7-Hydroxymitragynine Is an Active Metabolite of Mitragynine and a Key Mediator of Its Analgesic Effects [PDF]
ACS Central Science, 2019 Mitragynina speciosa, more commonly known as kratom, is a plant native to Southeast Asia, the leaves of which have been used traditionally as a stimulant, analgesic, and treatment for opioid addiction.
Andrew C Kruegel +2 more
exaly +5 more sources
Trends in Opioid Analgesic Abuse and Mortality in the United States
New England Journal of Medicine, 2015 Richard C Dart, Hilary L Surratt
exaly +2 more sources
Breaking barriers to novel analgesic drug development
Nature Reviews Drug Discovery, 2017 Bruce P Bean, Clifford J Woolf
exaly +2 more sources
Analgesic Effect of Acetaminophen: A Review of Known and Novel Mechanisms of Action
Frontiers in Pharmacology, 2020 Acetaminophen is one of the most commonly used analgesic agents for treating acute and chronic pain. However, its metabolism is complex, and its analgesic mechanisms have not been completely understood.
Nobuko Ohashi, T. Kohno
semanticscholar +1 more source
A review of the mechanism of the central analgesic effect of lidocaine
Medicine, 2020 Lidocaine, as the only local anesthetic approved for intravenous administration in the clinic, can relieve neuropathic pain, hyperalgesia, and complex regional pain syndrome. Intravenous injection of lidocaine during surgery is considered as an effective
Xi Yang +4 more
semanticscholar +1 more source
The Modified WHO Analgesic Ladder: Is It Appropriate for Chronic Non-Cancer Pain?
Journal of Pain Research, 2020 Introduction From 1986, the World Health Organization (WHO) analgesic ladder has been used as the simple and valuable pain-relieving guidance in the pharmaceutical pain management, however, with the development of medical history, notions about pain ...
Juan Yang +4 more
semanticscholar +1 more source
Depressive symptoms are associated with analgesic use in people with Alzheimer's disease: Kuopio ALSOVA study. [PDF]
, 2015 Neuropsychiatric symptoms of Alzheimer's disease (AD) such as depression may be associated with pain, which according to the literature may be inadequately recognized and managed in this population.
ALSOVA Study Group, . +9 more
core +2 more sources
Multimodal Analgesic Regimen for Spine Surgery
Anesthesiology, 2020 Background: Various multimodal analgesic approaches have been proposed for spine surgery. The authors evaluated the effect of using a combination of four nonopioid analgesics versus placebo on Quality of Recovery, postoperative opioid consumption, and ...
K. Maheshwari +13 more
semanticscholar +1 more source
Patterns of analgesic use, pain and self-efficacy: a cross-sectional study of patients attending a hospital rheumatology clinic [PDF]
, 2009 Background: Many people attending rheumatology clinics use analgesics and non-steroidal anti-inflammatories for persistent musculoskeletal pain. Guidelines for pain management recommend regular and pre-emptive use of analgesics to reduce the impact of ...
A Bandura +41 more
core +4 more sources
β‐caryophyllene and β‐caryophyllene oxide—natural compounds of anticancer and analgesic properties
Cancer Medicine, 2016 Natural bicyclic sesquiterpenes, β‐caryophyllene (BCP) and β‐caryophyllene oxide (BCPO), are present in a large number of plants worldwide. Both BCP and BCPO (BCP(O)) possess significant anticancer activities, affecting growth and proliferation of ...
Klaudyna Fidyt +3 more
semanticscholar +1 more source