Results 11 to 20 of about 46,932 (244)

A diencephalic circuit in rats for opioid analgesia but not positive reinforcement

Nature Communications, 2022
Opioids are potent analgesics but also have addiction risk. Here a lateral preoptic area to lateral habenula connection is identified by which opioids relieve ongoing pain but do not produce reward in animals that do not have ongoing pain.
Maggie W. Waung, Kayla A. Maanum, Thomas J. Cirino, Joseph R. Driscoll, Chris O’Brien, Svetlana Bryant, Kasra A. Mansourian, Marisela Morales, David J. Barker, Elyssa B. Margolis   +9 more
doaj   +1 more source

Predictors of the use of analgesic drugs 1 year after joint replacement: a single-center analysis of 13,000 hip and knee replacements

Arthritis Research & Therapy, 2020
Background Pain persists in a moderate number of patients following hip or knee replacement surgery. Persistent pain may subsequently lead to the prolonged consumption of analgesics after surgery and expose patients to the adverse drug events of opioids ...
Tuomas Jaakko Rajamäki, Pia A. Puolakka, Aki Hietaharju, Teemu Moilanen, Esa Jämsen   +4 more
doaj   +1 more source

Management of pain treatment in the early postoperative period. Practice of using ketorolac. A clinical case

Медицина болю, 2020
The current strategy of rational perioperative analgesia involves reducing the use of opioid analgesics and preventing associated side effects. Today it is known that the use of opioid analgesics can further lead to the development of hyperalgesia ...
Dmytro Dmytriiev, A Andriiets, E Andriiets, V Bankivsky, S Yatsenko   +4 more
doaj   +1 more source

Contemporary management of pain in cirrhosis: Toward precision therapy for pain

Hepatology, EarlyView., 2022
Abstract Chronic pain is highly prevalent in patients with cirrhosis and is associated with poor health‐related quality of life and poor functional status. However, there is limited guidance on appropriate pain management in this population, and pharmacologic treatment can be harmful, leading to adverse outcomes, such as gastrointestinal bleeding ...
Alexis Holman, Neehar Parikh, Dan J. Clauw, David A. Williams, Elliot B. Tapper   +4 more
wiley   +1 more source

Effects of long-term opioid analgesics on cognitive performance and plasma cytokine concentrations in patients with chronic low back pain: a cross-sectional pilot study

PAIN Reports, 2018
. Introduction:. Cognitive performance and inflammation are altered in people with chronic low back pain (CLBP). Yet, the magnitude of these changes has been unclear because of the potential influence of opioid analgesics. Objectives:.
Georgia C. Richards, Lesley J. Lluka, Maree T. Smith, Catherine Haslam, Brendan Moore, James O'Callaghan, Jenny Strong   +6 more
doaj   +1 more source

Opioid peptide-derived analgesics [PDF]

The AAPS Journal, 2005
Two recent developments of opioid peptide-based analgesics are reviewed. The first part of the review discusses the dermorphin-derived, cationic-aromatic tetrapeptide H-Dmt-D-Arg-Phe-Lys-NH(2) ([Dmt(1)]DALDA, where Dmt indicates 2',6'-dimethyltyrosine), which showed subnanomolar mu receptor binding affinity, extraordinary mu receptor selectivity, and ...
openaire   +2 more sources

Healthcare professionals’ perceptions on the use of opioid analgesics for the treatment of cancer-related pain in Cyprus: A mixed-method study

SAGE Open Medicine, 2019
Objectives: Pain is considered the most common and debilitating symptom reported by patients affected by cancer, and opioids are at the front line for its effective management.
Andreas Charalambous, Marios Zorpas, Constantina Cloconi, Yolanda Kading   +3 more
doaj   +1 more source

Pain medication purchases before and after total hip and knee arthroplasty: a register study of 329,743 arthroplasties

Acta Orthopaedica, 2022
Background and purpose: Total hip (THA) and knee (TKA) arthroplasty are effective pain treatment in osteoarthritis; however, there are patients with long-term pain and in need of analgesics.
Ville Turppo, Reijo Sund, Jukka Huopio, Heikki Kröger, Joonas Sirola   +4 more
doaj   +1 more source

Predictors of shortages of opioid analgesics in the US: Are the characteristics of the drug company the missing puzzle piece?

PLoS ONE, 2021
BackgroundShortages of opioid analgesics are increasingly common, interfere with patient care and increase healthcare cost. This study characterized the incidence of shortages of opioid analgesics in the period 2015-2019 and evaluated potential ...
Rosa Rodriguez-Monguio, Mahim Naveed, Enrique Seoane-Vazquez   +2 more
doaj   +1 more source

Prescription analgesic medication use among osteoarthritis patients

Journal of Orthopaedic Surgery, 2023
Objective Pharmacotherapy is the most common strategies to reduce pain for osteoarthritis (OA) patients. To analyze the trend and pattern of prescription analgesic medication use in American OA patients.
Zhenzhen Huang, Xinxin Chen, Xihong Gan, Jiajia Chen   +3 more
doaj   +1 more source