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Analgesic Activity of Endorphins
1983The demonstration that electrical stimulation of the mesencephalic gray in rats produced a profound analgesic response was one of the earliest reports providing experimental evidence suggestive of the presence of endogenous morphine-like substances in the brain (Reynolds, 1969).
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Analgesic Activity in Compounds Related to Amidone
Nature, 1947AMIDONE (dl-2-dimethylamino-4 : 4-diphenylheptan-5-one) or Hoechst 10820 was made and examined by the I.G. workers at Hoechst during the War. Short preliminary accounts of the properties of this compound have appeared in both the British and American literature, where the activities of some analogous compounds are also described1,2,3.
R H, THORP, E, WALTON, P, OFNER
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Syntheses, Antiinflammatory, and Analgesic Activities of Arylbiurets
Archiv der Pharmazie, 1990AbstractA number of arylbiurets were prepared and evaluated as antiinflammatory and analgesic agents by using the carrageenan paw edema and acetic acid stretching tests. Among them, the antiinflammatory activity of 1,3‐dimethyl‐5‐phenylbiuret (7), l‐ethyl‐3‐methyl‐5‐phenylbiuret (11), and 1,1,3‐trimethyl‐5‐phenylbiuret (13) were found to be more potent
M, Kajitani +8 more
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Evidence for analgesic activity of enkephalin in the mouse
Nature, 1976HUGHES et al.1 have recently described the identification and structure elucidation of methionine- and leucine-enkephalin, the postulated endogenous morphine-like factors from mammalian brain2–4. The structures were confirmed by comparing the mass spectra and electrophoretic mobilities of natural and synthetic material and their biological activities ...
H H, Buscher +6 more
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Analgesic Activity as Determined by the Nilsen Method
Journal of Pharmaceutical Sciences, 1972The Nilsen method for determining analgesic activity (pain stimulus and electrical pulsations to the mouse tail) was compared with the hot-plate procedure for several compounds including “pure” analgesics (agonists) (morphine, codeine, and meperidine), a known “pure” antagonist (naloxone), several so-called mixed agonist-antagonists (nalorphine ...
T D, Perrine +4 more
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2014
Many diseases have pain as a classical symptom requiring treatment with analgesics. Primary cancer and secondary metastases can lead to severe pain, which needs to be managed with strong analgesics, like opioid drugs. Opioids usually are safe when they are used correctly, but people who misuse opioids can become addicted.
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Many diseases have pain as a classical symptom requiring treatment with analgesics. Primary cancer and secondary metastases can lead to severe pain, which needs to be managed with strong analgesics, like opioid drugs. Opioids usually are safe when they are used correctly, but people who misuse opioids can become addicted.
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The analgesic activity of ceftriaxone
Ceftriaxone is an antibiotic from the cephalosporin group widely used to treat bacterial infections. Regardless of its antimicrobial activity, ceftriaxone has analgesic as well as anti-inflammatory and antioxidant properties. The mechanism of ceftriaxone’s analgesic effect is the ability to increase the expression and activity of the glutamate ...openaire +1 more source
Pharmacology and mechanisms of opioid analgesic activity
Acta Anaesthesiologica Scandinavica, 1997Opiates by an action at specific receptors can induce a highly selective alteration in the response of humans and animals to strong and otherwise aversive chemical, mechanical or thermal stimuli. Specific investigations in a variety of species from rodent to primate using microinjection techniques to examine the pharmacology of local drug action have ...
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Novel Type of Analgesic — Synthesis and Analgesic Activity
HETEROCYCLES, 1980Tetsuji Kametani +6 more
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American Cancer Society Nutrition and Physical Activity Guideline for Cancer Survivors
Ca-A Cancer Journal for Clinicians, 2022Colleen K Spees +2 more
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