Results 121 to 130 of about 328,147 (311)
Diurnal changes in analgesic requirement
, 1999 The aim of this study was to find out 24 hour profile of epidural analgesic requirement of postoperative patients retrospectively. Epidural analgesia records of ASA I-II, 20-60 years old, 192 patients who had lumber epidural catheters placed ...
core
Innovative Approach Reveals How Receptors Control G Protein State Equilibria
Advanced Science, EarlyView.Using conformational specific trFRET biosensors of the Gi protein (depicted at the bottom), the authors show that receptor activation can not only release GDP from the inactive G protein, but can also release GTP from the activated G protein, leading to the reformation of the RG ternary complex.
Alexandre Bouyssou +12 more
wiley +1 more source
Advanced Science, EarlyView.AI‐enabled de novo design of a TREM1 binder, integrated into a BBB‐crossing and macrophage‐targeted nanoplatform, enables TREM1 degradation and attenuates neuroinflammation, thereby promoting neuroprotection and tissue repair after traumatic brain injury. ABSTRACT Secondary neuroinflammation drives progressive damage after traumatic brain injury (TBI),
Yimin Huang +19 more
wiley +1 more source
Advanced Science, EarlyView.Atomically dispersed Fe regulates the local electronic environment and surface properties of SnS, while PMS preferentially coordinates to Sn through Sn–O interaction. Fe incorporation further enhances the Sn–OPMS interfacial interaction, facilitating Sn‐centered PMS activation and the generation of SO4•−/•OH for APAP degradation, thereby clarifying the
Shuhui Liu +5 more
wiley +1 more source
Advanced Science, EarlyView.This study reports a neutrophil membrane‐encapsulated Pd/hCeO2 nanozyme (PCN) for targeted treatment of perioperative neurocognitive disorders (PND) in aged mice. PCN inhibits glycolysis‐driven microglial activation and neuroinflammation, improves mitochondrial respiration, and maintains blood‐brain barrier integrity and synaptic function, ultimately ...
Lili Huang +17 more
wiley +1 more source
Analgesic dipeptide derivatives.
, 2009 The syntheses of dipeptide derivatives of the general formula X-Trp(Nps)-OR (R = H or Me; X = Lys, Gly, Ala, Leu, Ser, Glu, His, Arg, Orn, Dpr, Gpr and Har) are described. The analgesic activities of Gpr- and Har-containing dipeptides have been evaluated
Herranz, Rosario +9 more
core +1 more source
Advanced Science, EarlyView.Lactate accumulation after SCI promotes H4K12la lactylation, which upregulates NDUFS7, triggering mitochondrial RET and ROS, enforcing pro‐inflammatory microglial polarization. MM@mPTC, a biomimetic nanotherapeutic, degrades LDHA in activated microglia, reducing H4K12la lactylation and blocking RET, thus curbing ROS, fostering a reparative phenotype ...
Chenglong Hong +13 more
wiley +1 more source
Advanced Science, EarlyView.Synovial macrophages in osteoarthritis upregulate LSP1, which directly binds and inhibits SOD1, triggering a redox imbalance that activates both NOX and mitochondrial ROS pathways. This cascade drives the release of macrophage extracellular traps (METs), causing chondrocyte damage and disease progression.
Yankai Pan +9 more
wiley +1 more source