Cohort Study of the Impact of High-Dose Opioid Analgesics on Overdose Mortality [PDF]
, 2016 OBJECTIVE: Previous studies examining opioid dose and overdose risk provide limited granularity by milligram strength and instead rely on thresholds. We quantify dose-dependent overdose mortality over a large spectrum of clinically common doses.
Dasgupta, Nabarun +5 more
core +2 more sources
In vitro and in vivo pharmacological activities of 14-o-phenylpropyloxymorphone, a potent mixed mu/delta/kappa-opioid receptor agonist with reduced constipation in mice [PDF]
, 2018 Pain, particularly chronic pain, is still an unsolved medical condition. Central goals in pain control are to provide analgesia of adequate efficacy and to reduce complications associated with the currently available drugs.
Lattanzi, Roberta +4 more
core +2 more sources
IUPHAR Review - Bivalent and bifunctional opioid receptor ligands as novel analgesics
Pharmacological Research, 2023 Though efficacious in managing chronic, severe pain, opioid analgesics are accompanied by significant adverse effects including constipation, tolerance, dependence, and respiratory depression.
Kyle J. Rehrauer +1 more
doaj
Prescribing and administration of opioid analgesics in residents of aged care facilities
Journal of Research in Pharmacy Practice, 2019 Objective: Optimal pain management in residents requires an understanding of prescribing and administration of opioid analgesics. This study aimed to describe opioid administration for elderly residents in a selection of aged care facilities.
Areej Numan Hussein, Lynne Emmerton
doaj +1 more source
Individualized Risk Assessment of Preoperative Opioid Use by Interpretable Neural Network Regression [PDF]
arXiv, 2022 Preoperative opioid use has been reported to be associated with higher preoperative opioid demand, worse postoperative outcomes, and increased postoperative healthcare utilization and expenditures. Understanding the risk of preoperative opioid use helps establish patient-centered pain management.
arxiv
Joint Distribution and Transitions of Pain and Activity in Critically Ill Patients [PDF]
, 2020 Pain and physical function are both essential indices of recovery in critically ill patients in the Intensive Care Units (ICU). Simultaneous monitoring of pain intensity and patient activity can be important for determining which analgesic interventions can optimize mobility and function, while minimizing opioid harm. Nonetheless, so far, our knowledge
arxiv +1 more source
Investigating Dissemination of Scientific Information on Twitter: A Study of Topic Networks in Opioid Publications [PDF]
arXiv, 2021 One way to assess a certain aspect of the value of scientific research is to measure the attention it receives on social media. While previous research has mostly focused on the "number of mentions" of scientific research on social media, the current study applies "topic networks" to measure public attention to scientific research on Twitter.
arxiv
Is this opioid analgesic tolerance?
Journal of Pain and Symptom Management, 1995 Tolerance to the analgesic effect of opioids is a poorly understood phenomenon. While generally accepted to be an uncommon problem, it clearly can present major management difficulties in some patients. This case report illustrates different aspects of tolerance, describes a management approach using different opioids, and provides a focus for ...
Robin L. Fainsinger, Eduardo Bruera
openaire +3 more sources
PLoS ONE, 2021 BackgroundShortages of opioid analgesics are increasingly common, interfere with patient care and increase healthcare cost. This study characterized the incidence of shortages of opioid analgesics in the period 2015-2019 and evaluated potential ...
Rosa Rodriguez-Monguio +2 more
doaj +1 more source
Trends and characteristics of accidental and intentional codeine overdose deaths in Australia [PDF]
, 2015 Examines trends in codeine-related mortality rates in Australia, and the clinical and toxicological characteristics of codeine-related deaths. Abstract Objectives: To examine trends in codeine-related mortality rates in Australia, and the clinical and ...
Amanda Roxburgh +6 more
core +1 more source