Pharmacogenetics of analgesic drugs [PDF]
, 2013 • Individual variability in pain perception and differences in the efficacy of analgesic drugs are complex phenomena and are partly genetically predetermined.
Branford, R +4 more
core +1 more source
Analgesic prescribing trends in a national sample of older veterans with osteoarthritis: 2012-2017 [PDF]
, 2019 Few investigations examine patterns of opioid and nonopioid analgesic prescribing and concurrent pain intensity ratings before and after institution of safer prescribing programs such as the October 2013 Veterans Health Administration system-wide Opioid ...
Bair, Matthew J. +7 more
core +1 more source
Analgesic efficacy of local infiltration analgesia in hip and knee arthroplasty: a systematic review
British Journal of Anaesthesia, 2014 Henrik Kehlet
exaly +2 more sources
Fractional order impedance models as rising tools for quantification of unconscious analgesia [PDF]
, 2013 This research focuses on modeling the diffusion process that occurs in the human body when an analgesic drug is taken up, by using fractional-order impedance models (FOIMs).
Chevalier, Amélie +3 more
core +1 more source
Analgesic effectiveness and tolerability of oral oxycodone/naloxone and pregabalin in patients with lung cancer and neuropathic pain. An observational analysis [PDF]
, 2016 INTRODUCTION: Cancer-related pain has a severe negative impact on quality of life. Combination analgesic therapy with oxycodone and pregabalin is effective for treating neuropathic cancer pain.
Borghesi, Cristina +6 more
core +2 more sources
Pain outcomes in patients with bone metastases from advanced cancer: assessment and management with bone-targeting agents [PDF]
, 2014 Bone metastases in advanced cancer frequently cause painful complications that impair patient physical activity and negatively affect quality of life. Pain is often underreported and poorly managed in these patients.
A Kretzschmar +69 more
core +1 more source
Cognitive impairment induced by delta9-tetrahydrocannabinol occurs through heteromers between cannabinoid CB1 and serotonin 5-HT2A receptors [PDF]
, 2015 Delta-9-tetrahydrocannabinol (THC), the main psychoactive compound of marijuana, induces numerous undesirable effects, including memory impairments, anxiety, and dependence.
A Busquets-Garcia +112 more
core +5 more sources
Analgesic Mechanisms of Antidepressants for Neuropathic Pain
International Journal of Molecular Sciences, 2017 Tricyclic antidepressants and serotonin noradrenaline reuptake inhibitors are used to treat chronic pain, such as neuropathic pain. Why antidepressants are effective for treatment of neuropathic pain and the precise mechanisms underlying their effects ...
H. Obata
semanticscholar +1 more source
Analgesia induced by the epigenetic drug, L-acetylcarnitine, outlasts the end of treatment in mouse models of chronic inflammatory and neuropathic pain [PDF]
, 2017 Background: L-acetylcarnitine, a drug marketed for the treatment of chronic pain, causes analgesia by epigenetically up-regulating type-2 metabotropic glutamate (mGlu2) receptors in the spinal cord.
Battaglia, Giuseppe +10 more
core +1 more source
Frontiers in Pharmacology, 2019 Despite the progress that has occurred in recent years in the development of therapies to treat painful and inflammatory diseases, there is still a need for effective and potent analgesics and anti-inflammatory drugs.
L. Staurengo-Ferrari +6 more
semanticscholar +1 more source