Results 11 to 20 of about 455,946 (356)

Design and Synthesis In Silico Drug-like Prediction and Pharmacological Evaluation of Cyclopolymethylenic Homologous of LASSBio-1514

Molecules, 2021
Acylhydrazones are still an important framework to the design of new bioactive compounds. As treatment of chronic pain represents a clinical challenge, we decided to modify the structure of LASSBio-1514 (1), previously described as anti-inflammatory and ...
Lidia Moreira Lima, Tiago Fernandes da Silva, Carlos Eduardo da Silva Monteiro, Cristiane Aparecida-Silva, Walfrido Bispo Júnior, Aline Cavalcanti de Queiroz, Magna Suzana Alexandre-Moreira, Gisele Zapata-Sudo, Eliezer J. Barreiro   +8 more
doaj   +1 more source

Pathophysiologic Approach to Pain Therapy for Complex Pain Entities: A Narrative Review

Pain and Therapy, 2020
Pain management is challenging for both clinicians and patients. In fact, pain patients are frequently undertreated or even completely untreated. Optimal treatment is based on targeting the underlying mechanisms of pain and tailoring the management ...
Martina Rekatsina, Antonella Paladini, Alba Piroli, Panagiotis Zis, Joseph V. Pergolizzi, Giustino Varrassi   +5 more
doaj   +1 more source

Evaluation of the Intracellular Signaling Activities of κ-Opioid Receptor Agonists, Nalfurafine Analogs; Focusing on the Selectivity of G-Protein- and β-Arrestin-Mediated Pathways

Molecules, 2022
Opioid receptors (ORs) are classified into three types (μ, δ, and κ), and opioid analgesics are mainly mediated by μOR activation; however, their use is sometimes restricted by unfavorable effects.
Masahiro Yamaguchi, Kanako Miyano, Shigeto Hirayama, Yusuke Karasawa, Kaori Ohshima, Eiko Uezono, Akane Komatsu, Miki Nonaka, Hideaki Fujii, Keisuke Yamaguchi, Masako Iseki, Masakazu Hayashida, Yasuhito Uezono   +12 more
doaj   +1 more source

Depressive symptoms are associated with analgesic use in people with Alzheimer's disease: Kuopio ALSOVA study. [PDF]

, 2015
Neuropsychiatric symptoms of Alzheimer's disease (AD) such as depression may be associated with pain, which according to the literature may be inadequately recognized and managed in this population.
ALSOVA Study Group, ., Bell, JS, Gilmartin, JF, Hallikainen, I, Koivisto, AM, Lönnroos, E, Martikainen, J, Salo, L, Törmälehto, S, Väätäinen, S   +9 more
core   +2 more sources

Analgesic and Anti-Arthritic Activities of Polysaccharides in Chaenomeles speciosa

Frontiers in Pharmacology, 2022
Chaenomeles speciosa (Sweet) Nakai has been long used as a folk medicine for rheumatic diseases treatment. This study aimed to investigate the effects and underlying mechanism of polysaccharides in Chaenomeles speciosa (CSP) on the pro-inflammatory ...
Doudou Huang, Doudou Huang, Shenggui Jiang, Zenan Du, Yanhong Chen, Dan Xue, Xiujuan Wang, Mengshuang Li, Feng Zhang, Wansheng Chen, Wansheng Chen, Lianna Sun   +11 more
doaj   +1 more source

Patterns of analgesic use, pain and self-efficacy: a cross-sectional study of patients attending a hospital rheumatology clinic [PDF]

, 2009
Background: Many people attending rheumatology clinics use analgesics and non-steroidal anti-inflammatories for persistent musculoskeletal pain. Guidelines for pain management recommend regular and pre-emptive use of analgesics to reduce the impact of ...
A Bandura, AL Harrison, D Berry, E Kalso, F Viller, F Wolfe, FJ Keefe, G Rose, H Brus, J Dowell, J Feinglass, J Fifield, JA Turner, JEM Sale, JR Kirwan, K Lorig, Kate Jolly, LI Aljasem, LR Harrold, M Brekke, M Gustafsson, M Hale, MA Rapoff, MJ Cross, N Barber, NC Beck, NT James, Paresh Jobanputra, R Neame, R Tuncay, RH Straub, Ruth Blamey, S McConnell, S Newman, S Wilcox, SE Ward, SH Saydah, Sheila Greenfield, SM Edworthy, TR Allison, W Katon, YH Lai   +41 more
core   +4 more sources

Oral application of magnesium‐L‐threonate enhances analgesia and reduces the dosage of opioids needed in advanced cancer patients—A randomized, double‐blind, placebo‐controlled trial

Cancer Medicine, 2023
Purpose To investigate the effects of oral administration of magnesium‐L‐threonate, a novel magnesium compound, on the analgesic effect of opioids in patients with advanced cancer.
Siyin Wu, Tian Jin, Bingjie Ma, Yun Ji, Xuehua Huang, Peiliang Wang, Xiaoming Liu, Boris V. Krylov, Xianguo Liu, Ke Ma   +9 more
doaj   +1 more source

Pharmacogenetics of analgesic drugs [PDF]

, 2013
• Individual variability in pain perception and differences in the efficacy of analgesic drugs are complex phenomena and are partly genetically predetermined.
Branford, R, Cregg, R, Gubbay, A, Russo, G, Sato, H   +4 more
core   +1 more source

Synthesis of silver and gold nanoparticles from leaf of Litchi chinensis and its biological activities

Asian Pacific Journal of Tropical Biomedicine, 2018
Objective: To synthesize and isolate silver and gold nanoparticles from Litchi chinensis leaf methanolic extract, and to evaluate its comparative biological activities including muscles relaxant, analgesic, anti-inflammatory and antidiarrheal.
Uzma Murad, Barkatullah, Shafqat Ali Khan, Muhammad Ibrar, Sami Ullah, Umbreen Khattak   +5 more
doaj   +1 more source

Cognitive impairment induced by delta9-tetrahydrocannabinol occurs through heteromers between cannabinoid CB1 and serotonin 5-HT2A receptors [PDF]

, 2015
Delta-9-tetrahydrocannabinol (THC), the main psychoactive compound of marijuana, induces numerous undesirable effects, including memory impairments, anxiety, and dependence.
A Busquets-Garcia, A Castañé, A Kern, A Manglik, A Pazos, A Pertovaara, A Zimmer, AC Magalhaes, AJ Venkatakrishnan, AL Bodor, Antoni Pastor, AR Best, Arnau Cordomí, BB Gorzalka, C Bombardi, C Castellano, C Ferrada, C Sanchis-Segura, Carmen Lluís, CP Vandermaelen, E Aso, E Fiorica-Howells, E Moreno, E Moreno, E Moreno, E Palazzo, E Puighermanal, E Puighermanal, E Valjent, Enric I. Canela, Eric J. Nestler, Estefanía Moreno, ET Weber, F Berrendero, F Rodríguez de Fonseca, F Simonin, F Steindel, FA Moreira, G Di Chiara, G Mengod, G Paxinos, G Porras, G Soria, Gemma Navarro, GM Thomas, HY Meltzer, J De Almeida, J González-Maeso, J González-Maeso, JC Parrish, JF Cheer, JF López-Giménez, JF López-Giménez, JJ Rodriguez, JM Franklin, JM Walker, JR Clapper, K Baba, K Mackie, K Monory, K Tsou, K Tsou, KA Gleason, L a. H Miner, L Callén, L Lanfumey, Laurence Lanfumey, Leonardo Pardo, Lesley A. Howell, LJ Sim-Selley, LP Martin, LTO Lee, M Bouvier, M Fribourg, M Lüttgen, M Schneider, M-M Mocanu, MJ Orejarena, N Kabli, NA Darmani, NB Eddy, NV Weisstaub, O Söderberg, P Pacher, P Rivera, Paola Gasperini, Patricia Robledo, Peter J. McCormick, R Franco, R Maldonado, R Mechoulam, R Mongeau, R Nygaard, R Schroder, Rafael de La Torre, Rafael Maldonado, RL Jakab, S Ferre, S Ferré, S Ferré, S González, S Haj-Dahmane, S Mato, S Pellow, SGF Rasmussen, SGF Rasmussen, SM Eggan, T Issad, T-W Chen, V Mendizábal, X Guitart, Xavier Viñals, Y-C Chiang   +112 more
core   +6 more sources