Results 81 to 90 of about 341,458 (322)

LC-MS proteomics analysis of the iInsulin/IGF-1-deficient Caenorhabditis elegans daf-2(e1370) mutant reveals extensive restructuring of intermediary metabolism [PDF]

, 2014
The insulin/IGF-1 receptor is a major known determinant of dauer formation, stress resistance, longevity, and metabolism in Caenorhabditis elegans. In the past, whole-genome transcript profiling was used extensively to study differential gene expression ...
Braeckman, Bart, Brewer, Heather M, Camp, David G, II, Depuydt, Geert, Petyuk, Vladislav A, Smith, Richard D, Smolders, Arne, Xie, Fang   +7 more
core   +2 more sources

Lactate‐Activated GPR132‐Src Signal Induces Macrophage Senescence and Aggravates Atherosclerosis Under Diabetes

Advanced Science, EarlyView.
Elevated lactate in diabetes activates the GPR132‐Src pathway in macrophages, inducing macrophage senescence and further enhancing foam cell formation. This mechanism exacerbates atherosclerotic progression. Abstract Diabetes is widely acknowledged as a significant risk factor for atherosclerosis, facilitating plaque formation through various ...
Xiaofeng Ge, Shuying Wang, Zhaokai Li, Jing Yu, Binbin Liu, Ruiying Wang, Shichen Bu, Nawsher wan, Yan Wang, Cuilian Dai, Yijun Lin   +10 more
wiley   +1 more source

AuCu@CuO2 Aerogels with H2O2/O2 Self‐Supplying and Quadruple Enzyme‐Like Activity for MRSA‐Infected Diabetic Wound Management

Advanced Science, EarlyView.
The AuCu@CuO2 aerogels demonstrate favorable photothermal properties, four types of enzyme‐like activities, and H2O2/O2 self‐supplying to modulate the complex microenvironment of MRSA‐infected diabetic wounds. The results indicate that the AuCu@CuO2 aerogel can be activated by the microenvironment of diabetic wound infection, alleviating inflammation ...
Xiaofeng Tan, Nanyun Lin, Sha Yang, Hongyu Gong, Minghui Wang, Na Li, Fen Liu, Dajun Rao, Yingying Wu, Jing Tang, Qinglai Yang   +10 more
wiley   +1 more source

Mechanistic Foundations of KRAS‐Driven Tumor Ecosystems: Integrating Crosstalk among Immune, Metabolic, Microbial, and Stromal Microenvironment

Advanced Science, EarlyView.
KRAS mutations dynamically remodel the tumor microenvironment (TME), fostering immunosuppression, metabolic symbiosis, and stromal plasticity. This review dissects how oncogenic KRAS variants sculpt TME networks and explores actionable vulnerabilities. Emerging strategies combining KRAS inhibitors and TME‐editing approaches offer potential to dismantle
Jiayao Ma, Shenao Fu, Jun Tan, Ying Han, Yihong Chen, Xiangying Deng, Hong Shen, Shan Zeng, Yinghui Peng, Changjing Cai   +9 more
wiley   +1 more source

A broad distribution of the alternative oxidase in microsporidian parasites [PDF]

, 2010
Microsporidia are a group of obligate intracellular parasitic eukaryotes that were considered to be amitochondriate until the recent discovery of highly reduced mitochondrial organelles called mitosomes. Analysis of the complete genome of Encephalitozoon
A Atteia, A Stechmann, AD Tsaousis, AE McDonald, AL Moore, AL Moore, AL Umbach, Anthony L. Moore, AV Goldberg, BA Williams, BA Williams, BA Williams, Bryony A. P. Williams, C Affourtit, C Larsson, C Nihei, Catherine Elliot, CH Slamovits, CR Vossbrinck, CW Roberts, DA Berthold, DE Akiyoshi, E Weidner, ES Didier, ES Didier, F Thomarat, GC Vanlerberghe, GV Beznoussenko, I Small, JA Eisen, JD Thompson, JP Huelsenbeck, K Kita, Kiyoshi Kita, Lena Burri, M Chaudhuri, M Nina, MD Katinka, MG Claros, MJ Gardner, MS Albury, MS Albury, MS Albury, N Minagawa, O Emanuelsson, P Stenmark, Patricia J. Johnson, Patrick J. Keeling, PG Crichton, PJ Didier, PJ Keeling, R George, RP Hirt, RS Cornman, S Guindon, SJ Qureshi, T Joseph-Horne, T Suzuki, TA Richards, TD Edlind, TE Elthon, TM Keane, W Jarmuszkiewicz, Y Fukai, Yasutoshi Kido   +64 more
core   +4 more sources

Hexokinase‐2 as a Therapeutic Target: Alleviating Herpes Simplex Keratitis Through Metabolic Reprogramming

Advanced Science, EarlyView.
Herpes Simplex Virus Type 1 (HSV‐1) infection triggers metabolic reprogramming in corneal cells, shifting from mitochondrial respiration to aerobic glycolysis with marked upregulation of Hexokinase‐2 (HK2). This study identifies HK2 as a therapeutic target: inhibiting HK2 with lonidamine significantly reduces viral replication and promotes corneal ...
Dan Jiang, Yining Sun, Xintong Yu, Ruoqi Wang, Yuting Zhang, Jinjie Yu, Shuang Xie, Yujia Cai, Yuhong Luo, Wei Chen   +9 more
wiley   +1 more source

Studies with a reconstituted muscle glycolytic system. The rate and extent of creatine phosphorylation by anaerobic glycolysis.

Biochemical Journal, 1973
A mixture of purified muscle glycolytic enzymes was reconstituted and the mixture shown to behave in a fashion analogous to that occurring in vivo. Glycolysis leads to ATP production in muscle and results in the phosphorylation of creatine. The extent of
R. Scopes
semanticscholar   +1 more source

Glycolytic activity of the tissue stem cells in the macula flava of the human vocal fold

Laryngoscope Investigative Otolaryngology, 2021
Objectives In our previous studies, the features of the mitochondria of tissue stem cells in the maculae flavae of the human vocal fold suggested that their metabolic activity and oxidative phosphorylation was low.
Kiminori Sato, Shun‐ichi Chitose, Kiminobu Sato, Fumihiko Sato, Takeharu Ono, Hirohito Umeno   +5 more
doaj   +1 more source

HPD is an RNA‐Binding Protein Sustaining Ovarian Cancer Cell Glycolysis, Tumor Growth, and Drug Resistance

Advanced Science, EarlyView.
HPD is identified as an RNA‐binding protein that promotes mRNA translation by binding to RRACH motifs via its double‐stranded RNA‐binding domains. This RNA‐binding activity critically sustains glycolysis in ovarian cancer cells. Disrupting HPD's RNA‐binding function effectively suppresses tumor growth and enhances therapeutic sensitivity, highlighting ...
Fei Xie, Han Zhang, Xintong Dai, Mengxin Tu, Chenxi Yu, Lumeng Liu, Yajuan Guo, Huanran Sun, Qingle Gao, Jiyan Wang, Mingming Sun, Qijun Zhang, Taoyuan Wang, Tao He, Zhen Li, Yanping Li, Tao Wang, Jianguo Zhao, Zhongjie Chen, Chunze Zhang, Shuai Zhang, Changliang Shan   +21 more
wiley   +1 more source

Exposure of Mycobacterium abscessus to Environmental Stress and Clinically Used Antibiotics Reveals Common Proteome Response among Pathogenic Mycobacteria

Microorganisms, 2020
Mycobacterium abscessus subsp. abscessus (MAB) is a clinically important nontuberculous mycobacterium (NTM) causing pulmonary infection in patients such as cystic fibrosis and bronchiectasis.
Rajoana Rojony, Lia Danelishvili, Anaamika Campeau, Jacob M. Wozniak, David J. Gonzalez, Luiz E. Bermudez   +5 more
doaj   +1 more source