Results 91 to 100 of about 120,406 (302)

Nigra‐Subthalamic Dopaminergic Circuitry Modulates and Represents Distinct Pain Modality in Physiological and Pain States in Mice

Advanced Science, EarlyView.
Nigral dopaminergic (DA) neurons modulate and represent pain with a preference to a particular modality (mechanical) and laterality (contralateral), which are controlled by nigral GABAergic neurons. The pain modulation is mimicked by the nigro‐subthalamic projection and its downstream neurons, involving D2‐like receptors.
Ying Ji, Shuyi Li, Jiaqi Zhang, Xiang‐Ying Xu, Cui Yin, Mu Niu, Danyang Liu, Yanyu Jiang, Yong Niu, Su Liu, Bin Zhang, Guiyun Cui, Chunyi Zhou, Cheng Xiao   +13 more
wiley   +1 more source

Intravenous patient-controlled analgesia versus epidural anesthesia in the treatment of patients undergoing total hip arthroplasty: a retrospective comparative study

BMC Anesthesiology
Background Total hip arthroplasty is a common surgical procedure used to reduce pain and improve hip joint function in patients with advanced hip inflammation. Patient-controlled epidural analgesia is more effective in reducing postoperative anxiety.
Qian Wu, Xiao Jun Zhi
doaj   +1 more source

Randomized Controlled Trial of Epidural versus Patient-controlled Intravenous Analgesia for Postoperative Pain Control after Laparoscopic Gastrectomy [PDF]

, 2018
Although epidural analgesia (EDA) is considered standard postoperative analgesia for open gastrectomy, it has been unclear whether EDA has benefits in laparoscopic gastrectomy (LG) because postoperative pain after a laparoscopic procedure is ...
Fujiwara, Toshiyoshi, Kagawa, Shunsuke, Kikuchi, Satoru, Kuroda, Shinji, Kuwada, Kazuya, Matsusaki, Takashi, Mitsuhashi, Toshiharu, Morimatsu, Hiroshi, Nishizaki, Masahiko   +8 more
core   +1 more source

A NeuroD1 AAV‐Based Gene Therapy for Functional Brain Repair in Alzheimer's Disease‐Like Non‐Human Primate Model

Advanced Science, EarlyView.
This study tests NeuroD1 AAV‐based gene therapy in a non‐human primate Alzheimer's disease model. The therapy prevents neuronal damage, inhibits hippocampal atrophy, and reduces neuroinflammation. It also repairs vascular and blood‐brain barrier damage, restores cerebrospinal fluid biomarkers, enhances hippocampal glucose metabolism, and improves ...
Zhouquan Jiang, Yongpeng Qin, Bin Luo, Fan Bai, Jiangyue Liu, Long Ma, Shu He, Rongjie Chen, Yuchen Wang, Shanggong Liu, Ying Sun, Yi Chen, Shuo Zhang, Jiaqi Liang, Feng Liao, Huiyi Wei, Junjie Wei, Lu Wang, Hao Xu, Zheng Wu, Gong Chen, Wenliang Lei   +21 more
wiley   +1 more source

MANAGEMENT OF ACUTE PAIN IN PATIENT WITH PATIENT-CONTROLLED ANALGESIA

e-Jurnal Medika Udayana, 2013
Acute and chronic pain each has its own challenges because these patients are often dependent on opioids and have many psychosocial factors. None of these methods of pain control are superior than others.
Siska Permanasari Sinardja, IGN Mahaalit Aribawa   +1 more
doaj  

New patents on topical anesthetics. [PDF]

, 2014
Anesthesia is defined as a total or partial loss of sensation and it may be general, local or topical, depending on the method of drug administration and area of the body affected.
CALVIERI, Stefano, CANTISANI, CARMEN, D'ANDREA, Vito, Frascani, F, MACALUSO, LAURA, paolino, giovanni, RICHETTA, Antonio Giovanni   +6 more
core   +1 more source

PVNCRF Neurons Regulate Migraine‐Like Allodynia by Activating CRFR2 on Spinal Trigeminal Caudalis Glutamatergic Neurons

Advanced Science, EarlyView.
Paraventricular CRF neurons in the hypothalamus project to glutamatergic neurons of the spinal trigeminal caudal nucleus, enhancing neuronal activation and CRFR2 signaling. This pathway increases CRF release and excitatory drive, promoting central sensitization and migraine‐related behaviors. Targeting the PVN–SP5C circuit provides a potential strategy
Jiang Bian, Xiao‐Long Wang, Li Yin, Wei Wei, Xue Li, Yao Ge, Zhao‐Xia Xiang, Na Tian, Li‐Juan Chen, Ming‐Wei Ma, Xia Zhang, Xu Jing, Mei‐Yun Wang, Xu‐Feng Xu   +13 more
wiley   +1 more source

Artesunate Ameliorates APAP‐induced Liver Injury by Promoting NEDD4L‐Mediated Ubiquitination and Degradation of TXNIP

Advanced Science, EarlyView.
ABSTRACT Liver injury can lead to severe acute liver failure and even death in patients. Artesunate (ART), which is a derivative of artemisinin that has been approved by the FDA for the treatment of malaria, has significant regulatory effects on cell death and inflammation.
Zhe Zhang, Hongyi Zhang, Haixiang Guo, Xiwen Zhang, Yidan Wang, Baoyin Wang, Tong Wang, Guokun Zhao, Qing Zhang, Fei Gao, Shuang Liang, Hao Jiang, Yu Ding, Xiliang Du, Jiabao Zhang, Yi Zheng, Xinwei Li, Bao Yuan   +17 more
wiley   +1 more source

Analgesic effects of adding lidocaine to morphine pumps after orthopedic surgeries

Journal of Research in Medical Sciences, 2014
Background: Opiate is used in patient-controlled intravenous analgesia pumps (PCIA) for controlling pain in post-surgical patients. Other drugs are remarkably added to opioid pumps to enhance quality, lengthen analgesia, and reduce side effects ...
Mahmoud Reza Alebouyeh, Farnad Imani, Poupak Rahimzadeh, Saeed Reza Entezary, Seyed Hamid Reza Faiz, Parisa Soraya   +5 more
doaj  

Patient attitudes towards analgesia and their openness to non-pharmacological methods such as acupuncture in the emergency department [PDF]

, 2018
Aims: To investigate patient attitudes to analgesia, opioids and non-pharmacological analgesia including acupuncture, in the ED. Methods: ED patients with pain were surveyed regarding: pain scores, satisfaction, addiction concern, non-pharmacological ...
Aldridge, Emogene S, Bulsara, Max K, Hince, Dana A, Jan, Andrew L, Rogers, Ian R, Visser, Eric J   +5 more
core   +1 more source