Results 61 to 70 of about 138,045 (265)

Abstract Representation of Movement Parameters in Basal Ganglia Output

Advanced Science, EarlyView.
The basal ganglia output provides a scalable velocity/position signal across behavioral contexts, supporting the idea that these variables are represented in the brain as abstract entities rather than as fixed changes in joint angles or specific sets of body effectors.
Ana Silvia Báez‐Cordero, Diana I. Ortega‐Romero, Claudia I. Pérez‐Díaz, Pavel E. Rueda‐Orozco   +3 more
wiley   +1 more source

Exploring the therapeutic potential of Eleusine indica plant: promising antioxidant and analgesic activity with lack of antimicrobial and thrombolytic activity

Journal of Applied Pharmaceutical Research
Background: Eleusine indica is used as a traditional medicine in Bangladesh. It is significantly valued for its wound-healing properties and is often used as an anthelmintic and pain reliever in rural areas.
Farhana Israt Jahan, Asif Hossain Anik, Sumaiya Akter   +2 more
doaj   +1 more source

An Injectable, Self‐Expanding Hemostatic Foam for Field‐Compatible Postpartum Hemorrhage Management

Advanced Science, EarlyView.
Postpartum hemorrhage is the leading cause of maternal death worldwide, yet many treatments are hard to use outside well‐equipped hospitals. This work introduces an easy‐to‐use device that rapidly delivers a degradable foam into the uterus. The foam stops bleeding through pressure and clotting support, offering a practical option for low‐resource ...
Charlotte Meyer, Noël Strasser, Ilakkiya Ravindrarajah, Elsa Wrenger, Kristian Ivkovic, Jan Ševčík, Sima Šarčević, Lenka Červenková, Jáchym Rosendorf, Václav Liška, Alexandre H. Anthis, Thomas Rduch, Inge K. Herrmann   +12 more
wiley   +1 more source

Decoding the Neural Circuit Underlying Context‐Cue Association in Retrieval of Morphine Reward Memory

Advanced Science, EarlyView.
Contextual cues recruit the glutamatergic vCA1–dmPFC pathway to retrieve morphine reward memory by reshaping cell‐type‐specific prefrontal microcircuit activity. Distinct regulation of PV+ and SST+ interneurons defines this hippocampal–prefrontal mechanism.
Zhifeng Shi, Guangying Li, Qian Yang, Rusun Liu, Linghan Gu, Mingmei Wang, John L. Waddington, Fuhai Ji, Xuechu Zhen   +8 more
wiley   +1 more source

ACUTE TOXICITY AND ANALGESIC ACTIVITY OF CRUDE FLAVONOIDS OF ACHILLEA WILHELMSII AND TEUCRIUM STOCKSIANUM

Khyber Medical University Journal, 2016
OBJECTIVES: To isolate total flavonoids from Achillea Wilhelmsii and Teucrium Stocksianum and screen them for possible analgesic activity and to determine the safe dose range of total flavonoids for preclinical studies in mice.
Niaz Ali, Ulfat Sultana, Syed Wadood Ali Shah, Muhammad Nabi, Shakir Ullah, Ismail Shah, Ghayour Ahmad   +6 more
doaj  

An Extracellular Pore‑Targeting Peptide Defines a Designable Allosteric Site in TRPV2

Advanced Science, EarlyView.
Structure‐guided peptide engineering yields Depiv2, a highly potent and subtype‐selective TRPV2 inhibitor that binds to the extracellular pore and remodels it into a closed, non‐conductive state. Depiv2 suppresses pathological cardiac hypertrophy, establishing the TRPV2 outer pore as a designable interface for selective peptide modulation.
Aiqin Zhu, Hongkun Wang, Jiawei Wang, Xiaolu Liu, Aerziguli Aierken, Lizhen Xu, Ping Liang, Fan Yang   +7 more
wiley   +1 more source

Sanguinarine–Chelerythrine from Coptis chinensis Offers Analgesic and Anti-Inflammatory Effects Without Gastrotoxicity

Pharmaceutics
Background: Pain is a major clinical and socioeconomic problem worldwide. The available therapies are not always effective and are often associated with the multiple adverse effects that reduce their clinical application.
Maciej Danielewski, Sylwia Zielińska, Anna Merwid-Ląd, Marta Szandruk-Bender, Wojciech Słupski, Maciej Włodarczyk, Tomasz Sozański, Piotr Ziółkowski, Adam Szeląg, Beata Nowak   +9 more
doaj   +1 more source

Analgesic effects of various extracts of the root of Abutilon indicum linn

Journal of Pharmacy and Bioallied Sciences, 2009
Purpose : Abutilon indicum (Linn.) sweet (Malvaceae) commonly called ′Country Mallow′ is a perennial plant up to 3 m in height. It is abundantly found as a weed in the sub-Himalayan tract and in the hotter parts of India.
Naveen Goyal, Sumitra Singh, Surendra K Sharma   +2 more
doaj   +1 more source

Aspirin‐Derived Salicyl‐CoA Drives Histone Lysine Salicylation Regulated by CBP and SIRT2

Advanced Science, EarlyView.
Aspirin‐derived salicyl‐CoA serves as a previously unrecognized acyl donor for protein lysine salicylation. This study identifies histone lysine salicylation as a reversible epigenetic modification regulated by CBP and SIRT2, expanding the biochemical actions of aspirin beyond its canonical acetylation‐dependent mechanisms and providing a new framework
Facai Zhang, Chuanzan Zhou, Jiaoyan He, Pengpeng Huang, Rong Zhang, Huan Hu, Meng Jiao, Linyi Hu, Feng Liu, Xiaolong Qi, Xiang He, Yunkai Yang, Y Eugene Chinn, Dechao Feng, Dahong Zhang, Qi Zhang   +15 more
wiley   +1 more source

Analgesic Effect of Ethanol Extract of Dillenia ochreata (Miq.) Teijsm. & Binn. Ex Martelli in Wistar Rats

Chempublish Journal
Dillenia ochreata is a traditional medicine used to treat wounds and scabies. In wound healing, one of the treatments is to reduce pain (analgesic). Some compounds of triterpenoid groups have been known to be active as analgesic compounds. The leaf of D.
Heni Yohandini, Fahdelaa Ghaniya, Muharni Muharni, Fitrya Fitrya   +3 more
doaj   +1 more source