Results 41 to 50 of about 89,708 (258)

Multi‐Component Functionalized Bifidobacterium Longum Hydrogel for Multi‐Target Integrated Therapy of Colitis‐Associated Anxiety and Depression

Advanced Science, EarlyView.
A pH/MMP dual‐responsive Bifidobacterium longum (BL) hydrogel (INPs@BL@Gel) functionalized with baicalin, tyrosine, and inulin is constructed. It enables gastric protection, inflammation‐targeted release, and prolonged intestinal colonization. By remodeling gut microbiota, elevating beneficial neuroactive metabolites (homovanillic acid, short‐chain ...
Shuo Zhang, Yujie Zhang, Jiansheng He, Shunlian Li, Qingyan Ma, Qiao Li, Yudan Zhang, Yiyang Wang, Shaobo Ma, Songyan Jin, Chune Li, Xueyong Xie, Hang Zhang, Junze Deng, Xueqin Song, Daocheng Wu, Xiancang Ma, Feng Zhu   +17 more
wiley   +1 more source

Arginase 2 Promotes Colorectal Cancer Metastasis via PI3K/AKT Pathway Activation and Regulates Tumor Immune Infiltration

Cancer Medicine
Background Colorectal cancer (CRC) is a leading cause of cancer‐related deaths, with metabolic reprogramming involved in its pathogenesis. Aberrant Arginase 2 (ARG2) expression is linked to malignant progression, but its role in CRC remains unclear ...
Yueyan Zhang, Ning Qu, Jiale Mei, Caixia Mo, Luojuan Wei, Haixian Shen, Shanfei Zhou, Jinmin Hu, Wenqi Luo, Xianwei Mo   +9 more
doaj   +1 more source

Identification and predictive machine learning model construction of gut microbiota associated with carcinoembryonic antigens in colorectal cancer

mSphere
Carcinoembryonic antigen (CEA) is a critical colorectal cancer (CRC) biomarker, but its mechanistic link to gut microbiota remains unclear. This study characterized gut microbiota differences between high-CEA (H-CEA) and low-CEA (L-CEA) CRC patients and ...
Yongzhi Wu, Zigui Huang, Yongqi Huang, Chuanbin Chen, Mingjian Qin, Zhen Wang, Fuhai He, Shenghai Liu, Rumao Zhong, Jun Liu, Chenyan Long, Jungang Liu, Xiaoliang Huang   +12 more
doaj   +1 more source

Impact of Abdominoperineal Resection on Postoperative Male Sexual Function After Minimally Invasive Rectal Cancer Surgery: A Subgroup Analysis From the LANDMARC Study

Annals of Gastroenterological Surgery, EarlyView.
Abdominoperineal resection (APR) after minimally invasive rectal cancer surgery was associated with significantly higher rates of erectile and early ejaculatory dysfunction compared with anal‐sparing surgery. Although ejaculatory function showed partial recovery over time, erectile dysfunction persisted up to 12 months postoperatively.
Taiki Kajiwara, Shinobu Ohnuma, Michiaki Unno, Masakatsu Numata, Tomohiro Yamaguchi, Koya Hida, Tomonori Akagi, Suguru Hasegawa, Akio Shiomi, Ryo Inada, Manabu Shiozawa, Keisuke Kazama, Masanori Hotchi, Masahiko Watanabe, Takeshi Naitoh   +14 more
wiley   +1 more source

Exploring the gut microbiota associated with peripheral nerve invasion in colorectal cancer patients and constructing predictive models

BMC Microbiology
Objective This study aims to explore the differences in composition, abundance, and biological functions of the gut microbiota between colorectal cancer (CRC) patients with peripheral nerve invasion (PNI) and those without peripheral nerve invasion (NPNI)
Chuanbin Chen, Qingmin Chen, Shenghai Liu, Guoxi Li, Jiawei Zhao, Jingting Huang, Tianyi Ye, Xinting Yang, Zigui Huang, Zhen Wang, Fuhai He, Mingjian Qin, Chenyan Long, Binzhe Tang, Yongqi Huang, Weizhong Tang, Jungang Liu, Xiaoliang Huang   +17 more
doaj   +1 more source

Annual Report of the 2022 National Clinical Database: Decade‐Long Trends and Current Status of Gastroenterological Surgery in Japan

Annals of Gastroenterological Surgery, EarlyView.
ABSTRACT Aim The National Clinical Database (NCD) of Japan is the largest nationwide registry, covering over 95% of surgeries in the country. This 2022 annual report summarizes the short‐term outcomes of gastroenterological surgeries and discusses trends and insights over the past decade.
Koshi Kumagai, Arata Takahashi, Hideki Ueno, Naoki Hiki, Yoshiki Kajiwara, Tomoki Ebata, Takao Otsuka, Taro Oshikiri, Yoshihiro Kakeji, Takanori Goi, Akio Saiura, Hiroshi Saeki, Chie Tanaka, Masanori Tokunaga, Tsutomu Fujii, Satoru Matsuda, Tsunekazu Mizushima, Hiroyuki Yamamoto, Yuko Kitagawa, Ken Shirabe   +19 more
wiley   +1 more source

Comparison of Minimally Invasive Colectomy Between Intra‐ Versus Extra‐Corporeal Anastomosis Technique (COMMIT Study): Mid‐Term Analysis

Annals of Gastroenterological Surgery, EarlyView.
This multicenter retrospective cohort study compared mid‐term oncological outcomes between intracorporeal anastomosis (IA) and extracorporeal anastomosis (EA) in minimally invasive colectomy for colon cancer using propensity score–matched data from 2018 to 2022.
Takuya Takami, Takehito Yamamoto, Yoshiro Itatani, Ryosuke Mizuno, Shinya Hamasu, Keita Hanada, Kenji Kawada, Teppei Murakami, Satoshi Nagayama, Kazutaka Obama   +9 more
wiley   +1 more source

Relationship Between the Product of Pre‐Treatment Neutrophil and Monocyte Counts and Clinical Outcomes in Rectal Cancer With Suspected Lateral Lymph Node Metastasis

Annals of Gastroenterological Surgery, EarlyView.
ABSTRACT Aim A novel systemic inflammatory response marker, the neutrophil × monocyte value (NM value), has been identified as a negative predictive factor for responses to chemoradiotherapy in rectal cancer. However, the clinical implications of the NM value remain unknown.
Takayoshi Sasaki, Shinya Abe, Hiroaki Nozawa, Kazuhito Sasaki, Koji Murono, Shigenobu Emoto, Yuichiro Yokoyama, Yuzo Nagai, Yuzo Harada, Soichiro Ishihara   +9 more
wiley   +1 more source

Preoperative Computed Tomography Colonography‐Angiography for Vascular Mapping to Guide and Standardize D3 Lymphadenectomy in Right‐Sided and Transverse Colon Cancer

Annals of Gastroenterological Surgery, EarlyView.
This study utilized high‐resolution CT colonography‐angiography to systematically classify vascular branching patterns in 591 patients. We defined four reproducible anatomical patterns each for right hemicolectomy and transverse colectomy, demonstrating that an independent‐origin middle colic artery consistently predicts shorter dissection distances ...
Takeharu Kato, Yukihide Kanemitsu, Mototaka Miyake, Gen Tomizawa, Kohei Takura, Hiroshi Nagata, Yasuyuki Takamizawa, Konosuke Moritani, Shunsuke Tsukamoto   +8 more
wiley   +1 more source

Risk stratification and anal cancer screening in immunocompetent women with genital HPV: Value of multicentric HSIL and performance of HPV-based screening. [PDF]

Int J Cancer
What's new? Anal squamous cell carcinoma (ASCC) incidence is increasing, with most cases occurring in immunocompetent women. ASCC risk is linked in particular to genital human papillomavirus (HPV) infection and HPV‐associated high‐grade squamous intraepithelial lesions (HSILs).
Matas I, Torné A, Saco A, Martí C, Cardiel A, Rakislova N, Marimon L, Glickman A, Victoria I, Alós S, Lopez-Diaz J, Fusté P, Ordi J, Del Pino M.   +13 more
europepmc   +2 more sources