Results 31 to 40 of about 353,256 (314)

NSAIDs Naproxen, Ibuprofen, Salicylate, and Aspirin Inhibit TRPM7 Channels by Cytosolic Acidification

Frontiers in Physiology, 2021
Non-steroidal anti-inflammatory drugs (NSAIDs) are used for relieving pain and inflammation accompanying numerous disease states. The primary therapeutic mechanism of these widely used drugs is the inhibition of cyclooxygenase 1 and 2 (COX1, 2) enzymes ...
Rikki Chokshi, Orville Bennett, Tetyana Zhelay, J. Ashot Kozak   +3 more
doaj   +1 more source

Analgesic Mechanisms of Antidepressants for Neuropathic Pain

International Journal of Molecular Sciences, 2017
Tricyclic antidepressants and serotonin noradrenaline reuptake inhibitors are used to treat chronic pain, such as neuropathic pain. Why antidepressants are effective for treatment of neuropathic pain and the precise mechanisms underlying their effects ...
H. Obata
semanticscholar   +1 more source

Effect of Jyotishmati (Celastrus paniculatus) seeds in animal models of pain and inflammation

Journal of Ayurveda and Integrative Medicine, 2015
Background: Jyotishmati, scientifically known as Celastrus paniculatus Wild (Celastraceae) is one of the most important medicinal plants in Ayurveda.
Yogesh A Kulkarni, Sneha Agarwal, Mayuresh S Garud   +2 more
doaj   +1 more source

Contribution of Nrf2 Modulation to the Mechanism of Action of Analgesic and Anti-inflammatory Drugs in Pre-clinical and Clinical Stages

Frontiers in Pharmacology, 2019
Despite the progress that has occurred in recent years in the development of therapies to treat painful and inflammatory diseases, there is still a need for effective and potent analgesics and anti-inflammatory drugs.
L. Staurengo-Ferrari, Stephanie Badaro-Garcia, M. Hohmann, Marília F. Manchope, T. H. Zaninelli, R. Casagrande, W. Verri   +6 more
semanticscholar   +1 more source

Anti-nociceptive Effect of Entada Phaseoloides Seeds Formulation after Topical Application in Arthritic Wistar Rats [PDF]

Journal of Clinical and Diagnostic Research, 2013
Objectives: To study the effect of topical application of different formulations of Entada phaseoloides seeds for analgesic activity in arthritic wistar rats. Material and Methods: EP (Entada Phaseoloides) seeds were powdered after removing the shell.
Jayshree Shriram Dawane, Vijaya Anil Pandit, Bhagyashree D. Rajopadhye   +2 more
doaj   +1 more source

Lawsonia inermis possesses a significant analgesic activity compared to Waltheria indica, Moringa oleifera, Nigella sativa, and diclofenac in female Wistar rats [PDF]

The Iranian Journal of Veterinary Science and Technology, 2023
Pain is a severe symptom of many diseases, with an increasing percentage of people manifesting various types of pain. Medicinal plants provide analgesic potential with little toxicity.
Abdulfatai Aremu, Jiddah Idris, Ganiu Akorede, Aishat Olatumji, Afisu Basiru, Akeem Ahmed   +5 more
doaj   +1 more source

Loss of μ-opioid receptor signaling in nociceptors, and not spinal microglia, abrogates morphine tolerance without disrupting analgesic efficacy

Nature Network Boston, 2016
Opioid pain medications have detrimental side effects including analgesic tolerance and opioid-induced hyperalgesia (OIH). Tolerance and OIH counteract opioid analgesia and drive dose escalation.
G. Corder, V. Tawfik, Dong Wang, Elizabeth I Sypek, Sarah A. Low, Jasmine R Dickinson, Chaudy Sotoudeh, J David Clark, B. Barres, Christopher J. Bohlen, G. Scherrer   +10 more
semanticscholar   +1 more source

Pain Assessment of Elderly Patients with Cognitive Impairment in the Emergency Department: Implications for Pain Management—A Narrative Review of Current Practices

Pharmacy, 2017
Elderly people are susceptible to both falls and cognitive impairment making them a particularly vulnerable group of patients when it comes to pain assessment and management in the emergency department (ED). Pain assessment is often difficult in patients
Joshua Jones, Tin Fei Sim, Jeff Hughes
doaj   +1 more source

Pharmacological evaluation of processed Cannabis leaves as a non sedative analgesic: The novel approach

Journal of Ayurveda, 2021
Background: Ayurvedic pharmacopoeia records vivid indications of Cannabis (Bhanga) including its analgesic, sedative and intoxicant actions. For inhibition of intoxication, Ayurveda recommends certain processing (Shodhana) techniques for Cannabis.
Swagata Dilip Tavhare, Mukesh B Nariya, Rabinarayan Acharya   +2 more
doaj   +1 more source

Prevalence and incidence of prescription opioid analgesic use in Australia

British Journal of Clinical Pharmacology, 2018
The aims of the current study were to determine the prevalence and incidence of prescription opioid analgesic use in Australia and compare the characteristics of people with and without cancer initiating prescription opioid analgesics.
S. Lalic, J. Ilomäki, J. Bell, M. Korhonen, N. Gisev   +4 more
semanticscholar   +1 more source