Results 231 to 240 of about 353,256 (314)

Intramyocardial Hematoma After Percutaneous Coronary Intervention for Chronic Total Occlusion: Two Case Reports

open access: yesCatheterization and Cardiovascular Interventions, EarlyView.
ABSTRACT Percutaneous coronary intervention (PCI) for chronic total occlusion (CTO) is an extremely challenging procedure, with intramyocardial hematoma (IMH) being one of its rare yet severe complications. In this report, we detail two cases of IMH occurring during PCI for CTO, emphasizing the importance of avoiding catheter pressure entrapment and ...
Xuefei Mu   +3 more
wiley   +1 more source

Managing Persistent Radial Artery Spasm During Coronary Catheterization: A Complex Case Study

open access: yesCatheterization and Cardiovascular Interventions, EarlyView.
ABSTRACT This case report details the management of persistent radial artery spasm during coronary catheterization, unresponsive to standard pharmacotherapy. After conventional methods failed, deep sedation, neuromuscular blockade, and orotracheal intubation proved essential.
Riccardo Mager   +3 more
wiley   +1 more source

Further Structure‐Activity Relationship of G Protein‐Gated Inwardly Rectifying Potassium Channels 1/2 Activators: Synthesis and Biological Characterization of In Vitro Tool Compounds

open access: yesChemMedChem, EarlyView.
Work presented here details the design and characterize novel G protein‐gated inwardly rectifying potassium channels (GIRK)1/2 activators. A new 4,4‐difluorocyclohexylpyrazole have been identified that confers improved potency and selectivity for GIRK1/2 versus GIRK1/4.
Sumaiya Nahid   +8 more
wiley   +1 more source

A Randomized Phase 1 Study Evaluating Pharmacokinetics, Safety, and Tolerability of a High‐Concentration, Long‐Acting Cabotegravir Formulation in Adults Without HIV

open access: yesClinical Pharmacology in Drug Development, EarlyView.
Abstract Long‐acting (LA) cabotegravir 200‐mg/mL (CAB200) injections are approved for HIV‐1 prevention and as a complete LA HIV‐1 treatment regimen with rilpivirine. A high‐concentration suspension formulation, cabotegravir 400 mg/mL (CAB400‐D), was developed to enable less frequent dosing and self‐administration. This phase 1, double‐blind, randomized
Kelong Han   +16 more
wiley   +1 more source

Diclofenac Detection via Inner‐Filter Effect using Pyridine‐Modified Triphenylene

open access: yesChemPlusChem, Accepted Article.
Triphenylene derivatives 3PY (2,3,6,7,10,11‐hexa(pyridine‐3‐yl)triphenylene) and 4PY (2,3,6,7,10,11‐hexa(pyridine‐4‐yl)triphenylene) were synthesized using a Suzuki–Miyaura coupling protocol and evaluated as potent chemosensors for the detection of diclofenac in solution phase.
Matti Haukka   +4 more
wiley   +1 more source

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