Results 211 to 220 of about 138,045 (265)
Some of the next articles are maybe not open access.
(-)-4-Hydroxymorphinanones: their synthesis and analgesic activity
Journal of Medicinal Chemistry, 1981A facile procedure is described for the conversion of morphine, via the diphosphate ester derivative 1 followed by catalytic reduction and treatment with Li/NH3, to 3-deoxy-7,8-dihydromorphine (3). Oxidation with benzophenone tert-butoxide converted 3 to the ketone 4, which on treatment with Zn/NH4Cl formed (-)-4-hydroxymorphinan-6-one 5. Reaction of 5
A, Manmade +3 more
openaire +2 more sources
Analgesic activity ofNepeta italica l.
Phytotherapy Research, 1999A screening study was performed on/by essential oils of Nepeta viscida Boiss and Nepeta italica L. using tail-flick and tail immersion (52.5 degrees C) methods. N. italica samples were collected from three different localities of Turkey. Surprisingly, only one of the essential oils showed significant activity, which was blocked by naloxone, indicating ...
Demir, T +3 more
openaire +4 more sources
[Anilides with analgesic and antipyretic activity].
Il Farmaco; edizione scientifica, 1985Several trimethylcyclopentyl and trimethylcyclopentenyl acetanilides, mono- and di-substituted on the aromatic nucleus as well as the corresponding acyl derivatives from aniline it self and corresponding phenylacetanilides, were prepared and tested as analgesics and antipyretics. Several compounds exhibit considerable activity in some cases superior to
Mule' A +5 more
openaire +2 more sources
Analgesic activity of Calotropis gigantea flower
Fitoterapia, 2007The alcoholic extract of the flowers of Calotropis gigantea was administered orally and explored for its analgesic activity in chemical and thermal models in mice. In acetic acid induced writhing test, an inhibition of 20.97% and 43.0% in the number of writhes was observed at the doses of 250 and 500 mg/kg, respectively. In the hot plate method the paw
A K, Pathak, A, Argal
openaire +2 more sources
Conformation-activity relationships of opiate analgesics
Journal of Computer-Aided Molecular Design, 1987Extensive conformational calculations were performed on the potent opiate analgesics etorphine, PET, R30490 and etonitazene to determine all of their many low-energy conformations. The results were used to characterize four possible models for binding of a simple pharmacophore, comprising two phenyl rings plus a protonated nitrogen, to opiate analgesic
Martin, J, Andrews, P
openaire +5 more sources
[Analgesic activity of pymadine].
Farmakologiia i toksikologiia, 1989The analgesic effect of 4-aminopyridine (pymadine) was studied in experiments on rats and mice at thermal and chemical pain stimulation. Pymadine (1, 3 and 5 mg/kg) exerted the analgesic effect when administered alone and concomitantly with analgin and morphine at chemical pain stimulation.
V, Mitsov, I, Bantutova
openaire +1 more source
Mutagenic and Analgesic Activities of Aniline Derivatives
Journal of Pharmaceutical Sciences, 1991Phenacetin (1), acetaminophen (2), acetanilide (3), 4-aminophenol (4), and aniline (5) were tested in S.J.L. Swiss mice for their mutagenic and analgesic activities. The S-analogues of 1 and 2, 4-mercaptoacetanilide (6) and 4-ethylthioacetanilide (7), respectively, were synthesized and tested in the same way to define if both activities could be ...
S M, Sicardi +2 more
openaire +2 more sources
Role of serotonin in the analgesic activity of calcitonin
European Journal of Pharmacology, 1984The acute effects of peripherally administered methysergide or phentolamine on the analgesic activity of salmon calcitonin (sCT) injected into the lateral ventricle were investigated in male rats. Methysergide, but not phentolamine, significantly (P less than 0.05) antagonized the analgesic activity of sCT at 60 and 120 min after the administration of ...
G, Clementi +3 more
openaire +2 more sources
Progress in drug research. Fortschritte der Arzneimittelforschung. Progres des recherches pharmaceutiques, 2016
Analgesics are agents which selectively relieve pain by acting in the CNS and peripheral pain mediators without changing consciousness. Analgesics may be narcotic or non-narcotic. The study of pain in animals raises ethical, philosophical, and technical problems. Both peripheral and central pain models are included to make the test more evident for the
openaire +1 more source
Analgesics are agents which selectively relieve pain by acting in the CNS and peripheral pain mediators without changing consciousness. Analgesics may be narcotic or non-narcotic. The study of pain in animals raises ethical, philosophical, and technical problems. Both peripheral and central pain models are included to make the test more evident for the
openaire +1 more source
2014
The differentiation between central and peripheral analgesic drugs is nowadays of more or less historical value. Most of the so-called peripheral analgesics possess anti-inflammatory properties and in some cases also antipyretic activity besides analgesia.
openaire +1 more source
The differentiation between central and peripheral analgesic drugs is nowadays of more or less historical value. Most of the so-called peripheral analgesics possess anti-inflammatory properties and in some cases also antipyretic activity besides analgesia.
openaire +1 more source