Results 91 to 100 of about 395,234 (289)

Identification of HSP90B1 in pan-cancer hallmarks to aid development of a potential therapeutic target

open access: yesMolecular Cancer
Heat shock proteins play crucial roles in various biochemical processes, encompassing protein folding and translocation. HSP90B1, a conserved member of the heat shock protein family, growing evidences have demonstrated that it might be closely associated
Xiaoliang Huang   +11 more
doaj   +1 more source

Unveiling a New Link: Cholesterol Deficiency in Smith–Lemli–Opitz and Niemann–Pick C as a Driver of Ciliopathies

open access: yesAmerican Journal of Medical Genetics Part A, EarlyView.
ABSTRACT The ciliopathies are a group of genetic disorders caused by defective function of either the primary cilia (a large number) or the motile cilia (a much smaller number). These have been defined as diseases with mutations in genes encoding individual ciliary or cilia‐associated proteins.
Robert P. Erickson   +1 more
wiley   +1 more source

SREBP2 as a central player in cancer progression: potential for targeted therapeutics

open access: yesFrontiers in Pharmacology
Recent studies have identified the reprogramming of lipid metabolism as a critical hallmark of malignancy. Enhanced cholesterol uptake and increased cholesterol biosynthesis significantly contribute to the rapid growth of tumors, with cholesterol also ...
Ruiqi Chen   +11 more
doaj   +1 more source

Anorectal Melanoma [PDF]

open access: yes, 2018
Anorectal melanoma (AM) is a rare malignancy, characterized by aggressive behavior and a poor prognosis. AM is more frequent in female patients aged over 50 years.
Dario Didona   +4 more
core   +1 more source

Structural and Biological Insights Into Copper(I) Phosphane Complexes With Boron‐Phenylated Poly(3‐(CF3)Pyrazolyl)‐ and Poly(6‐(CF3)‐2‐pyridyl)‐Borates

open access: yesChemistry – A European Journal, EarlyView.
This study reports six new copper(I) complexes with unusual coordination and strong anticancer activity against a panel of human cancer cell lines derived from different solid tumors. The most active compounds outperform cisplatin, even in resistant cells, by inhibiting protein disulfide isomerase and inducing redox stress that triggers non‐apoptotic ...
Vo Quang Huy Phan   +9 more
wiley   +1 more source

Mesoporous multimetallic PdPtBi nanozymes target redox imbalance and glutamine deprivation for immuno-chemodynamic therapy

open access: yesJournal of Nanobiotechnology
Therapeutic resistance remains a formidable challenge in oncology, mainly due to the chaotic tumor microenvironment (TME), which drive tumor progression and adaptive resistance via a self-sustaining metabolic–oxidative feedback loop.
Guanhua Qiu   +9 more
doaj   +1 more source

COLOR III: a multicentre randomised clinical trial comparing transanal TME versus laparoscopic TME for mid and low rectal cancer [PDF]

open access: yes, 2015
Total mesorectal excision (TME) is an essential component of surgical management of rectal cancer. Both open and laparoscopic TME have been proven to be oncologically safe.
Bonjer, HJ   +9 more
core   +1 more source

Building a Robust Investigator‐Initiated Platform: The I‐CARE Experience

open access: yesClinical Pharmacology &Therapeutics, EarlyView.
Investigator‐initiated studies that include information collected by patients are rising, but limited data is available on patient and investigator experience in this setting. The I‐CARE cohort included patients with inflammatory bowel disease (IBD) monthly collecting clinical information in 15 countries for up to 6 years.
Julien Kirchgesner   +906 more
wiley   +1 more source

Pathogenesis and potential therapeutic targets of trichorhinophalangeal syndrome; lessons obtained from animal studies

open access: yesDevelopmental Dynamics, EarlyView.
Abstract Trichorhinophalangeal syndrome (TRPS) is a rare genetic disease inherited in an autosomal dominant manner. It occurs in 1 in 100,000 people globally and is caused by several types of mutations of the TRPS1 gene. Since the first human patient was reported in 1966, typical and atypical pathologies, disease courses, and treatment case ...
Naoya Saeki   +6 more
wiley   +1 more source

Clearance of human papillomavirus related anal condylomas after oral and endorectal multistrain probiotic supplementation in an HIV positive male: A case report. [PDF]

open access: yes, 2018
Go to: Introduction: Here we present the case of a 56-year-old human immunodeficiency virus (HIV)-infected man with multiple anal condylomas and positivity for human papilloma virus (HPV) 18 on anal brushing.
Bianchi, L   +7 more
core   +1 more source

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