Results 41 to 50 of about 622,793 (388)

Analgesic Mechanisms of Antidepressants for Neuropathic Pain

International Journal of Molecular Sciences, 2017
Tricyclic antidepressants and serotonin noradrenaline reuptake inhibitors are used to treat chronic pain, such as neuropathic pain. Why antidepressants are effective for treatment of neuropathic pain and the precise mechanisms underlying their effects ...
H. Obata
semanticscholar   +1 more source

Emergency Department Pain Management Following Implementation of a Geriatric Hip Fracture Program [PDF]

, 2017
Introduction: Over 300,000 patients in the United States sustain low-trauma fragility hip fractures annually. Multidisciplinary geriatric fracture programs (GFP) including early, multimodal pain management reduce morbidity and mortality. Our overall goal
Casey, Scott D, Hirsch, Calvin H, Mumma, Bryn E, Slee, Christina, Stevenson, Dane E, Tyler, Katren, Wolinsky, Philip R   +6 more
core   +4 more sources

Contribution of Nrf2 Modulation to the Mechanism of Action of Analgesic and Anti-inflammatory Drugs in Pre-clinical and Clinical Stages

Frontiers in Pharmacology, 2019
Despite the progress that has occurred in recent years in the development of therapies to treat painful and inflammatory diseases, there is still a need for effective and potent analgesics and anti-inflammatory drugs.
L. Staurengo-Ferrari, Stephanie Badaro-Garcia, M. Hohmann, Marília F. Manchope, T. H. Zaninelli, R. Casagrande, W. Verri   +6 more
semanticscholar   +1 more source

Combination of pharmacotherapy and lidocaine analgesic block of the peripheral trigeminal branches for trigeminal neuralgia: a pilot study [PDF]

, 2015
Classical trigeminal neuralgia (CTN) is treated predominantly by pharmacotherapy but side effects and unsuccessful occurs. The current study was carried out to evaluate the therapeutic effect of combination of pharmacotherapy and lidocaine block ...
Bruti, Gianluca, Delfini, Roberto, Di Lorenzo, Luigi, DI STANI, Fabrizio, Dugoni, Demo, Masala, Salvatore, Ojango, Christine, Piovesan, Elcio Juliato, Ruggeri, Andrea Gennaro, Simonetti, Giovanni   +9 more
core   +3 more sources

Analgesia induced by the epigenetic drug, L-acetylcarnitine, outlasts the end of treatment in mouse models of chronic inflammatory and neuropathic pain [PDF]

, 2017
Background: L-acetylcarnitine, a drug marketed for the treatment of chronic pain, causes analgesia by epigenetically up-regulating type-2 metabotropic glutamate (mGlu2) receptors in the spinal cord.
Battaglia, Giuseppe, Bernabucci, Matteo, Bruno, Valeria Maria Gloria, Cannella, Milena, Gradini, Roberto, Imbriglio, Tiziana, Mascio, Giada, Nicoletti, Ferdinando, Notartomaso, Serena, Scarselli, Pamela, Zappulla, Cristina   +10 more
core   +1 more source

Safety of opioid patch initiation in Australian residential aged care [PDF]

, 2015
Explores opioid use by aged care facility residents before and after initiation of transdermal opioid patches. Abstract Objective: To explore opioid use by aged care facility residents before and after initiation of transdermal opioid patches. Design:
Elizabeth Roughead, Lisa Pont, Svetla Gadzhanova   +2 more
core   +1 more source

Loss of μ-opioid receptor signaling in nociceptors, and not spinal microglia, abrogates morphine tolerance without disrupting analgesic efficacy

Nature Network Boston, 2016
Opioid pain medications have detrimental side effects including analgesic tolerance and opioid-induced hyperalgesia (OIH). Tolerance and OIH counteract opioid analgesia and drive dose escalation.
G. Corder, V. Tawfik, Dong Wang, Elizabeth I Sypek, Sarah A. Low, Jasmine R Dickinson, Chaudy Sotoudeh, J David Clark, B. Barres, Christopher J. Bohlen, G. Scherrer   +10 more
semanticscholar   +1 more source

Development and optimisation of novel oral formulation of an opioid analgesic using central composite design

Cogent Medicine, 2017
Introduction of matrix type sustained release systems were a breakthrough for novel oral drug delivery systems. Present research focuses on the development and evaluation of Fentanyl citrate sustained release formulations.
Meenal M. Rane, Amrita Bajaj
doaj   +1 more source

Analgesic and Sedative Effects of Different Doses of Dexmedetomidine Combined with Butorphanol in Continuous Analgesia after a Cesarean Section

Frontiers in Surgery, 2022
ObjectiveThe present study is designed to study the analgesic and sedative effect of different doses of dexmedetomidine combined with butorphanol in continuous analgesia after a cesarean section.MethodsA total of 60 puerperae undergoing a cesarean ...
Hui Liu, Yalin Wang, Fulong Li, Wei Ren, Li Yuan   +4 more
doaj   +1 more source

Prevalence and incidence of prescription opioid analgesic use in Australia

British Journal of Clinical Pharmacology, 2018
The aims of the current study were to determine the prevalence and incidence of prescription opioid analgesic use in Australia and compare the characteristics of people with and without cancer initiating prescription opioid analgesics.
S. Lalic, J. Ilomäki, J. Bell, M. Korhonen, N. Gisev   +4 more
semanticscholar   +1 more source