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Opioid Analgesics and Opioid Antagonists
1980By opioid is meant any drug, regardless of chemical structure, that acts like morphine. The term opioid is preferred to the older term, opiate, for two reasons: first, because opiate implies presence in or derivation from opium, which indeed contains the analgesic drugs morphine and codeine but also contains thebaine, a strong stimulant (convulsive ...
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Anaesthesia & Intensive Care Medicine, 2019
Abstract The International Association for the Study of Pain defines pain as ‘an unpleasant sensory and emotional experience associated with actual or potential tissue damage or described in such terms of such damage’. This definition of the pain experience thus combines both the phenomenon of nociception (the sensory nervous system's response to ...
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Abstract The International Association for the Study of Pain defines pain as ‘an unpleasant sensory and emotional experience associated with actual or potential tissue damage or described in such terms of such damage’. This definition of the pain experience thus combines both the phenomenon of nociception (the sensory nervous system's response to ...
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Opioids and Other Analgesics [PDF]
, 2000 This chapter is concerned with those pain-killing drugs (analgesics) that are most likely to be misused, ranging from propoxyphene (Darvon) through the synthetic, opiatelike drugs to the major opiates, including morphine and heroin. The generalizations made here apply to almost all prescription painkillers with the exception of the newer prescription ...
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2006
Tramadol is a moderately potent analgesic [1, 2]. It is an aminocyclohexanol derivative or phenylpiperidine analogue of codeine and its analgesic effect is mediated through noradrenaline re-uptake inhibition, both increased release and decreased re-uptake of serotonin in the spinal cord and very weak μ-opioid receptor effect [1, 3–5].
Greta M Palmer, Brian J. Anderson
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Tramadol is a moderately potent analgesic [1, 2]. It is an aminocyclohexanol derivative or phenylpiperidine analogue of codeine and its analgesic effect is mediated through noradrenaline re-uptake inhibition, both increased release and decreased re-uptake of serotonin in the spinal cord and very weak μ-opioid receptor effect [1, 3–5].
Greta M Palmer, Brian J. Anderson
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Anaesthesia & Intensive Care Medicine, 2005
Abstract The non-steroidal anti-inflammatory drugs (NSAIDs) and paracetamol produce analgesia by inhibition of one of the three isoforms of cyclo-oxygenase (COX), which converts arachidonic acid to the cyclic endoperoxides from which the prostanoids are formed.
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Abstract The non-steroidal anti-inflammatory drugs (NSAIDs) and paracetamol produce analgesia by inhibition of one of the three isoforms of cyclo-oxygenase (COX), which converts arachidonic acid to the cyclic endoperoxides from which the prostanoids are formed.
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Pharmacological Mechanisms of Opioid Analgesics
Clinical Neuropharmacology, 1993The description of multiple classes of opioid receptors has had a major impact on our understanding of the mechanisms of analgesia. Three major classes of opioid receptors have been defined: mu, kappa, and delta. The mu receptors have been further subclassified into two distinct subtypes (mu 1 and mu 2), as have the delta receptors (delta 1 and delta 2)
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