Results 221 to 230 of about 62,166 (293)

Identification, reliability, and validity of drug–drug interaction checkers in chronic diseases: A systematic review

British Journal of Pharmacology, EarlyView.
Abstract Drug–drug interactions (DDIs) pose major risks in chronic disease management where polypharmacy is common. Although digital DDI tools are used widely to aid healthcare professionals, tools rely on theoretical interactions. This limitation questions their reliability and validity for clinical relevancy.
Brayden Ng Gibson, Sri Chodapuneedi, Huan Yee Koh, Sugandha Gupta, Danijela Gasevic, Anna Yuanyuan Wang, Catia Marzolini, Saye Khoo, Lorena Romero, Lachlan Dalli, Jack Janetzki, Harvey Jia Wei Koh, Stella Talic   +12 more
wiley   +1 more source

Pregabalin as a co-analgesic in patients undergoing laparoscopic sleeve gastrectomy: a double-blind, randomized, prospective clinical trial. [PDF]

Sci Rep
Mieszczański P, Jurczak M, Janiak M, Górniewski G, Ziemiański P, Cylke R, Skrzypek P, Godlewska I, Trzebicki J.   +8 more
europepmc   +1 more source

Underpowered study design invalidates conclusions of LTAP versus LWI in peritoneal endometriosis surgery

Acta Obstetricia et Gynecologica Scandinavica, EarlyView.
Ding Li, Song Ye
wiley   +1 more source

In silico prediction of novel effective combinational treatment of chronic pain in individual patients: A joint white paper of the H2020 QSPainRelief consortium

British Journal of Pharmacology, EarlyView.
Abstract Opioids are prescribed widely for chronic pain despite well‐recognised risks and variable long‐term benefit, reflecting the lack of effective alternatives for many patients. Combination therapies offer a promising strategy to enhance efficacy whilst reducing side effects.
André Mouraux, Solenn Gousset, Beltrán Alvarez, Monica Baiula, Wouter Bakker, Andrea Bedini, Monir Bertayli, Divakar Budda, Robert Carr, Elisabetta Cuna, Óscar Díaz, Nina Donner, Jesús Giraldo, Geert‐Jan Groeneveld, Berfin Gülave, David Guydan, Hemme Hijma, Rafael Maldonado, Pedro Renault, Carlos Rinaudo, Jeroen Elaissaiss‐Schaap, Athan Spiros, Sara Stoeber, Petri Takkala, Daan van Valkengoed, Coen van Hasselt, Elizabeth (Liesbeth) CM de Lange   +26 more
wiley   +1 more source

Inhibition of kynurenine 3‐monooxygenase (KMO) reduces fentanyl and sucrose intake and relapse‐like behaviour in rats

British Journal of Pharmacology, EarlyView.
Abstract Background and Purpose Opioid use disorder, particularly involving fentanyl, poses major challenges due to high relapse rates and limited effectiveness of pharmacotherapies. The kynurenine pathway has emerged as a target for addiction treatment through its modulation of glutamatergic and dopaminergic neurotransmission.
Carlos Núñez‐de la Calle, Lluna Careaga, Stefanie Malan‐Müller, Álvaro del Río‐García, Yaiza Trueba, Leticia Gil de Biedma‐Elduayen, Nuria Morales‐Puerto, Rebeca Vidal, Åsa Wiman, Sophie Erhardt, María Dolores Gutiérrez‐López, Esther O'Shea, María Isabel Colado   +12 more
wiley   +1 more source

Opioid consumption, availability, and policy alignment in primary hospice and palliative care in China: a multicomponent comparative analysis. [PDF]

Support Care Cancer
Fan Y, Ye Z, Jiang M, Jing L, Zhang H, Tang Z, Qiao H, Wang X, Zhang X, Tang Y, Liu L.   +10 more
europepmc   +1 more source

Tapentadol-induced urticarial rash in a patient with acute pancreatitis.

Indian J Pharmacol
Deshidi S, Hanumanthu V, Mahajan G, Appasani S.   +3 more
europepmc   +1 more source

Opioid-based versus opioid-sparing patient-controlled analgesia using ketorolac and nefopam after total knee arthroplasty: a randomized, double-blind, non-inferiority trial. [PDF]

Korean J Anesthesiol
Han J, Jung H, Kim MK, Park YB, Min S.
europepmc   +1 more source

Postoperative Care and Management in Pediatric Hematology‐Oncology Patients

European Journal of Haematology, EarlyView.
ABSTRACT Pediatric patients with hematologic and oncologic diseases often undergo surgical procedures as part of diagnosis and therapy. These include central venous catheter placements, tumor resections, lymph node and bone marrow biopsies, among others.
Shachi Srivatsa, Sara A. Mansfield
wiley   +1 more source

Comparative analysis of analgesic mechanisms in craniotomy pediatric patients: a scoping review. [PDF]

Childs Nerv Syst
Jenkins A, Witten G, Azam F, Guirguis M, Shukla I, Patel S, Guirguis F, Farid M, O'Leary S, Barrie U, Aoun SG, Braga BP.   +11 more
europepmc   +1 more source