A plug-and-play type field-deployable bio-agent free salicylic acid sensing system [PDF]
Salicylic acid (SA) is a primary phytohormone released in response to stress, particularly biotic infections in plants. Monitoring SA levels may provide a way for early disease detection in crops providing a way for applying effective measures for reducing agricultural losses while increase our agricultural efficiency.
arxiv
Process Design and Economics of Production of p-Aminophenol [PDF]
Para-Aminophenol is one of the key chemicals required for the synthesis of Paracetamol, an analgesic and antipyretic drug. Data shows a large fraction of India's demand for Para-Aminophenol being met through imports from China. The uncertainty in the India-China relations would affect the supply and price of this "Key Starting Material." This report is
arxiv
Pain and Physical Activity Association in Critically Ill Patients [PDF]
Critical care patients experience varying levels of pain during their stay in the intensive care unit, often requiring administration of analgesics and sedation. Such medications generally exacerbate the already sedentary physical activity profiles of critical care patients, contributing to delayed recovery.
arxiv
Paracetamol Micro-Structure Analysis by Optical Mapping [PDF]
Domain structure of paracetamol -- popular antipyretic analgesic -- was investigated by infrared (IR) spectroscopy using synchrotron radiation. Absorbance and retardance maps reveal molecular orientation inside the micro-domains of the paracetamol form II which has a better water solubility and compressibility compared to the commercially used forms I.
arxiv +1 more source
Investigating Dissemination of Scientific Information on Twitter: A Study of Topic Networks in Opioid Publications [PDF]
One way to assess a certain aspect of the value of scientific research is to measure the attention it receives on social media. While previous research has mostly focused on the "number of mentions" of scientific research on social media, the current study applies "topic networks" to measure public attention to scientific research on Twitter.
arxiv
Individualized Risk Assessment of Preoperative Opioid Use by Interpretable Neural Network Regression [PDF]
Preoperative opioid use has been reported to be associated with higher preoperative opioid demand, worse postoperative outcomes, and increased postoperative healthcare utilization and expenditures. Understanding the risk of preoperative opioid use helps establish patient-centered pain management.
arxiv
Improving Opioid Use Disorder Risk Modelling through Behavioral and Genetic Feature Integration [PDF]
Opioids are an effective analgesic for acute and chronic pain, but also carry a considerable risk of addiction leading to millions of opioid use disorder (OUD) cases and tens of thousands of premature deaths in the United States yearly. Estimating OUD risk prior to prescription could improve the efficacy of treatment regimens, monitoring programs, and ...
arxiv
Reduction of breast cancer relapses with perioperative non-steroidal anti-inflammatory drugs: new findings and a review [PDF]
To explain a bimodal pattern of hazard of relapse among early stage breast cancer patients identified in multiple databases, we proposed that late relapses result from steady stochastic progressions from single dormant malignant cells to avascular micrometastases and then on to growing deposits.
arxiv
Functional neuroimaging of psychedelic experience: An overview of psychological and neural effects and their relevance to research on creativity, daydreaming, and dreaming [PDF]
Humans have employed an incredible variety of plant-derived substances over the millennia in order to alter consciousness and perception. Among the innumerable narcotics, analgesics, 'ordeal' drugs, and other psychoactive substances discovered and used in ritualistic contexts by cultures around the world, one class in particular stands out not only for
arxiv
A lipidated peptide derived from the C-terminal tail of the vasopressin 2 receptor shows promise as a new $β$-arrestin inhibitor [PDF]
$\beta$-arrestins play pivotal roles in seven transmembrane receptor (7TMR) signalling and trafficking. To study their functional role in the regulation of specific receptor systems, current research relies mainly on genetic tools, as few pharmacological options are available.
arxiv +1 more source