Results 1 to 10 of about 227,882 (145)

Lawsonia inermis possesses a significant analgesic activity compared to Waltheria indica, Moringa oleifera, Nigella sativa, and diclofenac in female Wistar rats [PDF]

The Iranian Journal of Veterinary Science and Technology, 2023
Pain is a severe symptom of many diseases, with an increasing percentage of people manifesting various types of pain. Medicinal plants provide analgesic potential with little toxicity.
Abdulfatai Aremu, Jiddah Idris, Ganiu Akorede, Aishat Olatumji, Afisu Basiru, Akeem Ahmed   +5 more
doaj   +1 more source

Improvements in Intractable Lumbar and Lower-Extremity Symptoms after Systemic Administration of Tocilizumab, an Anti-interleukin-6 Receptor Antibody [PDF]

Asian Spine Journal, 2022
Study Design Prospective cohort study (open-label, single-arm, and non-blinded). Purpose This study aims to determine the effects of systemic administration of tocilizumab, an anti-interleukin-6 (IL-6) receptor antibody on refractory low back pain and ...
Takeshi Sainoh, Sumihisa Orita, Masayuki Miyagi, Miyako Suzuki-Narita, Yoshihiro Sakuma, Yasuhiro Oikawa, Go Kubota, Jun Sato, Yasuhiro Shiga, Kazuki Fujimoto, Yawara Eguchi, Masao Koda, Yasuchika Aoki, Tsutomu Akazawa, Takeo Furuya, Junichi Nakamura, Hiroshi Takahashi, Satoshi Maki, Masahiro Inoue, Hideyuki Kinoshita, Masaki Norimoto, Takashi Sato, Masashi Sato, Masahiro Suzuki, Keigo Enomoto, Hiromitsu Takaoka, Norichika Mizuki, Takashi Hozumi, Ryuto Tsuchiya, Geundong Kim, Takuma Otagiri, Tomohito Mukaihata, Takahisa Hishiya, Seiji Ohtori, Kazuhide Inage   +34 more
doaj   +1 more source

Spiral Computed Tomography with Phytocomposition as a Diagnostic Tool for Adhesive Intestinal Obstruction [PDF]

Journal of Biomedical Physics and Engineering, 2020
Background: Adhesive intestinal obstruction is a common and potentially lethal complication after surgical interventions in the abdomen. Radiologic imaging is the main diagnostic method.
F Mufazalov, I Sufiyarov, A Hasanov, G Yamalova, E Bakirov, A Samorodov   +5 more
doaj   +1 more source

Bulleyaconitine A reduces fracture-induced pain and promotes fracture healing in mice

Frontiers in Pharmacology, 2023
A fracture is a severe trauma that causes dramatic pain. Appropriate fracture pain management not only improves the patient’s subjective perception, but also increases compliance with rehabilitation training. However, current analgesics for fracture pain
Jun Peng, Sheng Xiao, Juan Xie, Wan Fu
doaj   +1 more source

NSAIDs Naproxen, Ibuprofen, Salicylate, and Aspirin Inhibit TRPM7 Channels by Cytosolic Acidification

Frontiers in Physiology, 2021
Non-steroidal anti-inflammatory drugs (NSAIDs) are used for relieving pain and inflammation accompanying numerous disease states. The primary therapeutic mechanism of these widely used drugs is the inhibition of cyclooxygenase 1 and 2 (COX1, 2) enzymes ...
Rikki Chokshi, Orville Bennett, Tetyana Zhelay, J. Ashot Kozak   +3 more
doaj   +1 more source

Expect analgesic failure; pursue analgesic success [PDF]

BMJ, 2013
Most analgesic drugs work well but in only a small percentage of people. Andrew Moore and colleagues argue that we need to move away from a focus on average response and seek out what works for each ...
Moore, Andrew, Derry, Sheena, Eccleston, Christopher, Kalso, Eija   +3 more
openaire   +4 more sources

Design and Synthesis In Silico Drug-like Prediction and Pharmacological Evaluation of Cyclopolymethylenic Homologous of LASSBio-1514

Molecules, 2021
Acylhydrazones are still an important framework to the design of new bioactive compounds. As treatment of chronic pain represents a clinical challenge, we decided to modify the structure of LASSBio-1514 (1), previously described as anti-inflammatory and ...
Lidia Moreira Lima, Tiago Fernandes da Silva, Carlos Eduardo da Silva Monteiro, Cristiane Aparecida-Silva, Walfrido Bispo Júnior, Aline Cavalcanti de Queiroz, Magna Suzana Alexandre-Moreira, Gisele Zapata-Sudo, Eliezer J. Barreiro   +8 more
doaj   +1 more source

Correction to: Pathophysiologic Approach to Pain Therapy for Complex Pain Entities: A Narrative Review

Pain and Therapy, 2020
Figure 1 caption was processed and published incorrectly. The correct caption should read as follows:
Martina Rekatsina, Antonella Paladini, Alba Piroli, Panagiotis Zis, Joseph V. Pergolizzi, Giustino Varrassi   +5 more
doaj   +1 more source

Evaluation of the Intracellular Signaling Activities of κ-Opioid Receptor Agonists, Nalfurafine Analogs; Focusing on the Selectivity of G-Protein- and β-Arrestin-Mediated Pathways

Molecules, 2022
Opioid receptors (ORs) are classified into three types (μ, δ, and κ), and opioid analgesics are mainly mediated by μOR activation; however, their use is sometimes restricted by unfavorable effects.
Masahiro Yamaguchi, Kanako Miyano, Shigeto Hirayama, Yusuke Karasawa, Kaori Ohshima, Eiko Uezono, Akane Komatsu, Miki Nonaka, Hideaki Fujii, Keisuke Yamaguchi, Masako Iseki, Masakazu Hayashida, Yasuhito Uezono   +12 more
doaj   +1 more source

Analgesic and Anti-Arthritic Activities of Polysaccharides in Chaenomeles speciosa

Frontiers in Pharmacology, 2022
Chaenomeles speciosa (Sweet) Nakai has been long used as a folk medicine for rheumatic diseases treatment. This study aimed to investigate the effects and underlying mechanism of polysaccharides in Chaenomeles speciosa (CSP) on the pro-inflammatory ...
Doudou Huang, Doudou Huang, Shenggui Jiang, Zenan Du, Yanhong Chen, Dan Xue, Xiujuan Wang, Mengshuang Li, Feng Zhang, Wansheng Chen, Wansheng Chen, Lianna Sun   +11 more
doaj   +1 more source