Results 11 to 20 of about 644,703 (404)

Analgesic Effect of Acetaminophen: A Review of Known and Novel Mechanisms of Action

Frontiers in Pharmacology, 2020
Acetaminophen is one of the most commonly used analgesic agents for treating acute and chronic pain. However, its metabolism is complex, and its analgesic mechanisms have not been completely understood.
Nobuko Ohashi, T. Kohno
semanticscholar   +1 more source

The Modified WHO Analgesic Ladder: Is It Appropriate for Chronic Non-Cancer Pain?

Journal of Pain Research, 2020
Introduction From 1986, the World Health Organization (WHO) analgesic ladder has been used as the simple and valuable pain-relieving guidance in the pharmaceutical pain management, however, with the development of medical history, notions about pain ...
Juan Yang, B. Bauer, D. Wahner-Roedler, T. Chon, Lizu Xiao   +4 more
semanticscholar   +1 more source

A review of the mechanism of the central analgesic effect of lidocaine

Medicine, 2020
Lidocaine, as the only local anesthetic approved for intravenous administration in the clinic, can relieve neuropathic pain, hyperalgesia, and complex regional pain syndrome. Intravenous injection of lidocaine during surgery is considered as an effective
Xi Yang, Xinchuan Wei, Yi Mu, Qian Li, Jin Liu   +4 more
semanticscholar   +1 more source

Evaluation of the Intracellular Signaling Activities of κ-Opioid Receptor Agonists, Nalfurafine Analogs; Focusing on the Selectivity of G-Protein- and β-Arrestin-Mediated Pathways

Molecules, 2022
Opioid receptors (ORs) are classified into three types (μ, δ, and κ), and opioid analgesics are mainly mediated by μOR activation; however, their use is sometimes restricted by unfavorable effects.
Masahiro Yamaguchi, Kanako Miyano, Shigeto Hirayama, Yusuke Karasawa, Kaori Ohshima, Eiko Uezono, Akane Komatsu, Miki Nonaka, Hideaki Fujii, Keisuke Yamaguchi, Masako Iseki, Masakazu Hayashida, Yasuhito Uezono   +12 more
doaj   +1 more source

Multimodal Analgesic Regimen for Spine Surgery

Anesthesiology, 2020
Background: Various multimodal analgesic approaches have been proposed for spine surgery. The authors evaluated the effect of using a combination of four nonopioid analgesics versus placebo on Quality of Recovery, postoperative opioid consumption, and ...
K. Maheshwari, R. Avitsian, D. Sessler, N. Makarova, M. Tanios, S. Raza, D. Traul, S. Rajan, Mariel Manlapaz, Sandra Machado, A. Krishnaney, A. Machado, R. Rosenquist, A. Kurz   +13 more
semanticscholar   +1 more source

Depressive symptoms are associated with analgesic use in people with Alzheimer's disease: Kuopio ALSOVA study. [PDF]

, 2015
Neuropsychiatric symptoms of Alzheimer's disease (AD) such as depression may be associated with pain, which according to the literature may be inadequately recognized and managed in this population.
ALSOVA Study Group, ., Bell, JS, Gilmartin, JF, Hallikainen, I, Koivisto, AM, Lönnroos, E, Martikainen, J, Salo, L, Törmälehto, S, Väätäinen, S   +9 more
core   +2 more sources

Patterns of analgesic use, pain and self-efficacy: a cross-sectional study of patients attending a hospital rheumatology clinic [PDF]

, 2009
Background: Many people attending rheumatology clinics use analgesics and non-steroidal anti-inflammatories for persistent musculoskeletal pain. Guidelines for pain management recommend regular and pre-emptive use of analgesics to reduce the impact of ...
A Bandura, AL Harrison, D Berry, E Kalso, F Viller, F Wolfe, FJ Keefe, G Rose, H Brus, J Dowell, J Feinglass, J Fifield, JA Turner, JEM Sale, JR Kirwan, K Lorig, Kate Jolly, LI Aljasem, LR Harrold, M Brekke, M Gustafsson, M Hale, MA Rapoff, MJ Cross, N Barber, NC Beck, NT James, Paresh Jobanputra, R Neame, R Tuncay, RH Straub, Ruth Blamey, S McConnell, S Newman, S Wilcox, SE Ward, SH Saydah, Sheila Greenfield, SM Edworthy, TR Allison, W Katon, YH Lai   +41 more
core   +4 more sources

Does Erector Spinae Plane Block Have a Visceral Analgesic Effect?: A Randomized Controlled Trial

Scientific Reports, 2020
The visceral analgesic efficacy of erector spinae plane block (ESPB) is still a matter of debate. This study attempted to investigate the visceral analgesic efficacy of ESPB in clinical setting.
Hye-Mee Kwon, Doo-Hwan Kim, S. Jeong, Kyu‐Taek Choi, Sooin Park, Hyun-Jung Kwon, Jong-Hyuk Lee   +6 more
semanticscholar   +1 more source

Analgesic and Anti-Arthritic Activities of Polysaccharides in Chaenomeles speciosa

Frontiers in Pharmacology, 2022
Chaenomeles speciosa (Sweet) Nakai has been long used as a folk medicine for rheumatic diseases treatment. This study aimed to investigate the effects and underlying mechanism of polysaccharides in Chaenomeles speciosa (CSP) on the pro-inflammatory ...
Doudou Huang, Doudou Huang, Shenggui Jiang, Zenan Du, Yanhong Chen, Dan Xue, Xiujuan Wang, Mengshuang Li, Feng Zhang, Wansheng Chen, Wansheng Chen, Lianna Sun   +11 more
doaj   +1 more source

Oral application of magnesium‐L‐threonate enhances analgesia and reduces the dosage of opioids needed in advanced cancer patients—A randomized, double‐blind, placebo‐controlled trial

Cancer Medicine, 2023
Purpose To investigate the effects of oral administration of magnesium‐L‐threonate, a novel magnesium compound, on the analgesic effect of opioids in patients with advanced cancer.
Siyin Wu, Tian Jin, Bingjie Ma, Yun Ji, Xuehua Huang, Peiliang Wang, Xiaoming Liu, Boris V. Krylov, Xianguo Liu, Ke Ma   +9 more
doaj   +1 more source