Results 211 to 220 of about 62,305 (293)

Alkalinised lidocaine as an anaesthetic before onabotulinumtoxinA injections. a randomised trial

BJU International, Volume 135, Issue 4, Page 638-647, April 2025.
Objectives To evaluate the effect of intravesical alkalinised lidocaine as an anaesthetic treatment on procedural pain during intradetrusor onabotulinumtoxinA (BTX‐A) injections for overactive bladder. Patients and Methods This single‐centre, randomised, double‐blind, placebo‐controlled two period crossover trial was conducted on women scheduled for ...
Meryam El Issaoui, Marlene Elmelund, Niels Klarskov   +2 more
wiley   +1 more source

Comparative analysis of pain management protocols in pediatric and adult emergency medicine: a narrative review. [PDF]

Front Public Health
Abdullah I, Khan S, Hashim S, Shakeel F, Amro M, Sheikh Saleh D, Hassan FE.   +6 more
europepmc   +1 more source

[Opioid analgesics].

Vojnosanitetski pregled, 2004
Sonja, Vucković, Milica, Prostran, Milovan, Ivanović, Zoran, Todorović, Radan, Stojanović, Zorica, Nesić, Ivana, Matić, Slobodan, Milovanović   +7 more
openaire   +1 more source

Activation of peripheral NOP receptors reduces periorbital mechanical allodynia evoked by CGRP in mice

British Journal of Pharmacology, EarlyView.
Background and Purpose Migraine is a neurovascular disorder largely mediated by calcitonin gene‐related peptide (CGRP). This study explores the role of the nociceptin/orphanin FQ (N/OFQ)–N/OFQ receptor (NOP) system in CGRP‐induced periorbital mechanical allodynia (PMA) in mice.
Chiara Sturaro, Pietro Pola, Michela Argentieri, Alessia Frezza, Matilde Marini, Francesco De Logu, Valentina Albanese, Marie Soukupova, Davide Malfacini, Nurulain T. Zaveri, Romina Nassini, Dane D. Jensen, Pierangelo Geppetti, Girolamo Calò, Chiara Ruzza   +14 more
wiley   +1 more source

SAGE (safer analgesia): a protocol for a pragmatic cluster randomised controlled trial to reduce the use of high-risk medicines in people with chronic back and/or neck pain. [PDF]

BMJ Open
Abdel Shaheed C, McLachlan AJ, Mathieson S, Ivers R, Clare PJ, Blyth F, Stanaway F, Degenhardt L, Gnjidic D, French S, Thompson R, Hilmer S, Pinheiro M, Machado GC, Austin T, Gardner T, Sharma S, Bennett A, Boogs M, McMaugh J, Vizza L, Downie A, Tracy M, Hopkins R, Osman R, Lindley RI, Hayes C, McCaffery K, Maher C.   +28 more
europepmc   +1 more source

Novel approaches for drug development against chronic primary pain: A systematic review

British Journal of Pharmacology, EarlyView.
Abstract Chronic primary pain (CPP) persisting for more than 3 months, associated with significant emotional distress without any known underlying cause, is an unmet medical need. Traditional or adjuvant analgesics do not provide satisfactory pain relief for a great proportion of these patients.
Valéria Tékus, Éva Borbély, Andreas Goebel, Ralf Baron, Zsófia Hajna, Zsuzsanna Helyes   +5 more
wiley   +1 more source

Effect of adding dexmedetomidine to fascia iliaca compartment block on postoperative analgesia in patients undergoing femoral fractures surgery: A randomized double-blind clinical trial. [PDF]

J Int Med Res
Karami N, Karami T, Taleb H, Ghodratizadeh M.   +3 more
europepmc   +1 more source

Optimal intrathecal morphine dosing for revision hip arthroplasty: an observational study

Anaesthesia, EarlyView.
Shalini Patel, Vassia Paschou, Jane Quinlan, Ben Kendrick, Nicolas Suarez   +4 more
wiley   +1 more source

Cannabigerol reverses mechanical allodynia through α2A‐adrenergic modulation of thalamocortical signaling in chemotherapy‐induced neuropathy

British Journal of Pharmacology, EarlyView.
Abstract Background and Purpose Chemotherapy‐induced peripheral neuropathy (CIPN) is a prevalent and treatment‐resistant side effect of platinum‐based chemotherapy, characterised by mechanical allodynia. Cannabigerol (CBG), a non‐psychoactive cannabinoid, has shown antinociceptive potential, but its site and mechanism of action remain unclear.
Quinn W. Wade, Nathan Morris, Diana E. Sepulveda, Alonso Cortez‐Resendiz, Christopher Brandl, Jennifer E. Lausch, Mariya Starostina, Nicholas M. Graziane   +7 more
wiley   +1 more source