Results 121 to 130 of about 353,256 (314)

Synthesis of silver and gold nanoparticles from leaf of Litchi chinensis and its biological activities

Asian Pacific Journal of Tropical Biomedicine, 2018
Objective: To synthesize and isolate silver and gold nanoparticles from Litchi chinensis leaf methanolic extract, and to evaluate its comparative biological activities including muscles relaxant, analgesic, anti-inflammatory and antidiarrheal.
Uzma Murad, Barkatullah, Shafqat Ali Khan, Muhammad Ibrar, Sami Ullah, Umbreen Khattak   +5 more
doaj   +1 more source

Time to take stock: a meta-analysis and systematic review of analgesic treatment disparities for pain in the United States.

Pain medicine (Malden, Mass.), 2012
BACKGROUND The recent Institute of Medicine Report assessing the state of pain care in the United States acknowledged the lack of consistent data to describe the nature and magnitude of unrelieved pain and identify subpopulations with disproportionate ...
S. Meghani, Eeeseung Byun, R. Gallagher
semanticscholar   +1 more source

The Lung Microbiome Modulates Pain‐Like Behavior Via the Lung–Brain Axis in a Nitroglycerin‐Induced Chronic Migraine Mouse Model

Advanced Science, EarlyView.
Intratracheal neomycin alters pulmonary microbiota, activating the vagus nerve via lung brain‐derived neurotrophic factor/tropomyosin receptor kinase B (BDNF/TrkB) pathway, further projecting to nucleus of solitary tract (NTS), then dorsal raphe nucleus (DRN), where activated serotoninergic neurons increase brain serotonin, alleviating migraine.
Biying Liu, Chengya Huang, Xin Li, Haonan Yu, Yuefeng Xia, Kun Liu, Xingji You, Jingxiang Wu   +7 more
wiley   +1 more source

The clinical analgesic efficacy of buprenorphine

Journal of Clinical Pharmacy and Therapeutics, 2014
Based on in vitro assays and select animal models, buprenorphine is commonly called a ‘partial agonist’. An implication is that it should produce less analgesic effect in humans than so‐called ‘full agonists’ such as morphine or fentanyl.
Robert B. Raffa, M. Haidery, H. M. Huang, K. Kalladeen, D. Lockstein, H. Ono, M. Shope, O. A. Sowunmi, J. K. Tran, Joseph V. Pergolizzi, Joseph V. Pergolizzi, Joseph V. Pergolizzi   +11 more
semanticscholar   +1 more source

Multilineage-differentiating stress-enduring cells alleviate neuropathic pain in mice by secreting TGF-b and IL-10 [PDF]

arXiv
Neuropathic pain is a chronic condition characterized by damage to and dysfunction of the peripheral or central nervous system. There are currently no effective treatment options available for neuropathic pain, and existing drugs often provide only temporary relief with potential side effects.
arxiv  

S‐ketamine Alleviates Neuroinflammation and Attenuates Lipopolysaccharide‐Induced Depression Via Targeting SIRT2

Advanced Science, EarlyView.
S‐ketamine binds directly to SIRT2, facilitating its interaction with NF‐κB p65. This interaction reduces the acetylation of NF‐κB p65 and inhibits its activation, thereby exerting anti‐inflammatory and antidepressant effects. Created by BioRender.
Cong Lin, Xiaoxuan Zhou, Mingqi Li, Cong Zhang, Haojiang Zhai, Haohong Li, Hongshuang Wang, Xiaohui Wang   +7 more
wiley   +1 more source

COMPARATIVE EFFICACY (SEDATIVE AND ANAESTHETIC) OF DETOMIDINE, KETAMINE AND DETOMIDINE-KETAMINE COCKTAIL IN PIGEONS (COLUMBA LIVIA) [PDF]

Pakistan Veterinary Journal, 2008
A study was conducted to compare the synergistic efficacy of detomidine, ketamine and their cocktail in pigeons (Columba livia). For this study, 15 adult and healthy pigeons were divided into three equal groups A, B and C.
UZMA F. DURRANI, M. ARIF KHAN1 AND S. SALEEM AHMAD
doaj  

Pia Mater‐Penetrable Lipopolymer Nanoparticles for Gliocyte‐Targeted IL‐10 mRNA Therapy Alleviate Paclitaxel‐Induced Peripheral Neuropathy

Advanced Science, EarlyView.
The P6CIT lipopolymer demonstrates superior transfection efficacy in the spinal cord and DRG, as well as enhanced penetration of the pia mater compared to the MC3 ionizable lipid. Intrathecal delivery of P6CIT LPNPs enables effective transfection in the gliocytes in the spinal cord and DRG.
Xinrou Lin, Lingyu Wei, Xiangpen Li, Ling Zeng, Yingsen Tang, Hongjin Wang, Hengjian Lu, Chenguang Li, Hongxuan Wang, Jinjin Chen, Ying Peng   +10 more
wiley   +1 more source

Editorial: Verification of Animal Pain Models by Reverse Translation

Frontiers in Pharmacology, 2021
Robert M. Caudle, Maree Therese Smith, E. Alfonso Romero-Sandoval   +2 more
doaj   +1 more source

Pooled safety analysis of diclofenac sodium topical solution 1.5% (w/w) in the treatment of osteoarthritis in patients aged 75 years or older

Clinical Interventions in Aging, 2012
Sanford H Roth1, Philip Fuller21Arizona Research and Education, Phoenix, AZ, 2Medical Affairs, Mallinckrodt Inc, Hazelwood, MOBackground: This study aimed to determine the safety of diclofenac sodium topical solution 1.5% (w/w) in 45.5% dimethyl ...
Roth SH, Fuller P
doaj