Results 191 to 200 of about 84,046 (305)

Troriluzole attenuates opioid intake, reinforcing efficacy, seeking behaviours, physical dependence and antinociceptive tolerance in rats

British Journal of Pharmacology, EarlyView.
Background and Purpose Riluzole, approved for amyotrophic lateral sclerosis (ALS), has a glutamate‐modulating profile favourable for mitigating opioid addiction. It reduces neuronal glutamate release and enhances glutamate reuptake, offering advantages over agents that only increase glutamate reuptake.
Ewa Galaj, Saadet Inan, Guo‐Hua Bi, Sonita Wiah, George Adamson, Allen B. Reitz, Zheng‐Xiong Xi, Scott M. Rawls   +7 more
wiley   +1 more source

Concomitant Use of Analgesics and EGFR TKIs in Lung Cancer Patients: Outcomes and Perspectives From a Finnish Retrospective Register-Based Study. [PDF]

Cancer Med
Puuniemi LS, Iivanainen SME, Arffman M, Kaarteenaho RL, Koivunen JP.   +4 more
europepmc   +1 more source

Trends of Dispensed Opioids Prescribed by Australian Dentists: 2013–2022

Community Dentistry and Oral Epidemiology, EarlyView.
ABSTRACT Background In Australia, the prescribing of opioid medicines by dentists has increased in recent years, despite opioids not being first‐line treatment for dental pain. The aim of this longitudinal study was to examine the dispensing of opioids prescribed by dentists in Australia during 2013–2022.
Leanne Teoh, Marietta Taylor, Erin Kelty, Frank M. Sanfilippo, Mathew Lim, Michael McCullough, Christopher Etherton‐Beer, Alex Park, David Preen, Amy Page   +9 more
wiley   +1 more source

Effects of Drug Administration on Postoperative Pain in Orthognathic Surgery: A Systematic Review. [PDF]

Clin Exp Dent Res
Dipalma G, Inchingolo AM, Riccaldo L, Morolla R, Lauria P, Giorgio RV, Colonna V, Pennacchio BFP, Mancini A, Palermo A, Inchingolo AD, Inchingolo F.   +11 more
europepmc   +1 more source

A Scoping Review of the Emergence of Novel Synthetic Opioids in Australian Drug Markets: What Does This Mean for Harm Reduction Responses?

Drug and Alcohol Review, EarlyView.
ABSTRACT Issues Rising synthetic opioid deaths in North America, and the emergence of nitazene harms has driven concern about novel synthetic opioids (NSO) in Australia. This scoping review aimed to map what is known about NSOs in Australia. Approach Scoping review of peer‐reviewed and grey literature on NSO detections and harms.
Emmanuel Mammoliti, Suzanne Nielsen, Amanda Roxburgh   +2 more
wiley   +1 more source

Suzetrigine Approval Breaks a 25-Year Silence: A New Era in Non-Opioid Acute Pain Management. [PDF]

J Pain Res
Sibomana O, Okereke M, Hakayuwa CM.
europepmc   +1 more source

Emergence of Medetomidine in the Unregulated Drug Supply and Its Association With Hallucinogenic Effects

Drug and Alcohol Review, EarlyView.
ABSTRACT Introduction The unregulated drug supply in the United States is rapidly evolving, and veterinary tranquillisers have emerged as adulterants of concern, especially in illicitly‐manufactured fentanyl. Following the proliferation of xylazine, medetomidine, a more potent sedative, has recently appeared in multiple US states.
Adams L. Sibley, Madigan L. Bedard, Samuel Tobias, Brooke A. Chidgey, Irina G. Phillips, Alice Bell, Nabarun Dasgupta   +6 more
wiley   +1 more source

Prevalence and Predictors of Opioid Use Before Spine Surgery: A Multicenter, Cross-Sectional Observational Study. [PDF]

Pharmacol Res Perspect
Liu S, Stevens J, Tran C, Collins A, Duff J, Sutherland J, Oddie M, Naylor J, Patanwala A, Jauregui K, Penm J.   +10 more
europepmc   +1 more source

Good Practice in Postoperative and Procedural Pain Management 2nd Edition [PDF]

, 2012
CARTER, BERNIE, Curry, Joe, Howard, Richard, Jain, Anoo, Liossi, Christina, Morton, Neil, Rivett, Kate, Rose, Mary, Tyrell, Jennifer, Walker, Suellen, Williams, Glynn   +10 more
core  

Behavioural Effects and Naloxone Effectiveness With New Synthetic Opioids

Drug and Alcohol Review, EarlyView.
ABSTRACT Introduction The global drug market has seen an emergence of potent synthetic opioids, including benzimidazole‐derived substances known as nitazenes. These compounds have been implicated in fatal and non‐fatal overdoses. This review aims to synthesise current evidence on the pharmacological effects, potency and naloxone responsiveness of new ...
Suzanne Nielsen, João Pedro Silva, Jermaine D. Jones, Alex Krotulski, Dilkushi Poovendran, Deusdedit Muzangizi, Gilles Forte, Jason White, Sandra D. Comer   +8 more
wiley   +1 more source