Results 31 to 40 of about 48,024 (241)
Advanced Science, EarlyView.This work introduces wireless‐powered fully implantable spinal cord stimulation (SCS) in freely moving animal models, supporting diverse ethological paradigms. kHz stimulation with real‐time digital programming offers versatile, dynamically optimized therapy. Scalable fabrication ensures high N studies and seamless translation.
Allie J. Widman +11 more
wiley +1 more source
Opioid Analgesics in the Management of Neuropathic Pain
Pain Research and Management, 2000 The role of antidepressants and anticonvulsants in the management of neuropathic pain has been well established. However, up to 50% of patients obtain inadequate pain relief with the use of either or both of these agents; in this subpopulation, an opioid
Dwight Moulin
doaj +1 more source
Медицина болю, 2020 The current strategy of rational perioperative analgesia involves reducing the use of opioid analgesics and preventing associated side effects. Today it is known that the use of opioid analgesics can further lead to the development of hyperalgesia ...
Dmytro Dmytriiev +4 more
doaj +1 more source
Peripheralization Strategies Applied to Morphinans and Implications for Improved Treatment of Pain
Molecules, 2023 Opioids are considered the most effective analgesics for the treatment of moderate to severe acute and chronic pain. However, the inadequate benefit/risk ratio of currently available opioids, together with the current ‘opioid crisis’, warrant ...
Helmut Schmidhammer +3 more
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Advanced Science, EarlyView.Intratracheal neomycin alters pulmonary microbiota, activating the vagus nerve via lung brain‐derived neurotrophic factor/tropomyosin receptor kinase B (BDNF/TrkB) pathway, further projecting to nucleus of solitary tract (NTS), then dorsal raphe nucleus (DRN), where activated serotoninergic neurons increase brain serotonin, alleviating migraine.
Biying Liu +7 more
wiley +1 more source
AASLD practice guidance on drug, herbal, and dietary supplement–induced liver injury
, 2022 Hepatology, EarlyView.
Robert J. Fontana +6 more
wiley +1 more source
Acute Pain, 2008 Although there is no “ideal analgesic,” scientists and clinicians alike continue to search for compounds with qualities which may approach the “ideal analgesic.” Characteristics of an “ideal” analgesic may include: the agent is a full agonist providing optimal/maximal analgesia for a wide range/variety of pain states (e.g., broad spectrum analgesic ...
openaire +4 more sources
Advanced Science, EarlyView.S‐ketamine binds directly to SIRT2, facilitating its interaction with NF‐κB p65. This interaction reduces the acetylation of NF‐κB p65 and inhibits its activation, thereby exerting anti‐inflammatory and antidepressant effects. Created by BioRender.
Cong Lin +7 more
wiley +1 more source
Advanced Science, EarlyView.How locus coeruleus noradrenergic‐spinal projections and subsequent α2A adrenoceptors‐CaMKII signaling cascades contribute to electroacupuncture‐induced antinociception in postoperative pain in mice is described. Abstract Postoperative pain remains a significant challenge in healthcare.
Wen‐Guang Chu +13 more
wiley +1 more source
Changes in analgesic strategies for lobectomy from 2009 to 2018Central MessagePerspective
JTCVS Open, 2021 Objective: To evaluate trends in the use of epidural analgesia and nonopioid and opioid analgesics for patients undergoing lobectomy from 2009 to 2018.
Theresa Lo, MD +9 more
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