Results 121 to 130 of about 347,788 (376)

Reshape the Fates of Treg and CD8+T Cells Through IL‐2Rα by Synergizing Divergent Receptor‐Biased IL‐2 PEGylates

Advanced Science, EarlyView.
This study presents receptor‐biased IL‐2 PEGylates that selectively modulate IL‐2 receptor subunit interactions to enhance CD8⁺ T cell antitumor activity while curbing Treg activation and endothelial toxicity. The combined not‐α and not‐β variants balance immune stimulation and prevent T cell exhaustion, offering a novel, fine‐tuned approach for ...
Jiaqi Sun, Lingfeng Guo, Dezhong Ji, Mengfan Yu, Boyang Cheng, Xingxing Zhu, Yeshuang Yuan, Siyu Wu, Yuanjie Zhang, Wen Shi, Zhiqian Chen, Xindang Chu, Jiayu Hu, Liwen Hua, Yiming Wang, Yanning Zhu, Yu Mu, Hanwen Sun, Chuanling Zhang, Qi Wang, Sulong Xiao, Lihe Zhang, Bo Zhang, Demin Zhou   +23 more
wiley   +1 more source

GENERAL ANALGESIA BY ORAL ADMINISTRATION [PDF]

, 1918
J. T. Gwathmey, Howard T. Karsner
openalex   +1 more source

Chronic, Battery‐Free, Fully Implantable Multimodal Spinal Cord Stimulator for Pain Modulation in Small Animal Models

Advanced Science, EarlyView.
This work introduces wireless‐powered fully implantable spinal cord stimulation (SCS) in freely moving animal models, supporting diverse ethological paradigms. kHz stimulation with real‐time digital programming offers versatile, dynamically optimized therapy. Scalable fabrication ensures high N studies and seamless translation.
Allie J. Widman, Taron Bashar, Alex Burton, David Marshall Clausen, Prashant Gupta, Drew K. Wolf, Jakayla Folarin‐Hines, Maria Payne, John A Rogers, Kathleen W. Meacham, Robert W. Gereau, Philipp Gutruf   +11 more
wiley   +1 more source

Sixth-Nerve Palsy after Lumbar Puncture and Spinal Analgesia [PDF]

, 1953
A. A.
openalex   +1 more source

The Lung Microbiome Modulates Pain‐Like Behavior Via the Lung–Brain Axis in a Nitroglycerin‐Induced Chronic Migraine Mouse Model

Advanced Science, EarlyView.
Intratracheal neomycin alters pulmonary microbiota, activating the vagus nerve via lung brain‐derived neurotrophic factor/tropomyosin receptor kinase B (BDNF/TrkB) pathway, further projecting to nucleus of solitary tract (NTS), then dorsal raphe nucleus (DRN), where activated serotoninergic neurons increase brain serotonin, alleviating migraine.
Biying Liu, Chengya Huang, Xin Li, Haonan Yu, Yuefeng Xia, Kun Liu, Xingji You, Jingxiang Wu   +7 more
wiley   +1 more source

Patients’ and emergency clinicians’ perceptions of improving pre-hospital pain management: a qualitative study [PDF]

, 2013
Background: The authors aimed to investigate patients' and practitioners' views and experiences of pre-hospital pain management to inform improvements in care and a patient-centred approach to treatment. Methods: This was a qualitative study involving a
Iqbal, Mohammad, Siriwardena, A. Niroshan, Spaight, Anne   +2 more
core   +1 more source

Clinical ethics recommendations for the allocation of intensive care treatments in exceptional, resource-limited circumstances: the Italian perspective during the COVID-19 epidemic

Critical Care, 2020
Marco Vergano, Guido Bertolini, Alberto Giannini, Giuseppe R. Gristina, Sergio Livigni, Giovanni Mistraletti, Luigi Riccioni, Flavia Petrini   +7 more
doaj   +1 more source

S‐ketamine Alleviates Neuroinflammation and Attenuates Lipopolysaccharide‐Induced Depression Via Targeting SIRT2

Advanced Science, EarlyView.
S‐ketamine binds directly to SIRT2, facilitating its interaction with NF‐κB p65. This interaction reduces the acetylation of NF‐κB p65 and inhibits its activation, thereby exerting anti‐inflammatory and antidepressant effects. Created by BioRender.
Cong Lin, Xiaoxuan Zhou, Mingqi Li, Cong Zhang, Haojiang Zhai, Haohong Li, Hongshuang Wang, Xiaohui Wang   +7 more
wiley   +1 more source

Linking pain and the body: neural correlates of visually induced analgesia [PDF]

, 2012
The visual context of seeing the body can reduce the experience of acute pain, producing a multisensory analgesia. Here we investigated the neural correlates of this “visually induced analgesia” using fMRI.
,, Driver, J, Haggard, P, Iannetti, GD, Longo, MR, Mancini, F   +5 more
core   +2 more sources

SOME POINTS REGARDING SPINAL ANALGESIA, WITH A RECORD OF FIFTY CONSECUTIVE CASES. [PDF]

, 1908
J Mill Renton
openalex   +1 more source