7‑hydroxymitragynine is an active metabolite of mitragynine and a key mediator of its analgesic effects [PDF]
ACS Central Science, 2019 Mitragynina speciosa, more commonly known as kratom, is a plant native to Southeast Asia, the leaves of which have been used traditionally as a stimulant, analgesic, and treatment for opioid addiction.
Ansonoff, Michael +12 more
core +4 more sources
Lawsonia inermis possesses a significant analgesic activity compared to Waltheria indica, Moringa oleifera, Nigella sativa, and diclofenac in female Wistar rats [PDF]
The Iranian Journal of Veterinary Science and Technology, 2023 Pain is a severe symptom of many diseases, with an increasing percentage of people manifesting various types of pain. Medicinal plants provide analgesic potential with little toxicity.
Abdulfatai Aremu +5 more
doaj +1 more source
Improvements in Intractable Lumbar and Lower-Extremity Symptoms after Systemic Administration of Tocilizumab, an Anti-interleukin-6 Receptor Antibody [PDF]
Asian Spine Journal, 2022 Study Design Prospective cohort study (open-label, single-arm, and non-blinded). Purpose This study aims to determine the effects of systemic administration of tocilizumab, an anti-interleukin-6 (IL-6) receptor antibody on refractory low back pain and ...
Takeshi Sainoh +34 more
doaj +1 more source
Spiral Computed Tomography with Phytocomposition as a Diagnostic Tool for Adhesive Intestinal Obstruction [PDF]
Journal of Biomedical Physics and Engineering, 2020 Background: Adhesive intestinal obstruction is a common and potentially lethal complication after surgical interventions in the abdomen. Radiologic imaging is the main diagnostic method.
F Mufazalov +5 more
doaj +1 more source
Bulleyaconitine A reduces fracture-induced pain and promotes fracture healing in mice
Frontiers in Pharmacology, 2023 A fracture is a severe trauma that causes dramatic pain. Appropriate fracture pain management not only improves the patient’s subjective perception, but also increases compliance with rehabilitation training. However, current analgesics for fracture pain
Jun Peng, Sheng Xiao, Juan Xie, Wan Fu
doaj +1 more source
Frontiers in Physiology, 2021 Non-steroidal anti-inflammatory drugs (NSAIDs) are used for relieving pain and inflammation accompanying numerous disease states. The primary therapeutic mechanism of these widely used drugs is the inhibition of cyclooxygenase 1 and 2 (COX1, 2) enzymes ...
Rikki Chokshi +3 more
doaj +1 more source
Analgesic Effect of Acetaminophen: A Review of Known and Novel Mechanisms of Action
Frontiers in Pharmacology, 2020 Acetaminophen is one of the most commonly used analgesic agents for treating acute and chronic pain. However, its metabolism is complex, and its analgesic mechanisms have not been completely understood.
Nobuko Ohashi, T. Kohno
semanticscholar +1 more source
Pain and Therapy, 2020 Figure 1 caption was processed and published incorrectly. The correct caption should read as follows:
Martina Rekatsina +5 more
doaj +1 more source
Molecules, 2021 Acylhydrazones are still an important framework to the design of new bioactive compounds. As treatment of chronic pain represents a clinical challenge, we decided to modify the structure of LASSBio-1514 (1), previously described as anti-inflammatory and ...
Lidia Moreira Lima +8 more
doaj +1 more source
Pathophysiologic Approach to Pain Therapy for Complex Pain Entities: A Narrative Review
Pain and Therapy, 2020 Pain management is challenging for both clinicians and patients. In fact, pain patients are frequently undertreated or even completely untreated. Optimal treatment is based on targeting the underlying mechanisms of pain and tailoring the management ...
Martina Rekatsina +5 more
doaj +1 more source