as by-product.
De Maeseneire, Sofie, De Mey, Marjan, Soetaert, Wim, Vandamme, Erick   +3 more
core   +2 more sources

Nudix Hydrolase 13 Impairs the Initiation of Colorectal Cancer by Inhibiting PKM1 ADP‐Ribosylation

Advanced Science, EarlyView.
This study identified NUDT13 as a roadblock in the progression from colorectal adenoma to CRC, and revealed that NUDT13 stabilizes PKM1 protein by reducing the PARylation that is catalyzed by PARP1, thereby reprogramming the metabolic propensity of CRC cells.
Jinlong Lin, Yixin Yin, Jinghua Cao, Bingxu Zou, Kai Han, Yufan Chen, Siyu Li, Cijun Huang, Jiewei Chen, Yongrui Lv, Shuidan Xu, Dan Xie, Fengwei Wang   +12 more
wiley   +1 more source

CO2 fixation by anaerobic non-photosynthetic mixotrophy for improved carbon conversion

Nature Communications, 2016
Microbial fermentation yield is limited by CO2 loss in glycolysis. Here, the authors engineered Clostridium ljungdahlii for the anaerobic, non-photosynthetic mixotrophy production of acetone, increasing carbon product yield while reducing CO2emissions ...
Shawn W. Jones, Alan G. Fast, Ellinor D. Carlson, Carrissa A. Wiedel, Jennifer Au, Maciek R. Antoniewicz, Eleftherios T. Papoutsakis, Bryan P. Tracy   +7 more
doaj   +1 more source

Brain‐Wide Neuroregenerative Gene Therapy Improves Cognition in a Mouse Model of Alzheimer's Disease

Advanced Science, EarlyView.
NeuroD1 mediates brain‐wide astrocyte‐to‐neuron gene therapy conversion in 5xFAD mouse brain. Regenerated neurons can fire action potentials and integrate into pre‐existing neural networks, ultimately improving cognition in AD mice. Abstract Alzheimer's disease (AD) is a progressive and irreversible brain disorder with extensive neuronal loss in the ...
Zheng Wu, Liang Xu, Yu Xie, Abhijeet Sambangi, Shreya Swaminathan, Zifei Pei, Wenyu Ji, Zeru Li, Yaowei Guo, Zhifei Li, Gong Chen   +10 more
wiley   +1 more source

Mechanisms of adaptation to intensive loads of 400 meters’ hurdles runners at stage of initial basic training

Physical Education of Students, 2015
Purpose: is study of adaptation mechanisms of 400 meter’ hurdles-runners to intensive physical loads. Material: in the research 13 - 400 meters’ hurdles-runners and 13 - 400 meters’ runners participated.
A.S. Rovniy, V.M. Lastochkin
doaj   +1 more source

Lactate activates HIF-1 in oxidative but not in Warburg-phenotype human tumor cells. [PDF]

PLoS ONE, 2012
Cancer can be envisioned as a metabolic disease driven by pressure selection and intercellular cooperativeness. Together with anaerobic glycolysis, the Warburg effect, formally corresponding to uncoupling glycolysis from oxidative phosphorylation ...
Christophe J De Saedeleer, Tamara Copetti, Paolo E Porporato, Julien Verrax, Olivier Feron, Pierre Sonveaux   +5 more
doaj   +1 more source