Results 61 to 70 of about 80,053 (258)

Impact of diclofenac risk minimization measures addressing cardiovascular risk on analgesic use in musculoskeletal disorders

British Journal of Clinical Pharmacology, EarlyView.
Aims In 2013, risk minimization measures (RMMs) were introduced in Europe to address the increased cardiovascular risk linked to diclofenac. This study aimed to assess the impact of those RMMs on analgesic use. Methods Primary care data from CPRD GOLD (UK) were used.
Tomas Lasys, Yared Santa‐Ana‐Tellez, Satu J. Siiskonen, Daniala L. Weir, Rolf H. H. Groenwold, Helga Gardarsdottir   +5 more
wiley   +1 more source

Trends in analgesia prescribing in primary care in Ireland and England between 2014 and 2022: A repeated cross‐sectional study

British Journal of Clinical Pharmacology, EarlyView.
Aims Analgesic medicines are an important component of pain management, with different medicines carrying different risks and benefits. The aim of this study was to examine trends in analgesic prescribing in Ireland and England between 2014 and 2022. Methods Monthly data on medicines prescribed and dispensed in primary care were used. For Ireland, data
Molly Mattsson, Michelle Flood, Brian MacKenna, Emma Wallace, Fiona Boland, Ciara Kirke, Mary E. Walsh, Tom Fahey, Frank Moriarty   +8 more
wiley   +1 more source

ATHENA: A Phase 3, Open-Label Study Of The Safety And Effectiveness Of Oliceridine (TRV130), A G-Protein Selective Agonist At The µ-Opioid Receptor, In Patients With Moderate To Severe Acute Pain Requiring Parenteral Opioid Therapy. [PDF]

, 2019
Background:Pain management with conventional opioids can be challenging due to dose-limiting adverse events (AEs), some of which may be related to the simultaneous activation of β-arrestin (a signaling pathway associated with opioid-related AEs) and G ...
Beard, Timothy L, Bergese, Sergio D, Berkowitz, Richard D, Brzezinski, Marek, Cochrane, Kristina, Habib, Ashraf S, Hammer, Gregory B, Mace, Sharon E, Minkowitz, Harold S, Pan, Peter H, Wase, Linda   +10 more
core  

Trends in opioid prescribing in Scandinavian countries from 2010 to 2023: Insights from multi‐metric evaluation

British Journal of Clinical Pharmacology, EarlyView.
Aims Monitoring opioid prescribing across different healthcare systems is essential to understanding population‐level exposure and informing global health policies. This study examined opioid utilization in Scandinavian countries between 2010 and 2023 using multiple complementary metrics, addressing the limitations of single‐metric comparisons ...
Gabriela Rolová, Svetlana Skurtveit, Marte Handal, Geana Paula Kurita, Torgeir Gilje Lid, Ingvild Odsbu, Mikael Hoffmann   +6 more
wiley   +1 more source

Neuroleukemiosis Masquerading as Drug Toxicity in an Adolescent With Refractory AML

American Journal of Hematology, EarlyView.
Nia Choi, Deborah Schady, Tim Lotze, Jill Ann Jarrell, Alexandra Rodriguez‐Hernandez, Sandra Aziz, Karen K. Moeller, Joanna S. Yi, Suzanne Woodbury, Andrea N. Marcogliese, Zoann E. Dreyer, Eric S. Schafer   +11 more
wiley   +1 more source

Combination vs. single‐drug nonprescription analgesics for acute pain management: A narrative review

British Journal of Clinical Pharmacology, EarlyView.
Combining nonprescription analgesics with different mechanisms of action has been proposed as a rational strategy to optimize the management of acute pain. This review assessed the efficacy and safety of nonprescription analgesics, including paracetamol (acetaminophen), metamizole and nonsteroidal anti‐inflammatory drugs (NSAIDs) used in combination vs.
Ali Mobasheri, Bart Morlion, Vidhu Sood Sethi, Mary Cardosa, Oscar Della Pasqua, Pranab Kalita   +5 more
wiley   +1 more source

Managing Prolonged Pain After Surgery: Examining the Role of Opioids. [PDF]

, 2018
A notable minority of patients experience persistent postsurgical pain and some of these patients consequently have prolonged exposure to opioids. Risk factors for prolonged opioid use after surgery include preoperative opioid use, anxiety, substance ...
Pozek, John-Paul J., Schwenk, Eric S., Viscusi, Eugene R.   +2 more
core   +1 more source

Classification of pain and its treatment at an intensive care rehabilitation clinic [PDF]

, 2016
Introduction Treatment in an Intensive Care Unit (ICU) often necessitates uncomfortable and painful procedures for patients throughout their admission.
Daniel, M., Devine, H., Kinsella, J., MacTavish, P., McPeake, J., Quasim, T.   +5 more
core   +1 more source

Quality indicators for safe and effective use of medications in long‐term care settings: A systematic review

British Journal of Clinical Pharmacology, EarlyView.
People accessing aged care services are increasingly older and often experience multimorbidity and polypharmacy, which puts them at risk of medication‐related harm. Quality indicators (QIs) can assist with monitoring, benchmarking and informing initiatives to reduce medication‐related harm.
Daria S. Gutteridge, Annabel H. Calder, Jacquelina Stasinopoulos, Sara Javanparast, Gillian E. Caughey, Jodie B. Hillen, Andrew C. Stafford, Gregory M. Peterson, Maria C. Inacio, Jyoti Khadka, Lisa M. Kalisch Ellett, Shane L. Jackson, Peter D. Hibbert, Monica L. Cations, Megan E. Corlis, Solomon C. Yu, Malcom J. Clark, Natalie R. Soulsby, Elizabeth Manias, Grace H.‐Y. Yoo, Janet K. Sluggett   +20 more
wiley   +1 more source

Designing an automated clinical decision support system to match clinical practice guidelines for opioid therapy for chronic pain [PDF]

, 2010
Background Opioid prescribing for chronic pain is common and controversial, but recommended clinical practices are followed inconsistently in many clinical settings.
AP Farmer, AX Garg, BM Kuehn, Brigit Vucic, Charles D Sintek, Dan Wang, David J Clark, Denise Daniels, DF Sittig, DL Hunt, DW Bates, G Worrall, J Gennari, Jack Rosenberg, Jan Elliott, JC Ballantyne, Jodie A Trafton, K Kawamoto, K Redmond, L Manchikanti, LM Frantsve, LM Yanni, M Glajchen, M Goldstein, Martha C Michel, Mary K Goldstein, MC Michel, Michael E Clark, MJ Pletcher, MK Goldstein, MK Goldstein, MK Goldstein, RA Miller, RN Shiffman, S Martins, Samson W Tu, SM Maviglia, SR Savage, Steve Balt, Susana B Martins, SW Tu, SW Tu, VA/DoD Opioid Therapy for Chronic Pain Working Group, W Dick, WM Tierney   +44 more
core   +3 more sources