Journal of Chemistry, 2020 This study was aimed to design novel diclofenac hydrazones having anti-inflammatory and analgesic activity with gastric sparing effect. A new series of 2-[2-(2,6-dichloroanilino)phenyl]-N’-[(substituted phenyl) methylidene] acetohydrazide derivatives (1 ...
Nawaf A. Alsaif +5 more
doaj +1 more source
Analgesia induced by the epigenetic drug, L-acetylcarnitine, outlasts the end of treatment in mouse models of chronic inflammatory and neuropathic pain [PDF]
, 2017 Background: L-acetylcarnitine, a drug marketed for the treatment of chronic pain, causes analgesia by epigenetically up-regulating type-2 metabotropic glutamate (mGlu2) receptors in the spinal cord.
Battaglia, Giuseppe +10 more
core +1 more source
Pain and analgesic use associated with skeletal-related events in patients with advanced cancer and bone metastases [PDF]
, 2005 PURPOSE: Bone metastases secondary to solid tumors increase the risk of skeletal-related events (SREs), including the occurrence of pathological fracture (PF), radiation to bone (RB), surgery to bone (SB), and spinal cord compression (SCC).
Roger von Moos +55 more
core +4 more sources
Pharmacokinetics and antinociceptive effects of tramadol and its metabolite O-desmethyltramadol following intravenous administration in sheep [PDF]
, 2015 Although sheep are widely used as an experimental model for various surgical procedures there is a paucity of data on the pharmacokinetics and efficacy of analgesic drugs in this species. The aims of this study were to investigate the pharmacokinetics of
A., Di Salvo +6 more
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Study of Analgesic activity of Bauhinia racemosa lam in Rats [PDF]
Veterinary World, 2009 The present study was carried out to evaluate the analgesic activity of the stem bark of the Bauhinia racemosa plant in rats.weighing around 150-200g. Aqueous & alcoholic extracts of dried stem bark of Bauhinia racemosa Lam.
V.I.Borikar +2 more
doaj
Generating Orally Active Galanin Analogues with Analgesic Activities [PDF]
ChemMedChem, 2012 AbstractThe endogenous neuropeptide galanin has anticonvulsant and analgesic properties mediated by galanin receptors expressed in the central and peripheral nervous systems. Our previous work showed that by combining truncation of the galanin peptide with N‐ and C‐terminal modifications afforded analogues that suppress seizures or pain upon ...
Charles R, Robertson +4 more
openaire +2 more sources
Transcranial magnetic stimulation as a new tool to control pain perception. [PDF]
, 2015 Treatment for chronic pain is frequently unsuccessful or characterized by side-effects. The high-frequency repetitive transcranial magnetic stimulation (HF-rTMS) has been suggested in the management of refractory chronic pain.
Frasca, Vittorio +3 more
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Annals of Abbasi Shaheed Hospital and Karachi Medical & Dental College, 2019 Objective: This study was conducted to investigate and compare the analgesic activity of methanolic ex- tracts of seeds of Cuminum Cyminum (L) and Centratherum anthelminticum (L)in mice.
Raana Mahmood +6 more
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Molecules, 2023 Crataegus turcicus is a plant endemic to Türkiye. For the first time, this study aimed to comparatively assess its flower-bearing branches, leaves, and fruits with other well-known Crataegus species (C. monogyna, C. pentagyna, and C. orientalis) in terms
Tansu Turnalar Ülger +7 more
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Pain outcomes in patients with bone metastases from advanced cancer: assessment and management with bone-targeting agents [PDF]
, 2014 Bone metastases in advanced cancer frequently cause painful complications that impair patient physical activity and negatively affect quality of life. Pain is often underreported and poorly managed in these patients.
A Kretzschmar +69 more
core +1 more source