Results 131 to 140 of about 328,147 (311)

EphB1 Receptor Blockade Augments Morphine Antinociception via Inhibiting GRK2‐Mediated µ‐Opioid Receptor Internalization

open access: yesAdvanced Science, EarlyView.
Administration of opioids activates ephrinB2‐EphB1 receptor signaling. Activated EphB1 receptors induce GRK2‐mediated phosphorylation of MOR at Ser375, which initiates the internalization of MOR and reduces opioid antinociception at the behavioral level. ABSTRACT Opioids are the primary treatment for severe pain in clinical practice.
Bo Peng   +7 more
wiley   +1 more source

The analgesic evaluation of an opioid-free anaesthesia protocol in cats undergoing ovariectomy

open access: yes
Opioid-free protocols are increasingly used in veterinary medicine although there are few studies concerning the feline species. In 2022, Rufiange et al.
Andrea Paolini   +2 more
core  

THE ANALGESIC EFFECTS OF CHENOPODIUM AMBROSIOIDES

open access: yes, 2002
Aqueous extract of the leaf of Chenopodium ambrosides, a Nigeria traditional medicinal plant, has been evaluated for its analgesic potential in mice. The analgesic potential of the plant extract was studied using the thermal (hot plate) test.
Yusuf, O.G.   +3 more
core   +1 more source

Engineering Spatially Localized Bioactive Microenvironments in Assembly Implants for Spatially Extended Bone Ingrowth

open access: yesAdvanced Science, EarlyView.
An assembly porous titanium/β‐TCP implant is developed to establish a spatially programmable osteogenic microenvironment for enhanced osseointegration. By decoupling mechanical support from bioactive ion release, localized ionic gradients generated from the β‐TCP module direct osteogenic activity and bone ingrowth toward the porous titanium framework ...
Heng Zhang   +5 more
wiley   +1 more source

Analgesic and antiinflammatory effects of some 2-mercaptobenzoxazole derivatives

open access: yes, 1996
Analgesic and antiinflammatory effects of benzoxazole derivatives have been investigated in mice. In the acetic acid induced writhing test, the analgesic effect of two compounds were found to be stronger than that of diclofenac sodium.
Vural, K, Erol, K, Safak, C, Simsek, R
core   +2 more sources

Analgesic Effect of Ethanol Extract of Dillenia ochreata (Miq.) Teijsm. & Binn. Ex Martelli in Wistar Rats [PDF]

open access: yes
Dillenia ochreata is a traditional medicine used to treat wounds and scabies. In wound healing, one of the treatments is to reduce pain (analgesic). Some compounds of triterpenoid groups have been known to be active as analgesic compounds. The leaf of D.
Muharni, Muharni   +3 more
core   +1 more source

A Hypothalamic Oxytocinergic–Sympathetic Axis Couples Anxiety Dysregulation With Impaired Tendon–Bone Repair

open access: yesAdvanced Science, EarlyView.
RCI is associated with functional suppression of oxytocinergic neurons in the PVN. Reduced PVNOXT neuronal activity contributes to altered sympathetic regulation involving the IML–sympathetic chain pathway, accompanied by changes in norepinephrine signaling at the BTI.
Liyang Wan   +8 more
wiley   +1 more source

RBMS1 Contributes to Early Arteriovenous Fistula Neointimal Remodeling Through Modulation of VSMC Phenotypic Responses

open access: yesAdvanced Science, EarlyView.
Postoperative arteriovenous fistulas exhibit increased RBMS1 in vascular smooth muscle cells (VSMCs). In experimental AVFs, RBMS1 overexpression aggravates, whereas deletion attenuates, neointimal hyperplasia. RBMS1 binds MPZL1 mRNA and promotes exon 5 skipping to generate MPZL1‐Δ5, which interacts with G3BP1 to activate AKT, driving VSMC proliferation,
Zongda Li   +14 more
wiley   +1 more source

Analgesic effect of Rowapraxin (BR-18) in urological diseases [PDF]

open access: yes, 1971
ROWAPRAXIN (BR-18), a newly developed analgesic of Rowa-Wagner Co., was administered to 28 patients complaining of various type of pain. They were 19 patients of upper urinary diseases, 5 patients after retrograde pyelography, and 4 patients of lower ...
寺杣, 一徳, 高橋, 靖昌
core  

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