Results 131 to 140 of about 583,318 (388)

Discovery of Natural Compound α‐Hederin via Large‐Scale Screening as a Targeted JAK/STAT3 Inhibitor for Ovarian Cancer Therapy

Advanced Science, EarlyView.
This study identifies α‐Hederin as a potent dual JAK1/JAK2 inhibitor that blocks STAT3 activation in ovarian cancer. By disrupting STAT3‐driven transcriptional programs, α‐Hederin suppresses tumor proliferation, invasion, and EMT, while enhancing cisplatin efficacy and overcoming chemoresistance.
Jiayu Wang, Pengzhan He, Cheng Liu, Xin Chen, Yilin Tan, Rui Qu, Yan Zhang, Zhou Li, Tailang Yin, Zhinang Yin   +9 more
wiley   +1 more source

Anti-inflammatory and analgesic activities of the aqueous extracts of Margaritaria discoidea (Euphorbiaceae) stem bark in experimental animal models

Revista de Biología Tropical, 2009
Margaritaria discoidea is a medicinal plant used for the treatment of various body pains in Central, Eastern and Southern Africa. The aqueous extract of its stem bark was investigated for its anti-inflammatory and analgesic activities in animal models ...
Adeolu A Adedapo, Margaret O Sofidiya, Anthony J Afolayan   +2 more
doaj  

Synthesis of silver and gold nanoparticles from leaf of Litchi chinensis and its biological activities

Asian Pacific Journal of Tropical Biomedicine, 2018
Objective: To synthesize and isolate silver and gold nanoparticles from Litchi chinensis leaf methanolic extract, and to evaluate its comparative biological activities including muscles relaxant, analgesic, anti-inflammatory and antidiarrheal.
Uzma Murad, Barkatullah, Shafqat Ali Khan, Muhammad Ibrar, Sami Ullah, Umbreen Khattak   +5 more
doaj   +1 more source

Evaluation of Analgesic Activity of the Methanol Extract from the Galls of Quercus infectoria (Olivier) in Rats

Evidence-Based Complementary and Alternative Medicine, 2014
The present study aims to investigate the analgesic activity of the methanol extract of the galls of Quercus infectoria in rats using hot plate and tail-flick methods.
S. Fan, N. A. Ali, D. F. Basri
semanticscholar   +1 more source

Local anaesthesia efficacy as postoperative analgesia for open shoulder instability surgery. a prospective randomised controlled study [PDF]

, 2012
Background and objectives: The aim of present study was to evaluate for the first time, the clinical effect of local anaesthetic infiltration as postoperative analgesia in open shoulder surgery for anterior-inferior instability.
Caricati Alessio, Costantini Alberto, De Vita Andrea, Di Donato A, Fontana Costantino, Lancia Fabrizio, Rocco Monica   +6 more
core   +1 more source

Analgesic strategies

South African Family Practice, 2014
No abstract available.
openaire   +3 more sources

Calcitonin Gene‐Related Peptide (CGRP)‐Expressing Neurons in the External Lateral Parabrachial Area Regulate Pain‐Induced Sleep Disturbances

Advanced Science, EarlyView.
Lynch et al., identified novel targets on the wake‐promoting pathways that can effectively treat pain‐induced sleep disturbances. The authors demonstrated that Calcitonin gene‐related peptide‐expressing neurons (CGRP) in the external lateral parabrachial nucleus (PBelCGRP) serve as the primary relay node for pain stimuli that cause sleep disruption ...
Nicole Lynch, Roberto De Luca, Richard L Spinieli, Enrico Rillosi, Renner C Thomas, Samuel Sailesh, Nishta Gangeddula, Janayna D Lima, Sathyajit S Bandaru, Elda Arrigoni, Agustin Melo‐Carrillo, Rami Burstein, Stephen Thankachan, Satvinder Kaur   +13 more
wiley   +1 more source

A look inside the association codeine-paracetamol: clinical pharmacology supports analgesic efficacy [PDF]

, 2015
Acute and chronic pain often requires a multimodal approach. Combination therapy reduces the number of individual daily administrations and improves patient's compliance with the prescribed analgesic treatment. Despite the association codeine/paracetamol
COLUZZI, FLAMINIA, MATTIA, Consalvo
core  

Bionic Microneedle Patch Inspired by Drosophila Tarsal Paws Boosts Healing in Bacterial Infectious Stomatitis

Advanced Science, EarlyView.
Microneedle suction cup patches, prepared using bionic Drosophila tarsal claws, can effectively treat bacterial infectious stomatitis by rapidly and efficiently leveraging multiple effects, including antibacterial and anti‐inflammatory properties, promotion of vasodilation, and active mechanical contraction of the wound.
Jiaqi Qin, Cewen Hu, Xiaohong Ran, Huajing Zeng, Jie Zhang, Bin Liu, Zengjie Fan   +6 more
wiley   +1 more source

COMPARATIVE EFFICACY (SEDATIVE AND ANAESTHETIC) OF DETOMIDINE, KETAMINE AND DETOMIDINE-KETAMINE COCKTAIL IN PIGEONS (COLUMBA LIVIA) [PDF]

Pakistan Veterinary Journal, 2008
A study was conducted to compare the synergistic efficacy of detomidine, ketamine and their cocktail in pigeons (Columba livia). For this study, 15 adult and healthy pigeons were divided into three equal groups A, B and C.
UZMA F. DURRANI, M. ARIF KHAN1 AND S. SALEEM AHMAD
doaj