Fused Triazole-Azepine Hybrids as Potential Non-Steroidal Antiinflammatory Agents
Scientia Pharmaceutica, 2023 Non-steroidal anti-inflammatory drugs (NSAIDs) are one of the oldest and most widely used groups of drugs nowadays. However, the problem of searching for and creating new NSAIDs remains open, primarily due to the risks owing to their short- and long-term
Sergii Demchenko +6 more
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Synthesis of 2-Methyl-3-indolylacetic Derivatives as Anti-Inflammatory Agents That Inhibit Preferentially Cyclooxygenase 1 without Gastric Damage [PDF]
, 2006 Novel substituted 2-methyl-3-indolylacetic derivatives were synthesized and evaluated for their activity in vitro and in vivo on COX-1 and COX-2. Active compounds were screened to determine their gastrointestinal tolerability in vivo in the rat.
C. Renner +9 more
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Aktualʹnì Pitannâ Farmacevtičnoï ì Medičnoï Nauki ta Praktiki, 2016 Background. The increase of NSAIDs safety is current direction of modern pharmacology, because of so-called "class-specific" adverse reactions, which are common to this class, and the leading place among them is occupied by gastro-intestinal toxicity. In
F. V. Hladkykh , N. H. Stepaniuk
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Molecules, 2023 B. crassifolia is a species that grows in various areas of Latin America. It was known to be useful for the treatment of different human ailments.
María de la Cabeza Fernández +4 more
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Benefits of thoracic epidural analgesia in patients undergoing an open posterior component separation for abdominal herniorrhaphy [PDF]
, 2017 INTRODUCTION: The implementation of open posterior component separation (PCS) surgery has led to improved outcomes for complex hernias. While the PCS technique has been shown to decrease recurrence rates, and provide a feasible option to repair hernias ...
Sellers, Austin
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Cerebral and cardiovascular effects of analgesic doses of ketamine during a target controlled general anesthesia: a prospective randomized study [PDF]
, 2017 Introduction: Ketamine is increasingly being used in various pain settings. The purpose of this study was to assess the effect of an analgesic dose of ketamine in the bispectral index (BIS), spectral edge frequency (SEF-95), density spectral array (DSA),
Araujo, A. M. +3 more
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Pharmacogenetics of analgesic drugs [PDF]
, 2013 • Individual variability in pain perception and differences in the efficacy of analgesic drugs are complex phenomena and are partly genetically predetermined.
Branford, R +4 more
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The analgesic effects of anti-inflammatory drugs from the point of view of different pharmacological test methods [PDF]
, 1964 1. The forms of irritation causing inflammation and pain are reviewed, with reference to the significance of histamine, serotonin and bradykinin and in particular to the interrelationship between inflammation and pain. 2.
Wilhelmi, G.
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National Journal of Physiology, Pharmacy and Pharmacology, 2019 Background: Medicinal plants have been the source of innumerable drugs. Opioids derived from plants are commonly used analgesics. However, they are associated with side effects ranging from vomiting, constipation to tolerance, and dependence.
Kunjumon Dayana, Megaravalli R Manasa
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An Overview of the Biological Activity of Pyrrolo[3,4-c]pyridine Derivatives
Pharmaceuticals, 2021 Pyrrolo[3,4-c]pyridine is one of the six structural isomers of the bicyclic ring system containing a pyrrole moiety fused to a pyridine nucleus. The broad spectrum of pharmacological properties of pyrrolo[3,4-c]pyridine derivatives is the main reason for
Anna Wójcicka, Aleksandra Redzicka
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