Results 151 to 160 of about 46,932 (244)

Opioids in breast cancer: Between analgesia and modulation of tumour progression

British Journal of Pharmacology, EarlyView.
Preclinical investigations consistently demonstrate that activation of μ‐opioid receptors and δ‐opioid receptors promote proliferation, migration, angiogenesis, epithelial‐mesenchymal transition, acquisition of cancer stem cell phenotypes, and chemoresistance.
Marianna Ciwun, Anna Tankiewicz‐Kwedlo, Dariusz Pawlak   +2 more
wiley   +1 more source

Implementation of a standardized pain management protocol reduces the variability in prescription patterns following pediatric supracondylar humerus fractures. [PDF]

Bull Hosp Jt Dis (2013)
Jeong Y, Birnbaum A, Cooper J, Castañeda P, Karamitopoulos M.   +4 more
europepmc   +1 more source

Comprehensive transduceromic profiling of NOP receptor ligands at different Gα subunits

British Journal of Pharmacology, EarlyView.
Abstract Background and Purpose The nociceptin/orphanin FQ (N/OFQ) peptide receptor (NOP) is an opioid receptor family member with distinct pharmacology and broad therapeutic potential. NOP receptors regulate functions such as nociception, stress reactivity, reward, mood, autonomic tone, immunity and sleep/wake cycle.
Davide Malfacini, Riccardo Camilotto, Michele Maritan, Erika Morrone, Stephen Afriyie Boateng, Anna Vacilotto, Salvatore Pacifico, Remo Guerrini, Nurulain T. Zaveri, Girolamo Calo'   +9 more
wiley   +1 more source

Racial and Ethnic Disparities in Pharmacologic and Non-Pharmacologic Pain Management Among Older Cancer Survivors. [PDF]

Cancer Med
Bhattacharyya O, Elsaid MI, Punches BE, Ni A, Felix AS, Donneyong MM.   +5 more
europepmc   +1 more source

Novel drugs approved by the EMA, the FDA and the MHRA in 2025: A year in review

British Journal of Pharmacology, EarlyView.
Abstract In the 2025 novel drug mini‐review, one can take a full measure of the ingenuity that underlies current drug design and development, despite the year's smaller harvest (46 novel drugs) compared to 2024 (53) and 2023 (70). 54% of the novel drugs are first‐in‐class (FIC).
Andreas Papapetropoulos, Stavros Topouzis, Steve P. H. Alexander, Miriam M. Cortese‐Krott, Zsuzsanna Helyes, Kirill Martemyanov, Claudio Mauro, Nithyanandan Nagercoil, Reynold A. Panettieri Jr, Hemal H. Patel, Rainer Schulz, Barbara Stefanska, Gary J. Stephens, Nathalie Vergnolle, Xin Wang, Stephen Ward, Péter Ferdinandy   +16 more
wiley   +1 more source

Platelet‐Rich Fibrin Can Improve Septoplasty Results: A Prospective Randomised Controlled Trial

Clinical Otolaryngology, EarlyView.
ABSTRACT Aim This study aims to assess the impact of platelet‐rich fibrin (PRF) on nasal mucociliary clearance (NMC) time and post‐operative pain following septoplasty. Patients and Methods This trial was conducted involving patients who underwent septoplasty. Participants were randomly assigned to either a control group or a PRF group.
Emre Solguntekin, Sedat Çağlı, Kerem Kökoğlu, Emrah Gülmez   +3 more
wiley   +1 more source

Profile of analgesic prescription by medical specialties: A comparative study of symptomatic management in emergency care between orthopedics and other specialties-A retrospective observational brief report. [PDF]

PLoS One
Penna LF, Wu AA, Madureira R, Fonseca RLA, Zelada RK, Ganem F, Morinaga CV.   +6 more
europepmc   +1 more source

Knowledge, Attitude and Practice in Anxiety, Pain and Medical Emergency Management: A National Survey on 232 Italian Dental Students

European Journal of Dental Education, EarlyView.
ABSTRACT Background Anxiety, pain and medical emergencies are crucial concepts in the dental field. Dental students need training, but little is known of their competence on these topics. Aim The aim of this study was to assess the current state of Italian dental students' preparation for, attitudes to, and perceptions of medical emergency, anxiety and
Niccolò Giuseppe Armogida, Luigi Esposito, Gianrico Spagnuolo, Mariangela Cernera, Carlo Rengo, Luca Signorini, Antonino Fiorino   +6 more
wiley   +1 more source

Protocol of a multi-centre randomized controlled trial to compare pericapsular nerve group block, fascia-iliaca compartment block and femoral nerve block for pain management in patients with a hip fracture in the emergency department (CPFF-ED). [PDF]

PLoS One
Dolstra J, Haak SL, Boerma EC, Lameijer H, Avest ET.   +4 more
europepmc   +1 more source

Analgesic effects of alpha‐2‐adrenoreceptor agonists in equine medicine: systemic, spinal, and local applications

Equine Veterinary Education, EarlyView.
Summary Alpha‐2‐adrenoreceptor agonists provide analgesia when used as sole agents but can also be used in combination with other drugs for their additive and potentially synergistic effects. Further, because of their effects on blood flow, alpha‐2‐adrenoreceptor agonists act to extend and perhaps intensify the effects of drugs, such as local ...
J. Brandly, J. R. Page, J. A. E. Hubbell, W. W. Muir III, K. Hopster   +4 more
wiley   +1 more source